ID H0V3H3_CAVPO Unreviewed; 430 AA.
AC H0V3H3;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=Dynein regulatory complex protein 10 {ECO:0000256|ARBA:ARBA00021752};
DE AltName: Full=IQ domain-containing protein D {ECO:0000256|ARBA:ARBA00032180};
GN Name=IQCD {ECO:0000313|Ensembl:ENSCPOP00000004135.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000004135.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000004135.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000004135.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Component of the nexin-dynein regulatory complex (N-DRC), a
CC key regulator of ciliary/flagellar motility which maintains the
CC alignment and integrity of the distal axoneme and regulates microtubule
CC sliding in motile axonemes. {ECO:0000256|ARBA:ARBA00003029}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, flagellum axoneme
CC {ECO:0000256|ARBA:ARBA00004611}.
CC -!- SIMILARITY: Belongs to the DRC10 family.
CC {ECO:0000256|ARBA:ARBA00009071}.
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DR EMBL; AAKN02056159; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0V3H3; -.
DR STRING; 10141.ENSCPOP00000004135; -.
DR Ensembl; ENSCPOT00000004637.3; ENSCPOP00000004135.3; ENSCPOG00000004588.4.
DR VEuPathDB; HostDB:ENSCPOG00000004588; -.
DR eggNOG; ENOG502QQS9; Eukaryota.
DR GeneTree; ENSGT00730000111354; -.
DR HOGENOM; CLU_637710_0_0_1; -.
DR InParanoid; H0V3H3; -.
DR OMA; QFHNLVM; -.
DR TreeFam; TF326203; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000004588; Expressed in testis and 1 other cell type or tissue.
DR GO; GO:0036064; C:ciliary basal body; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.190; -; 1.
DR InterPro; IPR042815; DRC10.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR PANTHER; PTHR31598:SF1; DYNEIN REGULATORY COMPLEX PROTEIN 10; 1.
DR PANTHER; PTHR31598; IQ DOMAIN-CONTAINING PROTEIN D; 1.
DR Pfam; PF00612; IQ; 1.
DR SMART; SM00015; IQ; 1.
DR PROSITE; PS50096; IQ; 1.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT COILED 204..231
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 326..374
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 430 AA; 50028 MW; 8A6427F2431F1EC3 CRC64;
ASGPVCQAAD ISRIPLKTEL CPKPAEPLKP LVPSKSKLAT IEAKRIMSVL DEAIYKVELV
TLLCDMVGHP EALVEMREDL AGALREHGAL CQALQDSVGS LQEKARRLQE EEDAEEAWLY
DHRLSMELHK ASLPMLMQQV RDSTKNILRL LASDPQATKF LQMQAFRRST GAQRFMEGLV
ELRGFLFEKL LTSPMQAREK AQFLQDISRR NQRNQEAIDI LQKELASRQK NRDAEVEKEN
FVIQELKNHL HQVLKLSEHS LLRTRQEAER QQKADFRASQ ARLAKTQQEI LVLRSQYHNL
VSENHEAEQA LRKKKYKVET EVENWIQKYD MEMSEKQEEI EDLETVHLEE KLQLEELKQR
YEVLVEEFNQ IRAEREISSK KRLEAEREML RMVRAATLIQ AVWKGYLVRS MLRFKKRKKR
GKGQGKGKGK
//
