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Database: UniProt
Entry: H0V587_CAVPO
LinkDB: H0V587_CAVPO
Original site: H0V587_CAVPO 
ID   H0V587_CAVPO            Unreviewed;       186 AA.
AC   H0V587;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 2.
DT   24-JAN-2024, entry version 75.
DE   RecName: Full=ADP-ribosylation factor-like protein 6 {ECO:0000256|ARBA:ARBA00019766};
GN   Name=ARL6 {ECO:0000313|Ensembl:ENSCPOP00000004806.3};
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC   Cavia.
OX   NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000004806.3, ECO:0000313|Proteomes:UP000005447};
RN   [1] {ECO:0000313|Proteomes:UP000005447}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA   Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA   Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA   Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA   Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA   Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA   Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA   Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA   Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA   Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA   Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA   Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA   Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA   Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA   Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSCPOP00000004806.3}
RP   IDENTIFICATION.
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000004806.3};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane
CC       {ECO:0000256|ARBA:ARBA00004522}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004522}; Cytoplasmic side
CC       {ECO:0000256|ARBA:ARBA00004522}.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Arf family.
CC       {ECO:0000256|RuleBase:RU003925}.
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DR   EMBL; AAKN02051598; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02051599; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_003463354.2; XM_003463306.3.
DR   AlphaFoldDB; H0V587; -.
DR   STRING; 10141.ENSCPOP00000004806; -.
DR   Ensembl; ENSCPOT00000005401.3; ENSCPOP00000004806.3; ENSCPOG00000005344.4.
DR   GeneID; 100721392; -.
DR   KEGG; cpoc:100721392; -.
DR   CTD; 84100; -.
DR   VEuPathDB; HostDB:ENSCPOG00000005344; -.
DR   eggNOG; KOG0070; Eukaryota.
DR   GeneTree; ENSGT00940000156459; -.
DR   HOGENOM; CLU_040729_9_1_1; -.
DR   InParanoid; H0V587; -.
DR   OMA; WQIVPSN; -.
DR   OrthoDB; 5349301at2759; -.
DR   TreeFam; TF105466; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   Bgee; ENSCPOG00000005344; Expressed in hypothalamus and 13 other cell types or tissues.
DR   GO; GO:0060170; C:ciliary membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015630; C:microtubule cytoskeleton; IEA:Ensembl.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0060271; P:cilium assembly; IEA:Ensembl.
DR   GO; GO:0061512; P:protein localization to cilium; IEA:Ensembl.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:Ensembl.
DR   CDD; cd04157; Arl6; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR041839; Arl6.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR024156; Small_GTPase_ARF.
DR   InterPro; IPR006689; Small_GTPase_ARF/SAR.
DR   NCBIfam; TIGR00231; small_GTP; 1.
DR   PANTHER; PTHR11711; ADP RIBOSYLATION FACTOR-RELATED; 1.
DR   PANTHER; PTHR11711:SF21; ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 6; 1.
DR   Pfam; PF00025; Arf; 1.
DR   PRINTS; PR00328; SAR1GTPBP.
DR   SMART; SM00177; ARF; 1.
DR   SMART; SM00178; SAR; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51417; ARF; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|RuleBase:RU003925};
KW   Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU003925};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005447}.
SQ   SEQUENCE   186 AA;  20949 MW;  FD40430877ABF39A CRC64;
     MGLLDRLSGF LGLRKKEVHV LCLGLDNSGK TTIINKLKPS NAQSQDIVPT IGFSIEKFKS
     SSLSFTVFDM SGQGRYRNLW EHYYKEGQAI IFVIDSSDTL RMVVAKEELD TLLNHPDIKH
     RRIPILFFAN KMDLKDAVTS VKVSQLLCLE NIKDKPWHIC ASDAIKGEGL QEGVDWLQDQ
     IQGAKT
//
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