ID H0VF44_CAVPO Unreviewed; 344 AA.
AC H0VF44;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Opticin {ECO:0000313|Ensembl:ENSCPOP00000008670.3};
GN Name=OPTC {ECO:0000313|Ensembl:ENSCPOP00000008670.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000008670.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000008670.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000008670.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the small leucine-rich proteoglycan (SLRP)
CC family. SLRP class III subfamily. {ECO:0000256|ARBA:ARBA00006912}.
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DR EMBL; AAKN02017924; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0VF44; -.
DR STRING; 10141.ENSCPOP00000008670; -.
DR Ensembl; ENSCPOT00000009745.3; ENSCPOP00000008670.3; ENSCPOG00000009658.4.
DR VEuPathDB; HostDB:ENSCPOG00000009658; -.
DR GeneTree; ENSGT00940000154248; -.
DR HOGENOM; CLU_067583_2_0_1; -.
DR InParanoid; H0VF44; -.
DR TreeFam; TF351924; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000009658; Expressed in uterine cervix.
DR GO; GO:0031012; C:extracellular matrix; IEA:Ensembl.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR043547; Mimecan/Epiphycan/Opticin.
DR PANTHER; PTHR46269; EPIPHYCAN-RELATED; 1.
DR PANTHER; PTHR46269:SF4; OPTICIN; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13855; LRR_8; 1.
DR SMART; SM00364; LRR_BAC; 3.
DR SMART; SM00369; LRR_TYP; 5.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS51450; LRR; 2.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REGION 1..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 73..93
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 73..87
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 344 AA; 37847 MW; A7148048EADEEEDD CRC64;
PQPKPAQSTS PSESLPPWKL LEPKASKGSC PSSCPLPRAG HSHSHPHFRT HMRLAAFLSV
LGLVLQEAGT ASLAEERKRR EEPRLSLGDS SEVTGLRNCE HHEGLTDCRD RLPESQAATM
KPDQGSPSVL SSSGSGLPTC LVCVCLGPSV YCDDTDLGSI PPVPRMTTYL YARFNRISRI
RAGDFRGLTK LKRLDLSSNF ISAIDDDALH LLPALQDLIL SENQLVALPV LPSSIELLDV
RLNRLRSSGI QPGAFGALQK LQFLYLADNR LDSVPGPLPL SLRSLHLQNN MIETMPSDAF
CDLEEHRHTR RLLEDIRLDG NPIDLSLFPS AYFCLPRLPI GRFT
//
