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Database: UniProt
Entry: H0VB77_CAVPO
LinkDB: H0VB77_CAVPO
Original site: H0VB77_CAVPO 
ID   H0VB77_CAVPO            Unreviewed;      4898 AA.
AC   H0VB77;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   25-OCT-2017, entry version 45.
DE   SubName: Full=Ryanodine receptor 2 {ECO:0000313|Ensembl:ENSCPOP00000007144};
GN   Name=RYR2 {ECO:0000313|Ensembl:ENSCPOP00000007144};
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricomorpha; Caviidae; Cavia.
OX   NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000007144};
RN   [1] {ECO:0000313|Ensembl:ENSCPOP00000007144}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000007144};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSCPOP00000007144}
RP   IDENTIFICATION.
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000007144};
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCPOP00000007144}.
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DR   EMBL; AAKN02021705; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02021706; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02021707; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02021708; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02021709; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02021710; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02021711; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02021712; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02021713; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 10141.ENSCPOP00000007144; -.
DR   Ensembl; ENSCPOT00000008011; ENSCPOP00000007144; ENSCPOG00000007936.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   InParanoid; H0VB77; -.
DR   OMA; EHMPNDT; -.
DR   OrthoDB; EOG091G00T0; -.
DR   TreeFam; TF315244; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   Bgee; ENSCPOG00000007936; -.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005447};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4214   4233       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4434   4454       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4509   4528       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4698   4720       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4775   4798       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       56    111       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      118    163       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      171    226       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      232    289       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      297    354       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      545    755       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      971   1168       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1283   1508       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3967   4002       EF-hand. {ECO:0000259|PROSITE:PS50222}.
