ID H0V6G6_CAVPO Unreviewed; 1465 AA.
AC H0V6G6;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Neogenin 1 {ECO:0000313|Ensembl:ENSCPOP00000005285.3};
GN Name=NEO1 {ECO:0000313|Ensembl:ENSCPOP00000005285.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000005285.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000005285.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000005285.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. DCC family.
CC {ECO:0000256|ARBA:ARBA00009588}.
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DR EMBL; AAKN02054485; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02054486; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02054487; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02054488; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02054489; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02054490; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02054491; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005000127.1; XM_005000070.2.
DR STRING; 10141.ENSCPOP00000005285; -.
DR Ensembl; ENSCPOT00000005920.3; ENSCPOP00000005285.3; ENSCPOG00000005857.4.
DR GeneID; 100719461; -.
DR CTD; 4756; -.
DR VEuPathDB; HostDB:ENSCPOG00000005857; -.
DR eggNOG; KOG4221; Eukaryota.
DR GeneTree; ENSGT00940000156684; -.
DR HOGENOM; CLU_004256_0_0_1; -.
DR InParanoid; H0V6G6; -.
DR OMA; TSMSQPT; -.
DR OrthoDB; 5398621at2759; -.
DR TreeFam; TF321506; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000005857; Expressed in uterine cervix and 12 other cell types or tissues.
DR GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0030426; C:growth cone; IEA:Ensembl.
DR GO; GO:0097708; C:intracellular vesicle; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0098797; C:plasma membrane protein complex; IEA:Ensembl.
DR GO; GO:0070700; F:BMP receptor binding; IEA:Ensembl.
DR GO; GO:0045296; F:cadherin binding; IEA:Ensembl.
DR GO; GO:0039706; F:co-receptor binding; IEA:Ensembl.
DR GO; GO:0038023; F:signaling receptor activity; IEA:Ensembl.
DR GO; GO:0006879; P:intracellular iron ion homeostasis; IEA:Ensembl.
DR GO; GO:0060586; P:multicellular organismal-level iron ion homeostasis; IEA:Ensembl.
DR GO; GO:0007520; P:myoblast fusion; IEA:Ensembl.
DR GO; GO:0048681; P:negative regulation of axon regeneration; IEA:Ensembl.
DR GO; GO:0050709; P:negative regulation of protein secretion; IEA:Ensembl.
DR GO; GO:0030513; P:positive regulation of BMP signaling pathway; IEA:Ensembl.
DR GO; GO:0009306; P:protein secretion; IEA:Ensembl.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:Ensembl.
DR CDD; cd00063; FN3; 6.
DR CDD; cd00096; Ig; 1.
DR CDD; cd05722; IgI_1_Neogenin_like; 1.
DR CDD; cd05723; IgI_4_Neogenin_like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 10.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR010560; Neogenin_C.
DR PANTHER; PTHR44170:SF14; NEOGENIN; 1.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR Pfam; PF00041; fn3; 6.
DR Pfam; PF07679; I-set; 2.
DR Pfam; PF13895; Ig_2; 1.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF06583; Neogenin_C; 1.
DR PRINTS; PR00014; FNTYPEIII.
DR SMART; SM00060; FN3; 6.
DR SMART; SM00409; IG; 4.
DR SMART; SM00408; IGc2; 4.
DR SUPFAM; SSF49265; Fibronectin type III; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 4.
DR PROSITE; PS50853; FN3; 6.
DR PROSITE; PS50835; IG_LIKE; 4.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..34
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 35..1465
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5011573813"
FT TRANSMEM 1108..1132
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 53..148
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 153..239
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 242..337
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 342..427
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 462..556
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 562..652
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 657..752
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 762..855
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 861..957
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 962..1059
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 1046..1101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1142..1164
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1178..1210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1239..1280
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1293..1369
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1191..1210
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1293..1355
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1465 AA; 160357 MW; 41D863FDEA7472C2 CRC64;
MAAERGARRR LSASCFWLSC LLLLLARLAP GAGAARSGAP LPSAGVGVRT FTPFYFLVEP
VDTLSIRGSS VILNCSAYSE PSPKIEWKKD GTFLNLVSDD RRQLLPDGSL FISNVVHSKH
NKPDEGYYQC VATVDSLGTI VSRTAKLTVA GLPRFTSQPE PSSVYAGNSA VLNCEVNADL
VPFVRWEQNR QPLLLDDRII RLPSGTLVIS NVTEGDGGLY RCLVESGGPP KYSDEAELKV
LPDLEETANL VFLKQPSSLV RVIGQSAVLP CVASGFPAPA IRWMKNEELL NMESSERLVL
LAGGSLEIRD IIEDDAGTYF CIADNGNETI EAQAELMVQA QPEFLKQPAN IYAQESMDII
FECEVTGKPT PTVKWVKNGD MVIPSDYFKI VKEHNLQVLG LVKSDEGFYQ CIAENDVGNA
QAGAQLIILE HDVAIPTLPP TSLTSATTDH LAPATAGPLP SAPRDVVASL VSTRFIKLTW
RTPASDPHGD NLTYSVFYTK EGIARERVEN TSHPGEMQVT IQNLMPATVY IFRVVAQNKH
GSGESSAVLR VETQPEVQLP GPAPNIRAYP TSPTSVTVTW ETPVSGNGEI QNYKLYYMEK
GTDIEQDVDV SSHSYTINGL KKYTEYSFRV VAYNKHGPGV STQDVAVRTL SDVPSAAPQN
LSLEVRNSKS IMIHWQPPSL STQNGLITGY KIRYRKASRK SDVTEILVTG AQLSQLIEGL
DRGTEYNFRV AALTVNGTGP ATDWLSAETF ESDLDETRVP EVPSSLHVRP LVTSIVVSWT
PPENQNIVVR GYAIGYGIGS PHAQTIKVDY KQRYYTIENL DPSSHYVITL KAFNNVGEGI
PLYESAVTRP HTVPDPTPMM PPVGVQASIL SHDTIRITWA DNSLPKHQKI TDSRYYTVRW
KTNIPANTKY KNANATTLSY LVTGLKPNTL YEFSVMVTKG RRSSTWSMTA HGTTFELVPT
SPPKDVTVVS KEGKPRTIIV NWQPPSEANG KITGYIIYYS TDVNAEIHDW VIEPVVGNRL
THQIQELTLD TPYYFKIQAR NSKGMGPMSE AVQFRTPKAD SSDKMPNDQA SGSSGKGSRI
PDLGHDYKPP MSGSNSPHGS PSPLDSNMLL VIIVSVGVIT IVVVVIIAVF CTRRTTSHQK
KKRAACKSVN GSHKYKGNSK DVKPPDLWIH HERLELKPID KSPDPNPIMT DTPIPRNSQD
ITPVDNSMDS NIHQRRNSYR GHESEDSMST LAGRRGMRPK MMMPFDSQPP QPVISAHPIH
SLDNPHHHFH SSSLASPARS HLYHPGSPWP IGTSMSLSDR ANSTESVRNT PSTDTMPASS
SQTCCTDHQD PEGATSSSYL ASSQEEDSGQ SLPTAHVRPS HPLKSFAVPA VPPPGLPTYD
PALPSTPLLS QQALNHHIHS VKTASIGTLG RSRPPMPVVV PSAPEVQETT RMLEDSESSY
EPDELTKEMA HLEGLMKDLN AITTA
//
