ID H0V4S3_CAVPO Unreviewed; 546 AA.
AC H0V4S3;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=Amine oxidase {ECO:0000256|RuleBase:RU362067};
DE EC=1.4.3.- {ECO:0000256|RuleBase:RU362067};
GN Name=IL4I1 {ECO:0000313|Ensembl:ENSCPOP00000004627.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000004627.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000004627.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000004627.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974,
CC ECO:0000256|RuleBase:RU362067};
CC -!- SIMILARITY: Belongs to the flavin monoamine oxidase family.
CC {ECO:0000256|RuleBase:RU362067}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAKN02046403; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_013003341.1; XM_013147887.1.
DR AlphaFoldDB; H0V4S3; -.
DR STRING; 10141.ENSCPOP00000004627; -.
DR Ensembl; ENSCPOT00000005198.3; ENSCPOP00000004627.3; ENSCPOG00000005143.4.
DR GeneID; 100722053; -.
DR CTD; 259307; -.
DR VEuPathDB; HostDB:ENSCPOG00000005143; -.
DR eggNOG; KOG0029; Eukaryota.
DR GeneTree; ENSGT00940000162082; -.
DR HOGENOM; CLU_004498_8_3_1; -.
DR InParanoid; H0V4S3; -.
DR OMA; GIAVGWH; -.
DR OrthoDB; 3597164at2759; -.
DR TreeFam; TF313314; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000005143; Expressed in testis and 13 other cell types or tissues.
DR GO; GO:0001669; C:acrosomal vesicle; IEA:Ensembl.
DR GO; GO:0005576; C:extracellular region; IEA:Ensembl.
DR GO; GO:0001772; C:immunological synapse; IEA:Ensembl.
DR GO; GO:0097225; C:sperm midpiece; IEA:Ensembl.
DR GO; GO:0001716; F:L-amino-acid oxidase activity; IEA:Ensembl.
DR GO; GO:0006559; P:L-phenylalanine catabolic process; IEA:Ensembl.
DR GO; GO:0002841; P:negative regulation of T cell mediated immune response to tumor cell; IEA:Ensembl.
DR GO; GO:0042130; P:negative regulation of T cell proliferation; IEA:Ensembl.
DR GO; GO:0045591; P:positive regulation of regulatory T cell differentiation; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0019440; P:tryptophan catabolic process to indole-3-acetate; IEA:Ensembl.
DR GO; GO:0006572; P:tyrosine catabolic process; IEA:Ensembl.
DR Gene3D; 3.90.660.10; -; 2.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR Gene3D; 1.10.405.10; Guanine Nucleotide Dissociation Inhibitor, domain 1; 1.
DR InterPro; IPR002937; Amino_oxidase.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR001613; Flavin_amine_oxidase.
DR PANTHER; PTHR10742; FLAVIN MONOAMINE OXIDASE; 1.
DR PANTHER; PTHR10742:SF21; L-AMINO-ACID OXIDASE; 1.
DR Pfam; PF01593; Amino_oxidase; 1.
DR PRINTS; PR00757; AMINEOXDASEF.
DR SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827, ECO:0000256|RuleBase:RU362067};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630,
KW ECO:0000256|RuleBase:RU362067};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU362067};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..37
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 38..546
FT /note="Amine oxidase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5011460116"
FT DOMAIN 77..516
FT /note="Amine oxidase"
FT /evidence="ECO:0000259|Pfam:PF01593"
SQ SEQUENCE 546 AA; 60403 MW; CE8D4E5BB717C915 CRC64;
MGAERAPQSQ PCTLCLLVLV SILCSLVASL AWNAALGQDP FKKCMHDQDY EQLLKVVTLG
LNRTLQPQKV IVVGAGVAGL VAAKVLNDAG HKVTILEADN RIGGRILTFR DPKTGWSGEL
GAMRMPSSHR ILHALCKSLG LNLTKFTQYD ENTWTEVNGV KLRNHVVKKT PEKLGYKLRP
KERGHSPEDI YQMALNKALK DVKALGCKKA MRKFERHTLL EYLLGEGNLS RPAVQLLGDV
MAKDGFFYLS FQEALRAHSC LSDRLRYSRI VGGWDLLPRA LLSSLSGPLV LNAQVVALTQ
GTKDVRVHIA SSHRSQSLKS LTADMVLLTA SGPALQRMTF SPPLTRKRQE ALRSLHYVPA
TKVFLSFRRP FWHDEHIEGG HSNTDRLART IFYPPPGEGA LLLASYTWSD AATPFAGLST
EDALRLALDD VAALHGQFVY RLWDKTGVIK RWAEDPYSQG GFVVQPPVLR ETEDSEKPYN
WAAPYGRIFF AGEHTAYPHG WVETAVKSAL RAALQINSDQ GQATLEAALA ELRAAAPAPA
RWEILH
//