SQ   SEQUENCE   4898 AA;  556591 MW;  68B4CDDC94F9A567 CRC64;
     AQNVPPDLSI CTFVLEQSLS VRALQEMLAN TVEKSEGQVD VEKWKFMMKT AQGGGHRTLL
     YGHAILLRHS YSGMYLCCLS TSRSSTDKLA FDVGLQEDTT GEACWWTIHP ASKQRSEGEK
     VRVGDDLILV SVSSERYLHL SYGTGSLHVD AAFQQTLWSV APISSGSEAA QGYLIGGDVL
     RLLHGHMDEC LTVPSGEHGE EQRRTVHYEG GAVSVHARSL WRLETLRVAW SGSHIRWGQP
     FRLRHVTTGK YLSLLEDKNL LLMDKEKADV KSTAFTFRSS KEKLDVSVRK EVDGMGTSEI
     KYGDSVCYIQ HVDTGLWLTY QSVDVKSVRM GSIQRKAIMH HEGHMDDGLN LSRSQHEESR
     TARVIRSTVF LFNRFIRGLD ALSKKVKVPA VDLPIESVSL SLQDLIGYFH PPDEHLEHED
     KQNRLRALKN RQNLFQEEGM INLVLECIDR LHVYSSAAHF ADVAGREAGE AWKSILNSLY
     ELLAALIRGN RKNCAQFSGS LDWLISRLER LEASSGILEV LHCVLVESPE ALNIIKEGHI
     KSIISLLDKH GRNHKVLDVL CSLCVCHGVA VRSNQHLICD NLLPGRDLLL QTRLVNHVSS
     MRPNIFLGIS EGSAQYKKWY YELMVDHTEP FVTAEATHLR VGWASTEGYS PYPGGGEEWG
     GNGVGDDLFS YGFDGLHLWS GCIARTVSSP NQHLLKTDDV ISCCLDLSAP SISFRINGQP
     VQGMFENFNI DGLFFPVVSF SAGIKVRFLL GGRHGEFKFL PPPGYAPCYE AVLPKEKLKV
     EHSREYKQER TYTRDLLGPT VSLTQAAFTP IPVDTTQIVL PPHLERIREK LAENIHELWV
     MNKIELGWQY GPVRDDNKRQ HPCLVEFSKL PEQERNYNLQ MSLETLKTLL ALGCHVGLSD
     EHAEEKVKKM KLPKNYQLTS GYKPAPMDLS FIKLTPAQEA MVDRLAENAH NVWARDRIRQ
     GWTYGIQQDV KNRRNPRLVP YTLLDDRTKK SNKDSLREAV RTLLGYGYNL EAPDQDHAAR
     AEVCSGTGER FRIFRAEKTY AVKAGRWYFE FEAVTAGDMR VGWSRPGCQP DQELGSDERA
     FAFDGFKAQR WHQGNEHYGR SWQAGDVVGC MVDMNEHTMM FTLNGEILLD DSGSELAFKD
     FDVGDGFIPA CSLGVAQVGR MNFGKDVSTL KYFTICGLQE GYEPFAVNTN RDITMWLSKR
     LPQFLQVPSN HEHIEVTRID GTIDSSPCLK VTQKSFGSQN SSTDLMFYRL SMPIECAEVF
     SKTMAGGLPG AGLFGPKNDL EDYDADSDFE VLMKTAHGHL VPDRVDKDKE ASKPEFNNHK
     DYAQEKPSRL KQRFLLRRTK PDYSTSHSAR LTEDVLADDR DDYDYLMQTS TYYYSVRIFP
     GQEPANVWVG WITSDFHQYD TGFDLDRVRT VTVTLGDEKG KVHESIKRSN CYMVCAGESM
     SPGQGRNNNG LEIGCVVDAA SGLLTFIANG KELSTYYQVE PSTKLFPAVF AQATSPNVFQ
     FELGRIKNVM PLSAGLFKSE HKNPVPQCPP RLHVQFLSHV LWSRMPNQFL KVDVSRISER
     QGWLVQCLDP LQFMSLHIPE ENRSVDILEL TEQEELLKFH YHTLRLYSAV CALGNHRVAH
     ALCSHVDEPQ LLYAIENKYM PGLLRSGYYD LLIDIHLSSY ATARLMMNNE FIVPMTEETK
     SITLFPDENK KHGLPGIGLS TSLRPRMQFS SPSFVSISNE CYQYSPEFPL DILKAKTMQM
     LTEAVKEGSL HARDPVGGTT EFLFVPLIKL FYTLLIMGIF HNEDLKHILQ LIEPRVFKEA
     ACVEEEGDVL EKELSTEDSK LEGAGEEDVK VGKAPKEGLL QMKLPEPVKL QMCLLLQYLC
     DCQVRHRIEA IVAFSDDFVA KLQDNQRFRY NEVMQALNMS AALTARKTKE FRSPPQEQIN
     MLLNFKDDKS ECPCPEEIRD QLLDFHEDLM THCGIELDED GSLDGNSDLT IRGRLLSLVE
     KVTYLKKKQS EKPVASDAKK SSSLQQLISE TMVRWAQESI IEDPELVRAM FVLLHRQYDG
     IGGLVRALPK TYTINGVSVE DTINLLASLG QIRSLLSVRM GKEEEKLMIR GLGDIMNNKV
     FYQHPNLMRA LGMHETVMEV MVNVLGGGES KNITFEKMHF SILNFKMYFS HYGIKSIIIH
     INPILHNLSL ESASPAMRGS TPLDVAAASV MDNNELALAL REPDLEKVVR YLAGCGLQSC
     QMLVSKGYPD IGWNPVEGER YLDFLRFAVF CNGESVEENA NVVVRLLIRR PECFGPALRG
     EGGNGLLAAM EEAIKIAEDP SRDGPSPTSG SSKTLDTEEE EDDTIHMGNA IMTFYAALID
     LLGRCAPEMH LIHAGKGEAI RIRSILRSLI PLGDLVGVIS IAFQMPTIAK DGNVVEPDMS
