ID H0V1C0_CAVPO Unreviewed; 4501 AA.
AC H0V1C0;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 84.
DE SubName: Full=Dynein axonemal heavy chain 11 {ECO:0000313|Ensembl:ENSCPOP00000003280.3};
GN Name=DNAH11 {ECO:0000313|Ensembl:ENSCPOP00000003280.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000003280.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000003280.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000003280.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR EMBL; AAKN02032451; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02032452; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02032453; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02032454; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02032455; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_013007889.1; XM_013152435.1.
DR STRING; 10141.ENSCPOP00000003280; -.
DR Ensembl; ENSCPOT00000003676.3; ENSCPOP00000003280.3; ENSCPOG00000003632.4.
DR GeneID; 100733692; -.
DR KEGG; cpoc:100733692; -.
DR CTD; 8701; -.
DR VEuPathDB; HostDB:ENSCPOG00000003632; -.
DR eggNOG; KOG3595; Eukaryota.
DR GeneTree; ENSGT00940000158880; -.
DR HOGENOM; CLU_000038_7_2_1; -.
DR InParanoid; H0V1C0; -.
DR OMA; ICEHMAY; -.
DR OrthoDB; 166463at2759; -.
DR TreeFam; TF316836; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000003632; Expressed in liver and 8 other cell types or tissues.
DR GO; GO:0097728; C:9+0 motile cilium; IEA:Ensembl.
DR GO; GO:0097729; C:9+2 motile cilium; IEA:Ensembl.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005576; C:extracellular region; IEA:GOC.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0120134; C:proximal portion of axoneme; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0060411; P:cardiac septum morphogenesis; IEA:Ensembl.
DR GO; GO:0035545; P:determination of left/right asymmetry in nervous system; IEA:Ensembl.
DR GO; GO:0060287; P:epithelial cilium movement involved in determination of left/right asymmetry; IEA:Ensembl.
DR GO; GO:0030317; P:flagellated sperm motility; IEA:Ensembl.
DR GO; GO:0007611; P:learning or memory; IEA:Ensembl.
DR GO; GO:0120229; P:protein localization to motile cilium; IEA:Ensembl.
DR GO; GO:0003356; P:regulation of cilium beat frequency; IEA:Ensembl.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703:SF12; DYNEIN AXONEMAL HEAVY CHAIN 11; 1.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT DOMAIN 1882..2018
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2487..2632
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2832..2943
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 807..834
