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Database: UniProt
Entry: H0V5L1_CAVPO
LinkDB: H0V5L1_CAVPO
Original site: H0V5L1_CAVPO 
ID   H0V5L1_CAVPO            Unreviewed;       502 AA.
AC   H0V5L1;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   22-NOV-2017, entry version 49.
DE   SubName: Full=Potassium voltage-gated channel modifier subfamily V member 1 {ECO:0000313|Ensembl:ENSCPOP00000004945};
GN   Name=KCNV1 {ECO:0000313|Ensembl:ENSCPOP00000004945};
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricomorpha; Caviidae; Cavia.
OX   NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000004945};
RN   [1] {ECO:0000313|Ensembl:ENSCPOP00000004945}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000004945};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSCPOP00000004945}
RP   IDENTIFICATION.
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000004945};
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the potassium channel family.
CC       {ECO:0000256|SAAS:SAAS00692852}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCPOP00000004945}.
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DR   EMBL; AAKN02000293; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_003479902.1; XM_003479854.3.
DR   STRING; 10141.ENSCPOP00000004945; -.
DR   Ensembl; ENSCPOT00000005550; ENSCPOP00000004945; ENSCPOG00000005491.
DR   GeneID; 100726358; -.
DR   CTD; 27012; -.
DR   eggNOG; KOG3713; Eukaryota.
DR   eggNOG; COG1226; LUCA.
DR   GeneTree; ENSGT00760000118981; -.
DR   InParanoid; H0V5L1; -.
DR   OMA; TIAQCYE; -.
DR   OrthoDB; EOG091G0FP3; -.
DR   TreeFam; TF313103; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   Bgee; ENSCPOG00000005491; -.
DR   GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:InterPro.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR   GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR003968; K_chnl_volt-dep_Kv.
DR   InterPro; IPR003970; K_chnl_volt-dep_Kv8.1.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   InterPro; IPR003131; T1-type_BTB.
DR   InterPro; IPR028325; VG_K_chnl.
DR   PANTHER; PTHR11537; PTHR11537; 1.
DR   PANTHER; PTHR11537:SF38; PTHR11537:SF38; 1.
DR   Pfam; PF02214; BTB_2; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   PRINTS; PR00169; KCHANNEL.
DR   PRINTS; PR01493; KV8CHANNEL.
DR   PRINTS; PR01491; KVCHANNEL.
DR   SMART; SM00225; BTB; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005447};
KW   Ion channel {ECO:0000256|SAAS:SAAS00417203};
KW   Ion transport {ECO:0000256|SAAS:SAAS00417186};
KW   Membrane {ECO:0000256|SAAS:SAAS00788393, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|SAAS:SAAS00417282};
KW   Potassium channel {ECO:0000256|SAAS:SAAS00417246};
KW   Potassium transport {ECO:0000256|SAAS:SAAS00417240};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00793138,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00789957,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00417268};
KW   Voltage-gated channel {ECO:0000256|SAAS:SAAS00091688}.
FT   TRANSMEM    213    234       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    246    264       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    348    369       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    409    429       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       41    159       BTB. {ECO:0000259|SMART:SM00225}.
SQ   SEQUENCE   502 AA;  56396 MW;  FE44F143A7AADBE1 CRC64;
     MELPPRGRGP PGSPLSSGSL TSLESSVFCS EGEGEPLALG DCFTVNVGGS RFVLSQQALS
     CFPHTRLGKL AVVVASYRRL GALAAAPSPL ELCDDANPVD NEYFFDRSSQ AFRYVLHYYR
     TGRLHVMEQL CALSFLQEIQ YWGIDELSID SCCRDRYFRR KELSETLDFK KDTDDQESQH
     ESEQDFSQGP CPTVRQKLWN ILEKPGSSTA ARIFGVISII FVAVSIVNMA LMSAELSWLN
     LQLLEVLEYV CISWFTGEFV LRFLCVRDRC RFLRKVPNII DLLAILPFYI TLLVESLSGS
     QTTQELENVG RIVQVLRLLR ALRMLKLGRH STGLRSLGMT ITQCYEEVGL LLLFLSVGIS
     IFSTVEYFAE QSIPDTTFTS VPCAWWWATT SMTTVGYGDI RPDTTTGKIV AFMCILSGIL
     VLALPIAIIN DRFSACYFTL KLKEAAARQR EALKKLTKNI ATDSYISVNL RDVYARSIME
     MLRLKGRERA STRSSGGDDF WF
//
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