ID H0V4F5_CAVPO Unreviewed; 696 AA.
AC H0V4F5;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=Holliday junction recognition protein {ECO:0008006|Google:ProtNLM};
GN Name=Hjurp {ECO:0000313|Ensembl:ENSCPOP00000004495.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000004495.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000004495.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000004495.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAKN02019307; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02019308; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_013013229.1; XM_013157775.1.
DR AlphaFoldDB; H0V4F5; -.
DR STRING; 10141.ENSCPOP00000004495; -.
DR Ensembl; ENSCPOT00000005048.3; ENSCPOP00000004495.3; ENSCPOG00000004994.4.
DR GeneID; 100718607; -.
DR KEGG; cpoc:100718607; -.
DR CTD; 55355; -.
DR VEuPathDB; HostDB:ENSCPOG00000004994; -.
DR eggNOG; ENOG502SJZT; Eukaryota.
DR GeneTree; ENSGT00390000005575; -.
DR HOGENOM; CLU_408789_0_0_1; -.
DR InParanoid; H0V4F5; -.
DR OMA; YGQWASS; -.
DR OrthoDB; 4638446at2759; -.
DR TreeFam; TF336293; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000004994; Expressed in testis and 10 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR Gene3D; 6.10.250.2320; -; 1.
DR InterPro; IPR022102; HJURP_C.
DR InterPro; IPR021052; HJURP_central_dom.
DR PANTHER; PTHR15992; HOLLIDAY JUNCTION RECOGNITION PROTEIN; 1.
DR PANTHER; PTHR15992:SF5; HOLLIDAY JUNCTION RECOGNITION PROTEIN; 1.
DR Pfam; PF12347; HJURP_C; 2.
DR Pfam; PF12346; HJURP_mid; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT DOMAIN 258..372
FT /note="Holliday junction recognition protein HJURP central"
FT /evidence="ECO:0000259|Pfam:PF12346"
FT DOMAIN 394..446
FT /note="Holliday junction regulator protein family C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF12347"
FT DOMAIN 535..594
FT /note="Holliday junction regulator protein family C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF12347"
FT REGION 79..118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 159..202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 303..323
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 345..365
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 535..555
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 96..110
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 163..201
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 696 AA; 77741 MW; F378AF4D147FB2D0 CRC64;
MEVQALQGEC PKEDTLVLKL RETRRRFQRR MQQLIAKYEH PFEDDPLVHM STLTYKTPKG
LRFWGGRLIT ETNQGQIQDA LGNQGDEPLH PHSRVWGTDS GSSDTEVAAS DQEDPSACAL
APAVPQSPLK DDLRRKYLTQ VDILLLGVED FEGIEKGVRK DTTRTLGPST ASPAIPAPGS
SSDDSTESLG SPVQPASSST AGGPLYPCPA DLTVVPRSNS PWFLETSSYS CLSSQSFKAA
DVCNATISDL YAGMLHSMSR LLSMKPACVI STKTFTMRHW GSRRRRPHRS WAQMNRTFSI
GARHSRRHAK RRPYPEPQGE RQTLRDCKNF LHKARHKKGV KLEKPLLEEN KPQLPELDPS
RKELPVVPRK SSSLTYLGNS ARLDREKRLM TLKWLISPVK MVSQPRMLQG HAETRYSEIE
TRFNRLHREC CLSPRKHPRA AGCLDALDVY RSGCVSPGSP QALEAHRLRF PFSRAYPKSL
SETFEHLDKR WVKVSRCPPK DSLASCSQSH LPQNTCISAP TSNLFQGHNA GALRKAASPS
QAISAPGTDP LSRPKSSYAE IKARFDQLHQ RILQMSPQQA KVPSHVGMCG NKASMGVWCQ
TGDSFRKLNL DPGFQGLTRS PWGSVTVEAH VSAGTAMKDP PDPAKRRRLW EPMVCGLQTW
RTGHPIPAQL GRKSYASVCR PAQEKEEHNL QDKREK
//