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3305..3374
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3659..3686
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4501 AA; 518863 MW; B782B5825E86594B CRC64;
MAAREATWEA RGSRDVPTLR LTREAGLEED EEEDEEEAAA VRRAQNFARD ARVRFLCGRL
QQMLGIREET WSRYLESEDN RQVLGEFLER DSPACLVFSV TGAGQLAASR EIPRDAKYKL
VYVAKKITES SGTNFSQKML FEELSASSLG HVTAFLDEIL VPILSNKNNH KSWSYFTSQD
MECHTEIMKT KMHIFKGKMS RRTLLPIPTI AEYIDLDQNY SQIKLPSSER RLLHEIESAV
IRWSHQIQEI VERDSAQPLL NGLHLSPQTE LDFWMMRREN LSCIYDQLQA PVILKMVQIL
KSKQSSYFPT LKNIFLAVEN ALLEAQDVEL YLRPLRRHIQ CLQETEFPQT CALMAPLFHT
ICLIWSHSKF YNTPARIIVL LQEFCNLFID QAMDYLSPED LLKGEIEDSL EKVQVATNIL
KTFKNSFFNY KKKLASYFTR EKEPRPWDFQ SHLVFCRFDK FLDRLMKMED IFVTMLEFEK
LERLEFGGTK GAILNEQIHE MSEEFMDLCK IFRQSTYDPS DYDNMEFEND YVAFKSKILD
FDRRLGTILC EAFYNCHGLE AAFKLLTIFG NFLEKPVVME IFNPHCSTLV NMFNTELDVC
KQLYNEHIKQ IEHGHVVLNK NMPYISGNIK WAKEVLERLQ TFWSNFVSLH YLFLDNPDEA
TVYQKYVEMT TLLDQFEKQI YNEWKSNVDE ICEFNLNQPL VKFSARSGLL SVNFDSKLVA
VLREVKYLLM LKKPDIPESA LAIFKKRNAL LKYIGNLELL VQGYNKLKQT LLEVEYPLIK
DELEALDEQL KAPATWLTWQ DDCWEYVEKV QVAMAELEHR VEQAQSNVHR VQQTMRAWAE
CPLLSKRELR REAALTLEGK GDLFTKKHKL IQEDGLKIHD LVEENRKLFK ADSSLDAWKI
YVEFIDDIVV EGFFQAIMHD LDFFLENTEK QLKPAPFFQA QMILMPPEIV FKPPLEREAG
DGIYDLVEEM LCRSFRMSAQ MKRVAAHLEI ENYQNDMDTM LGLAEARQEI MNRVSDVINK
VLDFRNSLET YAYLWVDDRA EFMKHFLLYG HTTSSEEMDA HANEDIPEQP PTLEQFKEQI
DIYEALYIQM SKFDDFRVFN NWFKVDMKHF KVTLLNVIKK WSWMFQEHLL RFVIDSLNEL
QEFMKDTDAA LQRKLCEGDH DGLVDIMEHL LAVRSRQRAT DELFEPLKET ITLLESYGQK
MPEQVHAQLE ELPERWETTK KIAATVRHEV SPLQNAEVIL IRKKCILFDE KQAEFRERFR
SYAPLGFNAE NPYTALDKAH QELEALEEEM AQMQDSACLF EVALPEYKQM KQCRKEIRLL
KGLWDVIIYV RRSIDNWTKT QWRQINVEQM DVELRRFAKE ICSLDKAVRV WDAYTDLEGT
VKDMTTFLRA ISELQSPALR DRHWHQLMKA IGVTFSINEA TTLADLLALQ LHRVEDEVQS
IVDKAVKELG TEKVITEISQ TWATMEFSYE IHYRTSIPLL KSDEQLFETL EHNQVQLQTV
LQSKYVEYFI EQVLSWQNKL NIADSVIFTW MEVQRTWSHL ESIFICSEDI QIQLVEDARR
FDGVDAEFKE LMFKTAKTKN VLEATCRPHL YEKLKDLQYR LSLCEKALAE YLETKRVAFP
RFYFISSADL LDILSKGTQP KQVTHHLAKL FDSIADLQFE DNQDISAHRA IGMYSKEKEH
VSFPAECECI GHVETWLLQL EQTMQETVRQ SITEAITAYE EKPRELWIFD FPAQVALTSS
QIWWTTDVGI AFSRLEEGYE TALKDFHKKQ ISQLNTLIML LLGELPPGDR QKIMTICTID
VHARDVVGKL ISQKVVSPQA FAWLSQLRHQ WDDTQKHCFV NICDAQFQYF YEYLGNSPRL
VITPLTDRCY ITLTQSLHLT MSGAPAGPAG TGKTETTKDL GRALGMMVYV FNCSEQMDYK
SIGNIYKGLV QTGAWGCFDE FNRIAVEVLS VVAVQVKMIH DAIRNGKKRF VFLGEAITLK
PSVGIFITMN PGYAGRTELP ENLKALFRPC AMVAPDIELI CEIMLVAEGF VDARSLAQKF
IALYTLCKEL LSKQDHYDWG LRAIKSVLVV AGSLKRGDKN RPEDQVLMRA LRDFNMPKIV
TEDVPVFLGL VGDLFPALDV PRGRKQHLEQ MVRQSTLELR LQPEESFILK VVQLEELLAI
