ID H0V5C1_CAVPO Unreviewed; 356 AA.
AC H0V5C1;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=G protein subunit alpha 14 {ECO:0000313|Ensembl:ENSCPOP00000004849.2};
GN Name=GNA14 {ECO:0000313|Ensembl:ENSCPOP00000004849.2};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000004849.2, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000004849.2}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000004849.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the G-alpha family. G(q) subfamily.
CC {ECO:0000256|ARBA:ARBA00007976}.
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DR EMBL; AAKN02026242; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02026243; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02026244; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02026245; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003472275.1; XM_003472227.3.
DR AlphaFoldDB; H0V5C1; -.
DR STRING; 10141.ENSCPOP00000004849; -.
DR Ensembl; ENSCPOT00000005445.3; ENSCPOP00000004849.2; ENSCPOG00000005387.4.
DR GeneID; 100731029; -.
DR KEGG; cpoc:100731029; -.
DR CTD; 9630; -.
DR VEuPathDB; HostDB:ENSCPOG00000005387; -.
DR eggNOG; KOG0085; Eukaryota.
DR GeneTree; ENSGT00940000158510; -.
DR HOGENOM; CLU_014184_6_0_1; -.
DR InParanoid; H0V5C1; -.
DR OMA; CCVSAED; -.
DR OrthoDB; 2897309at2759; -.
DR TreeFam; TF300673; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000005387; Expressed in pituitary gland and 11 other cell types or tissues.
DR GO; GO:0001664; F:G protein-coupled receptor binding; IEA:InterPro.
DR GO; GO:0031683; F:G-protein beta/gamma-subunit complex binding; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR CDD; cd00066; G-alpha; 1.
DR Gene3D; 1.10.400.10; GI Alpha 1, domain 2-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR000654; Gprotein_alpha_Q.
DR InterPro; IPR001019; Gprotein_alpha_su.
DR InterPro; IPR011025; GproteinA_insert.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10218; GTP-BINDING PROTEIN ALPHA SUBUNIT; 1.
DR PANTHER; PTHR10218:SF213; GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-14; 1.
DR Pfam; PF00503; G-alpha; 1.
DR PRINTS; PR00318; GPROTEINA.
DR PRINTS; PR00442; GPROTEINAQ.
DR SMART; SM00275; G_alpha; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF47895; Transducin (alpha subunit), insertion domain; 1.
DR PROSITE; PS51882; G_ALPHA; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Transducer {ECO:0000256|ARBA:ARBA00023224}.
SQ SEQUENCE 356 AA; 41742 MW; 723E28B8335B480A CRC64;
MAGRCCCLSA EEKEAQRISA EIERQLRRDK KDARRELKLL LLGTGESGKS TFIKQMRIIH
GSGYSDEDRK GFTRLVYQNI FTAMQAMIRA MDSLRIQYVC EQNKENAQII RKVDVDKVSM
LSRDQVEAIK QLWQDPGIQE CYDRRREYQL SDSAKYYLTD IDRIAMPSFV PTQQDVLRVR
VPTTGIIEYP FDLENIIFRM VDVGGQRSER RKWIHCFESV TSIIFLVALS EYDQVLAECD
NENRMEESKA LFKTIITYPW FLNSSVILFL NKKDLLEEKI MYSHLISYFP EYTGPKQDVK
AARDFILKLY QDQNPDKEKV IYSHFTCATD TENIRFVFTA VKDTILQLNL REFNLV
//
