ID H0V9S9_CAVPO Unreviewed; 560 AA.
AC H0V9S9;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Synapsin III {ECO:0000313|Ensembl:ENSCPOP00000006584.3};
GN Name=SYN3 {ECO:0000313|Ensembl:ENSCPOP00000006584.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000006584.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000006584.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000006584.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the synapsin family.
CC {ECO:0000256|ARBA:ARBA00008243}.
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DR EMBL; AAKN02054132; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0V9S9; -.
DR STRING; 10141.ENSCPOP00000006584; -.
DR Ensembl; ENSCPOT00000007378.3; ENSCPOP00000006584.3; ENSCPOG00000007306.4.
DR VEuPathDB; HostDB:ENSCPOG00000007306; -.
DR eggNOG; KOG3895; Eukaryota.
DR GeneTree; ENSGT00940000155415; -.
DR HOGENOM; CLU_010582_3_0_1; -.
DR InParanoid; H0V9S9; -.
DR OMA; GPHKCIL; -.
DR TreeFam; TF319919; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000007306; Expressed in frontal cortex and 3 other cell types or tissues.
DR GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR GO; GO:0014069; C:postsynaptic density; IEA:Ensembl.
DR GO; GO:0030672; C:synaptic vesicle membrane; IEA:Ensembl.
DR GO; GO:0007269; P:neurotransmitter secretion; IEA:InterPro.
DR GO; GO:0097091; P:synaptic vesicle clustering; IEA:Ensembl.
DR Gene3D; 3.40.50.20; -; 1.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR InterPro; IPR016185; PreATP-grasp_dom_sf.
DR InterPro; IPR001359; Synapsin.
DR InterPro; IPR020898; Synapsin_ATP-bd_dom.
DR InterPro; IPR019736; Synapsin_P_site.
DR InterPro; IPR020897; Synapsin_pre-ATP-grasp_dom.
DR PANTHER; PTHR10841; SYNAPSIN; 1.
DR PANTHER; PTHR10841:SF27; SYNAPSIN-3; 1.
DR Pfam; PF02078; Synapsin; 1.
DR Pfam; PF02750; Synapsin_C; 1.
DR Pfam; PF10581; Synapsin_N; 1.
DR PRINTS; PR01368; SYNAPSIN.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR SUPFAM; SSF52440; PreATP-grasp domain; 1.
DR PROSITE; PS00415; SYNAPSIN_1; 1.
PE 3: Inferred from homology;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT DOMAIN 91..192
FT /note="Synapsin pre-ATP-grasp"
FT /evidence="ECO:0000259|Pfam:PF02078"
FT DOMAIN 239..375
FT /note="Synapsin ATP-binding"
FT /evidence="ECO:0000259|Pfam:PF02750"
FT REGION 17..87
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 385..547
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..69
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 422..448
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 461..506
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 514..535
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 560 AA; 60781 MW; 243F61FA25BD25AB CRC64;
MNFLRRRLSD SSFVANLPNG YMPDLQRPDS STSSPASPAT ERRHTQPLAA SFSSPGSSLF
GSFTGAMKPS ASAQAPAGPT EPAGPATPVV QRPRVLLVID DAHTDWAKYF CGKKLNGEIE
IRVEQAEFSE LNLAAYVTGG CMVDMQAVRN GTKVVRSFKP DFLLVRQHAY SMALGEDYRS
LVIGLQYGGL PAVNSLYSIY NFCSKPWVFS QLIKIFHTLG PEKFPLVEQT FFPNHKPMIK
VENQLDYQDI TSVVAMAKTY ATTEAFIDSK YDIRVQKIGS NYKAYMRTSI SGNWKANTGS
AMLEQVAMTE RYRLWVDSCS EMFGGLDICA VKAVHSKDGR DFIIEVMDSS MPLIGEHVED
DRQLMADLVV SKMNQLLVPG AAVPSTLRPW APQTKPAKSP GQGQLGPQLG QPQPRPSPQG
GPRQAQSPQT PRSGSPSQQR LSPQGQQPLS PQPGSPQPQR SPGSPQLARA SGGTSPSQAS
KPGATLPSQP RLPAQSRSTS QQGEDPKKTA PPHPHLNKSQ SLTNSLSTSD ASPHGTPSED
EAKAETIRNL RKSFASLFSD
//
