ID H0V9I3_CAVPO Unreviewed; 261 AA.
AC H0V9I3;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Calneuron 1 {ECO:0000313|Ensembl:ENSCPOP00000006475.2};
GN Name=CALN1 {ECO:0000313|Ensembl:ENSCPOP00000006475.2};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000006475.2, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000006475.2}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000006475.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Interacts with PI4KB. This binding competes with FREQ/NCS1
CC binding in a calcium-dependent manner. {ECO:0000256|ARBA:ARBA00038636}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004521};
CC Single-pass type IV membrane protein {ECO:0000256|ARBA:ARBA00004521}.
CC Cytoplasm, perinuclear region {ECO:0000256|ARBA:ARBA00004556}. Golgi
CC apparatus, trans-Golgi network membrane
CC {ECO:0000256|ARBA:ARBA00037801}; Single-pass type IV membrane protein
CC {ECO:0000256|ARBA:ARBA00037801}.
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DR EMBL; AAKN02045373; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02045374; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02045375; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02045376; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02045377; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02045378; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02045379; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0V9I3; -.
DR STRING; 10141.ENSCPOP00000006475; -.
DR Ensembl; ENSCPOT00000007252.3; ENSCPOP00000006475.2; ENSCPOG00000039564.1.
DR VEuPathDB; HostDB:ENSCPOG00000039564; -.
DR eggNOG; KOG0027; Eukaryota.
DR GeneTree; ENSGT00940000159212; -.
DR HOGENOM; CLU_106115_0_0_1; -.
DR InParanoid; H0V9I3; -.
DR OMA; EVHSQKQ; -.
DR TreeFam; TF331025; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000039564; Expressed in cerebellum and 7 other cell types or tissues.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032588; C:trans-Golgi network membrane; IEA:Ensembl.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00051; EFh; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR001751; S100/CaBP7/8-like_CS.
DR PANTHER; PTHR46311:SF3; CALCIUM-BINDING PROTEIN 8; 1.
DR PANTHER; PTHR46311; CALCIUM-BINDING PROTEIN 8-RELATED; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF47473; EF-hand; 1.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
DR PROSITE; PS00303; S100_CABP; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 234..256
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 78..113
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 114..149
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..24
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 261 AA; 29451 MW; 3276744F8DEBADFD CRC64;
MRLPEQPGEG KPENEKKGSG RAPEGGEEPP RSQAPDFPTW EKMPFHHVTA GLLYKGNYLN
RSLSAGSDSE QLANISVEEL DEIREAFRVL DRDGNGFISK QELGMAMRSL GYMPSEVELA
IIMQRLDMDG DGQVDFDEFM TILGPKLVSS EGRDGFLGNT IDSIFWQFDM QRITLEELKH
ILYHAFRDHL TMKDIENIII NEEESLNETS GNCQTEFEGV HSQKQNRQTC VRKSLICAFA
MAFIISVMLI AANQILRSGM E
//