     AGFCPDHKAA MVLFLDRVYG IEVQDFLLHL LEVGFLPDLR AAASLDTAAL SATDMALALN
     RYLCTAVLPL LTRCAPLFAG TEHHASLIDS LLHTVYRLSK GCSLTKAQRD SIEVCLLSIC
     GQLRPSMMQH LLRRLVFDVP LLNEHAKMPL KLLTNHYERC WKYYCLPGGW GNFGAASEEE
     LHLSRKLFWG IFDALSQKKY EQELFKLALP CLSAVAGALP PDYMESNYVS MMEKQSSMDS
     EGNFNPQPVD TSNITIPEKL EYFINKYAEH SHDKWSMDKL ANGWIYGEIY SDSSKIQPLM
     KPYKLLSEKE KEIYRWPIKE SLKTMLAWGW RIERTREGDS MALYNRTRRI SQTSQVSVDA
     AHGYSPRAID MSNVTLSRDL HAMAEMMAEN YHNIWAKKKK LELESKGGGN HPLLVPYDTL
     TAKEKAKDRE KAQDILKFLQ INGYAVSRRG FKDLELDTPS IEKRFAYSFL QQLIRYVDEA
     HQYILEFDGG SRSKGEHFPY EQEIKFFAKV VLPLIDQYFK NHRLYFLSAA SRPLCSGGHA
     SNKEKEMVTS LFCKLGVLVR HRISLFGNDA TSIVNCLHIL GQTLDARTVM KTGLESVKSA
     LRAFLDNAAE DLENTMENLK QGQFTHTRNQ PKGVTQIINY TTVALLPMLS SLFEHIGQHQ
     FGEDLILEDV QVSCYRILTS LYALGTSKSI YVERQRSALG ECLAAFAGAF PVAFLETHLD
     KHNVHSIYNT KSSRERAALN LPPNVEDVCP NIPSLEKLME EIVELAESGI RYTQMPHVME
     VVLPMLCSYM SRWWEHGPEN NPERSEMCCT ALNSEHMNTL LGNILKIIYN NLGIDEGAWM
     KRLAVFSQPI INKVKPQLLK THFLPLMEKL KKKAAMVVAE EDHLKAEARG DMSEAELLIL
     DEFTTLARDL YAFYPLLIRF VDYNRAKWLK EPNPEAEELF RMVAEVFIYW SKSHNFKREE
     QNFVVQNEIN NMSFLITDTK SKMSKAAVSD QERKKMKRKG DRYSMQTSLI VAALKRLLPI
     GLNICAPGDQ ELIALAKNRF SLKDTEDEVR DIIRSNIHLQ GKLEDPAIRW QMALYKDLPN
     RTEDTSDPER TVERVLDIAN VLFHLEQKSK CIGRRYYNLV EHPQRSKKAV WHKLLSKQRK
     RAVVACFRMA PLYNLPRHRA VNLFLQGYEK SWIETEEHYF EDKLIEDLAK PGAKPPEEDE
     AAKRVDPLHQ LILLFSRTAL TEKCKLEEDF LYMAYADIMA KSCHDEEDDD GEEEVKSFEE
     KEMEKQKLLY QQARLHDRGA AEMVLQTISA SKGETGPMVA ATLKLGIAIL NGGNSTVQQK
     MLDYLKEKKD VGFFQSLAGL MQSCSVLDLN AFERQNKAEG LGMVTEEGSG EKVLQDDEFT
     CDLFRFLQLL CEGHNSDFQN YLRTQTGNNT TVNIIISTVD YLLRVQESIS DFYWYYSGKD
     VIDEQGQRNF SKAIQVAKQV FNTLTEYIQG PCTGNQQSLA HSRLWDAVVG FLHVFAHMQM
     KLSQDSSQIE LLKELMDLQK DMVVMLLSML EGNVVNGTIG KQMVDMLVES SNNVEMILKF
     FDMFLKLKDL TSSDTFKEYD PDGKGVISKR DFHKAMESHK HYTQSETEFL LSCAETDENE
     TLDYEEFVKR FHEPAKDIGF NVAVLLTNLS EHMPNDTRLQ TFLELAESVL NYFQPFLGRI
     EIMGSAKRIE RVYFEISESS RTQWEKPQVK ESKRQFIFDV VNEGGEKEKM ELFVNFCEDT
     IFEMQLAAQI SESDLNERST NKEESEKERL EEQGPRMGFF SILTVRSALL ALRYNILTLM
     RMLSLKSLTM KDMVTAFFSS YWSVFVTLLH FVASVCRGFF RIVCSLLLGG SLVEGAKKIK
     VAELLANMPD PTQDEVRGDG EEGERKPMET PLPSEDLTDL KELAEESDLL SDIFGLDLKR
     EGGQYKLIPH NPNAGLGDLM SNPVPIPEVQ EKFQERSGFL LNKEHKLTLK SEPEKAEGED
     GEKEEKAKED KGKQKLRQLH THRYGEPEVP ESAFWKKIIA YQQKLLNYFA RNFYNMRMLA
     LFVAFAINFI LLFYKVSTAS VAEGKELPTR SPSESAKVTT SLDSSSHRII AVHYVLEESS
     GYMEPTLRIL AILHTVISFF CIIGYYCLKV PLVIFKREKE VARKLEFDGL YITEQPSEDD
     IKGQWDRLVI NTQSFPNNYW DKFVKRKVMD KYGEFYGRDR ISELLGMDKA ALDFSDAREK
     KKPKKDSSLS AVLNSIDVKY QMWKLGVVFT DNSFLYLAWY MTMSVLGHYN TAHLLDIAMG
     FKTLRTILSS VTHNGKQLVL TVGLLAVVVY LYTVVAFNFF RKFYNKSEDG DTPDMKCDDM
     LTCYMFHMYV GVRAGGGIGD EIEDPAGDEY EIYRIIFDIT FFFFVIVILL AIIQGLIIDA
     FGELRDQQEQ VKEDMETKCF ICGIGNDYFD TVPHGFETHT LQEHNLANYL FFLMYLINKD
     ETEHTGQESY VWKMYQERCW EFFPAGDCFR KQYEDQLN
//
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