GenomeNet

Database: UniProt
Entry: H0V5H5_CAVPO
LinkDB: H0V5H5_CAVPO
Original site: H0V5H5_CAVPO 
ID   H0V5H5_CAVPO            Unreviewed;       858 AA.
AC   H0V5H5;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   25-OCT-2017, entry version 45.
DE   SubName: Full=Two pore segment channel 1 {ECO:0000313|Ensembl:ENSCPOP00000004906};
GN   Name=TPCN1 {ECO:0000313|Ensembl:ENSCPOP00000004906};
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricomorpha; Caviidae; Cavia.
OX   NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000004906};
RN   [1] {ECO:0000313|Ensembl:ENSCPOP00000004906}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000004906};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSCPOP00000004906}
RP   IDENTIFICATION.
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000004906};
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCPOP00000004906}.
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DR   EMBL; AAKN02056159; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSCPOT00000005508; ENSCPOP00000004906; ENSCPOG00000005450.
DR   eggNOG; ENOG410KCTW; Eukaryota.
DR   eggNOG; ENOG410XZT8; LUCA.
DR   GeneTree; ENSGT00530000063660; -.
DR   InParanoid; H0V5H5; -.
DR   OMA; WLGFHTF; -.
DR   OrthoDB; EOG091G038K; -.
DR   TreeFam; TF328550; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   Bgee; ENSCPOG00000005450; -.
DR   GO; GO:0010008; C:endosome membrane; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0072345; F:NAADP-sensitive calcium-release channel activity; IEA:Ensembl.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   GO; GO:0010508; P:positive regulation of autophagy; IEA:Ensembl.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028801; TPC1.
DR   PANTHER; PTHR10037:SF231; PTHR10037:SF231; 1.
DR   Pfam; PF00520; Ion_trans; 2.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005447};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    149    171       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    177    195       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    216    234       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    277    296       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    303    322       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    342    365       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    487    507       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    519    537       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    609    628       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    708    733       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      148    372       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      483    732       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   858 AA;  98586 MW;  7955E670BDF43481 CRC64;
     DASNGGVSEK HRGACGFDKQ LEPETVDSPG HHLLRHAGER SMAVNLDDDV PLILTMEEGG
     GAPAAPCNSL GPEELPSKNG GSHAIHDSQA PSLVFGGESS PSGPAGQDWE MNYQEAAIYL
     QEGENNDKFF THPKDAKALA AYLFAHNHVF YLMELLTALL LLLLTLCEAP AVPALRLGIY
     VHATLELFAL MVVVFELCMK LRWLGLHTFI RHKRTMVKTF VLVVQFVEAI VVLVRQTSHV
     RVTRALRCIF LVDCRYCGGV RRNLRQIFQS LPPFMDILLL LLFFMIIFAI LGFYLFSSNP
     SDPYFSTLEN SIVSVFVLLT TANFPDVMMP SYSRNPWSCV FFIVYLSIEL YFIMNLLLAV
     VFDTFNDIEK RKFKSLLLHK RTAIQHAFRL LTSQRKPMGI SYRQFEGLMR FYKPRMSARE
     RFLTFKALNQ SNKPLLSLED FCDIYEIATL KWKTKRNREH WFDELPRTAF LIFKGINMLV
     KSKAFQYFMY LVVAVNGVWI LVETFMLRGG NFISKPVPWS YLIFLTIYGV ELFLKVAGLG
     PVQYLSSRWN LFDFSVTVFA FLGLLALALN MEPFYFIVVL RPLQLLRLFK LKKRYSNVLD
     TMFELLPRMA SLGLTLLIFY YSFAIVGMEF FCGRLYPNCC NTSTVADAYR WLNHTVGDKT
     VVEEGYYYLN NFDNILNSFV TLFELTVVNN WYIIMEGVTS QTSHWSRLYF MTFYIVTMVV
     MTIIVAFILE AFVFRMNYSR KSQDSEVDGG ITVEKEISKE ELVAVLELYR GARGASSDVT
     RLLETLSQME KYQQNSLVFL GRRSRTKSDL SLKMYQEEIQ EWYAEHAREQ EAQRQLHGGT
     DPATQQAPYS RQRSQTVT
//
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