ID H0V9J0_CAVPO Unreviewed; 1425 AA.
AC H0V9J0;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=Attractin {ECO:0000313|Ensembl:ENSCPOP00000006485.3};
GN Name=ATRN {ECO:0000313|Ensembl:ENSCPOP00000006485.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000006485.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000006485.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000006485.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAKN02012819; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02012820; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02012821; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02012822; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 10141.ENSCPOP00000006485; -.
DR Ensembl; ENSCPOT00000007265.3; ENSCPOP00000006485.3; ENSCPOG00000007193.4.
DR VEuPathDB; HostDB:ENSCPOG00000007193; -.
DR eggNOG; KOG1388; Eukaryota.
DR GeneTree; ENSGT00940000157346; -.
DR HOGENOM; CLU_003930_0_0_1; -.
DR InParanoid; H0V9J0; -.
DR OMA; MNGCPSD; -.
DR TreeFam; TF321873; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000007193; Expressed in frontal cortex and 12 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR GO; GO:0038023; F:signaling receptor activity; IEA:Ensembl.
DR GO; GO:0021549; P:cerebellum development; IEA:Ensembl.
DR GO; GO:0042552; P:myelination; IEA:Ensembl.
DR GO; GO:0043473; P:pigmentation; IEA:Ensembl.
DR GO; GO:0040014; P:regulation of multicellular organism growth; IEA:Ensembl.
DR CDD; cd00041; CUB; 1.
DR CDD; cd00055; EGF_Lam; 2.
DR Gene3D; 2.120.10.80; Kelch-type beta propeller; 2.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR InterPro; IPR002049; LE_dom.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR PANTHER; PTHR46376:SF3; ATTRACTIN; 1.
DR PANTHER; PTHR46376; LEUCINE-ZIPPER-LIKE TRANSCRIPTIONAL REGULATOR 1; 1.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF01344; Kelch_1; 2.
DR Pfam; PF13964; Kelch_6; 1.
DR Pfam; PF00059; Lectin_C; 1.
DR Pfam; PF01437; PSI; 2.
DR SMART; SM00034; CLECT; 1.
DR SMART; SM00042; CUB; 1.
DR SMART; SM00181; EGF; 2.
DR SMART; SM00180; EGF_Lam; 2.
DR SMART; SM00423; PSI; 5.
DR SUPFAM; SSF56436; C-type lectin-like; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF117281; Kelch motif; 1.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
DR PROSITE; PS01180; CUB; 1.
DR PROSITE; PS00022; EGF_1; 2.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS01248; EGF_LAM_1; 1.
DR PROSITE; PS50027; EGF_LAM_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Kelch repeat {ECO:0000256|ARBA:ARBA00022441};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292,
KW ECO:0000256|PROSITE-ProRule:PRU00460};
KW Lectin {ECO:0000256|ARBA:ARBA00022734};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1275..1299
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 93..126
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 128..244
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 242..279
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 791..915
FT /note="C-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50041"
FT DOMAIN 1059..1104
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DISULFID 97..107
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 116..125
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 246..256
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 250..267
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 269..278
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1076..1085
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1088..1102
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
SQ SEQUENCE 1425 AA; 158185 MW; FECB3BAE631D6630 CRC64;
MVAAAATTEA GLQSRTANIA ALAGKKGGRH RDWNVTRAER PGLGVGLRLL RLLSPSLPPR
RFLLLLLLLF LLVPWEAEAA AAAAAVSGSA ASEAKECDRP CVNGGRCNPG TGLCVCPTGW
VGEQCQHCGG RFRLTGSSGF VTDGPGNYKY KTKCTWLIEG QPNRIMRLRF NHFATECSWD
HLYVYDGDSI YAPLIAAFSG LIVPERDSNE TVPEVVVTSG YALLHFFSDA AYNLTGFNIT
YNFDMCPNNC SGRGVCKISN SSNTVECECS ENWTGESCDI PYCTDNCGFP HRGICNSSNV
RGCSCLSEWQ GPGCSVPVPA NQSFWTREEY SNLKLPRASH KAVVNGNTMW IVGGYMFNHS
DYNMVLAYDL VSKEWLPLNR SVNNVVVRYG HSLALYKDKI YMYGGKIDST GNVTNELRVF
HIHNESWVLL TPKAKEQYAV VGHSAHIVTL NTGRVVMLVI FGHCPLYGYI SNVQEYDLDK
NTWSILPTQG ALVQGGYGHS SVYDHKTKAL YVHGGYKAFS ANKYRLTDDL YRYDVDTQMW
TILKDSRFFR YLHTAVVVSG TMLVFGGNTH NDTSMSHGAK CFSSDFMAYD IACDRWSVLP
RPDLHHDVNR FGHSAVLHNS TMYVFGGFNS LLLSDILVFT SEQCESHQSE AACIAAGPGI
RCVWDTETSQ CVSWELTTEE QVIKLKSECV SKGTLDHDRC DQNTDCYSCT ANTNDCHWCN
DHCVPRNHSC TEGQISIFKY ENCPKDNPMY YCNKKTSCRS CALDQNCQWE PRNQECIALP
ENICGMGWHL VGNVCLKITT AKENYDNAKL SCRNHNAFLA SLTTQKKVEF VLKQLRMMQS
SQTMSKLTLT PWVGLRKINV SYWCWEDMSP FTNSLLQWMP SEPSDAGFCG ILSEPSNRGL
KAATCINPLN GSVCERPANH SAKQCRTPCA LRTACGECTS SSSECMWCSN MKQCVDSNAY
VASFPFGQCM EWYTMSSCPP ENCSGYCTCS HCLEQPGCGW CTDPSNTGKG KCIEGSYKGP
VKMPSQASTG IVYPQPLLNS SMCLEDGRYN WSFIHCPACQ CNGHSKCINQ SICEKCENLT
TGKHCETCIS GYYGDPTNGG KCQPCKCNGH ASLCNTNTGK CFCTTKGVKG DECQLCEVEN
RYQGNPLKGT CYYTLLIDYQ FTFSLSQEDD RYYTAINFVA TPDEQNRDLD MFINASKNFN
LNITWAASFS AGTQAGEEMP VVSKTNIKEY KDSFSNEKFD FRNHPNITFF VYVSNFTWPV
KIQIAFSQHS NFMDLVQFFV TFFSCFLSLL LVAAVVWKIK QSCWASRRRE QLLREMQQMA
SRPFASVNVA LETDEEPPDL IGGSVKTVPK PIALEPCFGN KAAVLSVFVR LPRGLGGIPP
PGQSGLAVAS ALVDISQQMP IVYKEKSGAV RNRKQQPPAQ PGTCI
//
