ID H0V7R5_CAVPO Unreviewed; 1443 AA.
AC H0V7R5;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Pleckstrin homology like domain family B member 1 {ECO:0000313|Ensembl:ENSCPOP00000005788.3};
GN Name=PHLDB1 {ECO:0000313|Ensembl:ENSCPOP00000005788.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000005788.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000005788.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000005788.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAKN02024813; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSCPOT00000006489.3; ENSCPOP00000005788.3; ENSCPOG00000006424.4.
DR VEuPathDB; HostDB:ENSCPOG00000006424; -.
DR GeneTree; ENSGT00940000155231; -.
DR HOGENOM; CLU_003180_0_0_1; -.
DR InParanoid; H0V7R5; -.
DR OMA; DKKSPFQ; -.
DR TreeFam; TF329165; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000006424; Expressed in pituitary gland and 13 other cell types or tissues.
DR GO; GO:0045180; C:basal cortex; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0045171; C:intercellular bridge; IEA:Ensembl.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:1904261; P:positive regulation of basement membrane assembly involved in embryonic body morphogenesis; IEA:Ensembl.
DR GO; GO:0010717; P:regulation of epithelial to mesenchymal transition; IEA:Ensembl.
DR GO; GO:0010470; P:regulation of gastrulation; IEA:Ensembl.
DR GO; GO:0070507; P:regulation of microtubule cytoskeleton organization; IEA:Ensembl.
DR CDD; cd22713; FHA_PHLB1; 1.
DR CDD; cd14673; PH_PHLDB1_2; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR037810; PHLDB1/2/3_PH.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR PANTHER; PTHR12156:SF23; PLECKSTRIN HOMOLOGY-LIKE DOMAIN FAMILY B MEMBER 1; 1.
DR PANTHER; PTHR12156; PLECKSTRIN HOMOLOGY-LIKE DOMAIN, FAMILY B, MEMBER 3; 1.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT DOMAIN 1322..1436
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 149..184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 212..335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 370..568
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 655..710
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1029..1078
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1168..1197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 867..897
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1100..1127
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1203..1273
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 161..184
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 220..275
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 293..308
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 417..442
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 540..562
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 681..710
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1039..1078
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1168..1195
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1443 AA; 158321 MW; 87344D24F3B2B7B2 CRC64;
MDALNRSRVG PGCKTQAVVQ KGPLDLIDTG KGLKVQTDKP HLVSLGSGRL STAITLLPLE
EGRTVIGSAA KDISLQGPGL APEHCYIENL RGTLTLYPCG NACTIDGLLV RQPTRLTQGC
MLCLGQSTFL RFNHPAEAKW MKSMIPAGSR AAGPPYSPGS AESESLVNGN HTPQPATRGP
SACASHSSLV SSIEKDLQEI MDSLVLEEPV AAGKKPAATS PLSPMTNGGR YLLSPPTSPG
AMSVGSSYEN TSPAFSPLSS PASSGSCASH SPSGQEPGPS VPPLVPARSS SYHLALQPPQ
SRPSGGHSSD SPRLGRKGGH ERPPSPGLRG LLTDSPAATV LAEARRATES PRLGGQLPVV
AISLSEYPAS GVRSQPTSIP GSPKFQPPVP APRNKIGTLQ DRPPSPFHEP PGTERVLTTS
PMRQMVGRTF SDGSSTRTLQ PPESPRLGRR GLDSMRELPP LSPSLSRRAL SPLPARTTPD
PKLTREVAES PRPRRWAAHG TSPEDFSLTL GARGRRTRSP SPTLGESLAP RKGSFSGRLS
PAYSLGSLTG ASPRQSPRAQ RKLSSGDLRV PVVRDRKNSI TEISDNEDDL LEYHRRQRQE
RLREQEMERL ERQRLETILN LCAEYSRADG GPEAGELPSI GEATAALALA GRRPSRGLAG
PIVSSGRGGE ELGGATQRLW ESVERSDEEN LKEECSSTES TQQEHEDAPS TKLQGEILAL
EEERAQVLGH VEQLKVHVKE LEQQLQEAAR EAEMERALLQ GEREAERALL QKEQKAVEQL
QEKLMALETG IQKERDKEAE ALETETKLFE DLEFQQLERE SRAEEERELA GQGLLRSKAE
LLRSVAKRKE RLAILDSQAG QIRAQAVQES ERLAREKNAS LQLLQKEKEK LAMLERRYHA
LTGGRPFPKT TSTLKEYVTL EQLKVMWGTS PMPPAPAPGR PPWASASRDL VPTTCLPPVP
PSSSSFASIT PSPKMEKLLL PAVDLEQWYQ ELMAGLGTVP AAASPRSSPP PLPAKASRQL
QVYHSKVDGE AASPLPRTRS GPLPSSSGSS SSSSQLSVAT LGRSPSPKSA LLAQNGTGSL
PRNLAATLQD IETKRQLALQ QKGQQVIEEQ RRRLAELKQK AAAEAQCQWD ALHGAAPFPA
LVHHSILHHL PAGRDRGEES EHAYDTLSLE SSDSMETSIS TGGNSACSPD NMSSASGLDM
GKIEEMEKML REAHAEKSRL MESRVRLTWR RQRQREREME LRRQALEEER RRREQVERRL
QSEGARRQQL VEKEVKMREK QFSQARPLTR YLPIRKEDFD LKTHIESSGH GVDTCLHVVL
SSKVCRGYLV KMGGKIKSWK KRWFVFDRLK RTLSYYVDKH ETKLKGVIYF QAIEEVYYDH
LRSAAKKRFF RFTLVTESPN PALTFCVKTH DRLYYMVAPS AEAMRIWMDV IVTGAEGYTQ
FMN
//