RHCVFVVGNA GTGKSKILRT LNRTYVHMKQ KPVWNDLNPK AVTTDELFGF IHHATREWKD
GLFSSILREQ ANLTHDGPKW IVLDGDIDPM WIESLNTVMD DNKVLTLASN ERVALTPSMR
LLFEIHHLRT ATPATVSRAG VLYVNPQDLG WNPYVASWID RRRHQSEKAN LTILFDKYIP
ACLDKLRTSF KTITPIPENS LVQTVCALLD CLLTPENVPS DSPKEVYEVY FVFACIWAFG
GTLLQDQLSD YQADFSRWWH KEMKVVKFPS QGTIFDYYLD HKTKKFLPWA DKIPQFTMDP
DAPLQTVLVH TSETIRLRYF IELLLEKRKP LMLVGNAGVG KTVLVGDILA SLSEDFIVSR
VPFNYYTTSA ALQRILEKPL EKKAGRNYGP GGNKKLVYFI DDINMPKVDL YGTVQPHTLI
RQHIDYGHWY DRQKATLKEI HNCQYVTCMN PMVGSFTVSP RLQRHFTVFA FNFPSLDALN
TIYGQIFSFH FQHQAFAPSL LRSGTSLIQA TIAFHHMMTQ NFLPTAIKFH YIFNLRDLSN
IFQGILFASP ECLKDPNDLI HLWLHESSRV YGDKLIDKRD CDLFQKKILE VAYKYFEGLN
SHVLLQQPLV YCHFAKGGED SSYMPVKDWE ALKVILTESL DNYNELHAAM HLVLFEDAMQ
HVCRISRILR APQGHALLIG VGGSGKQSLS RLAAHICNLE VFQVTLTECY GIQDLRVDLA
NLYIRTGAKN MPTAFLLTDA HVLDESFLVL INDLLVSGEI PDLFSEEDVD KIVSGVRNEV
RGLGMVNSKE NCWKFFLARV RLQLKIVLCF SPVGHTLRVR ARKFPAVVNC TAIDWFHAWP
QEALVSVSRR FIEETEGIEA RHKDSISCFM AHVHTSVNEM SARYYQNERR HNYTTPKSFL
EQISLFKNLL KKKQKEVAQK KEHLMNGIQK LKTTASQVGD LKARLASQEA ELQLKNHDAE
ALITKIGLQT EKVRREKAIA DAEEQKVTAI QTEVCQKQKE CEADLLKAEP ALVAATAALN
TLNRVNLTEL KAFPNPPNAV TNVTAAVMVL LAPRGRVPKD RSWKAARIFM GKVDDFLQAL
INYDKEHIPE NCLKVVNEQY LKDPEFSPNL IRTKSFAAAG LCAWVINIIK FYEVYCDVEP
KRQALAQANL DLTAATEKLV AIRKKLGELD QHLCRLTASL EKAIAEKVRC QEEVNQTNKT
IELANRLVRE LESEKVRWGQ SIQCFEAQEK TLCGDVLLTA AFVSYVGSFT KQYRQELLYL
KWIPFLQQKV SIPITGGLDV VAMLTDDATI ATWSNEGLPS DRMSTENATI LTHCERWPLM
IDPQQQGIKW IKNKYGTDLK VTHVGQKGFL NAIETALAFG NVILVENLEE TIDPVLDPLL
GRNTIKKGKY IRIGDRECEF NKNFRLILHT KLANPHYKPE LQAQTTLLNF TVTEDGLEAQ
LLAEVVSVER PDLEKLKLTL TKHQNDFKIE LKLLEDDLLL RLSAAEGSFL DDTDLVERLE
TTKSTAAEIE RKVTEAKENE RKINEARECY RPVAARASLL YFVINDLRNI NPIYQFSLKA
FNTLFHRAIE QADKVEDTQE RISVLTESLT HAIFLYTSRA LFEKDKLTFL SQMAFQILLR
KKEIDPIELD FLLRFTVERT YLSPVDFLTT QSWSAIKAVA LMEEFQGLDR DIEGSAKQWR
KWVESECPEK EKLPQEWKKK SLIQKLIILR AVRPDRMTYA LRNFVEEKLG AKYVERTRLD
LGKALEESSP ATPVFFILSP GVDALKDLEI LGKRLGFTID EGKFHNVSLG QGQEMVAEMA
LEKASRGGHW VILQNVHLVA KWLGTLEKLL EGFSQGSHED YRVFMSAECA PTPDEHIIPQ
GLLENSIKIT NEPPTGMLAN LHAALYNFDQ DTLEICSKEQ EFKSILFSLC YFHACVAGRL
RFGPQGWSRS YPFNSGDLTI CSNILYNYLE ANANVPWEDL RYLFGEIMYG GHITDVWDRR
LCRVYLEEFM NPSLIEDELM LAPGFAAPPY LDYSGYHQYI EETLPPESPA LYGLHPNAEI
EFLTVTSNTL FRTLLEMQPS TAHGSDELGQ STEDKVRNVL DDILERLPEE FNMAEIMQKT
SNRSPYVLVC FQECERMNIL IREIRVSLQQ LDLGLKGELV LSPDVEAQHS ALSYDRVPHT
WSKLAYPSTY SLAQWFNDLL LRCRELDTWT QDLALPAVVW LSGFFNPQSF LTAIMQTMAR
KNEWPLDRMC LTVDVTKKVK EDYSHAPREG AYLHGLQMEG ARWDIQCGTI VEARLKELTS
MMPVIFAKAI PMDRQETKHT YECPVYINKM RGPTYIWTFR LKTKEKTAKW VLAGVALLLE
A
//
