ID H0VGV7_CAVPO Unreviewed; 1166 AA.
AC H0VGV7;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Tectonin beta-propeller repeat containing 1 {ECO:0000313|Ensembl:ENSCPOP00000009366.3};
GN Name=TECPR1 {ECO:0000313|Ensembl:ENSCPOP00000009366.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000009366.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000009366.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000009366.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TECPR1 family.
CC {ECO:0000256|ARBA:ARBA00005966}.
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DR EMBL; AAKN02032155; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003469934.1; XM_003469886.3.
DR RefSeq; XP_013008095.1; XM_013152641.1.
DR STRING; 10141.ENSCPOP00000023271; -.
DR Ensembl; ENSCPOT00000010524.3; ENSCPOP00000009366.3; ENSCPOG00000010430.4.
DR Ensembl; ENSCPOT00000044241.1; ENSCPOP00000023271.1; ENSCPOG00000010430.4.
DR GeneID; 100715411; -.
DR KEGG; cpoc:100715411; -.
DR CTD; 25851; -.
DR VEuPathDB; HostDB:ENSCPOG00000010430; -.
DR eggNOG; KOG3669; Eukaryota.
DR GeneTree; ENSGT00510000047886; -.
DR HOGENOM; CLU_008303_0_0_1; -.
DR OMA; CPMQISR; -.
DR OrthoDB; 66441at2759; -.
DR TreeFam; TF323648; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000010430; Expressed in adrenal gland and 13 other cell types or tissues.
DR GO; GO:0000421; C:autophagosome membrane; IEA:Ensembl.
DR GO; GO:0005765; C:lysosomal membrane; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; IEA:Ensembl.
DR GO; GO:0097352; P:autophagosome maturation; IEA:Ensembl.
DR GO; GO:1901096; P:regulation of autophagosome maturation; IEA:Ensembl.
DR CDD; cd13300; PH1_TECPR1; 1.
DR InterPro; IPR006624; Beta-propeller_rpt_TECPR.
DR InterPro; IPR010482; Peroxin.
DR InterPro; IPR006614; Peroxin/Ferlin.
DR PANTHER; PTHR23250; DYSFERLIN-RELATED; 1.
DR PANTHER; PTHR23250:SF1; TECTONIN BETA-PROPELLER REPEAT-CONTAINING PROTEIN 1; 1.
DR Pfam; PF06462; Hyd_WA; 2.
DR Pfam; PF06398; Pex24p; 2.
DR Pfam; PF19193; Tectonin; 2.
DR SMART; SM00694; DysFC; 2.
DR SMART; SM00693; DysFN; 2.
DR SMART; SM00706; TECPR; 11.
DR SUPFAM; SSF50729; PH domain-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..1166
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014092398"
FT DOMAIN 64..125
FT /note="Peroxin/Ferlin"
FT /evidence="ECO:0000259|SMART:SM00693"
FT DOMAIN 137..170
FT /note="Peroxin/Ferlin"
FT /evidence="ECO:0000259|SMART:SM00694"
FT DOMAIN 820..881
FT /note="Peroxin/Ferlin"
FT /evidence="ECO:0000259|SMART:SM00693"
FT DOMAIN 892..925
FT /note="Peroxin/Ferlin"
FT /evidence="ECO:0000259|SMART:SM00694"
FT REGION 403..452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 467..486
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 419..446
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1166 AA; 129743 MW; 3AE2BC19D940707D CRC64;
MPTSVLWAVD LFGRVYTLST AGQYWELCRD TQLEFKRVSA ATQCCWGIAC DNQVYLYMCA
SDVSIRCREE AYENQRWNPM GGFCEKLLPS DRWAWSDVSG LQHRPLDGVA LPSPHWEWES
DWYVDENFGG EPTEKGGWTY AIDFPATYTR DKKWNSCVRR RKWIRYRRYK SRDAWAKIPS
KDDVKDLPDP FNDLSVGGWE ITEEPVGRLS VWAVSLQGKV WYREDVSHPN PEGSSWSLVD
TPGEAVQISC GPHDLLWVTL WEGQALVREG INRNNPKGSS WSVVEPPGSE NGIMHVSAGV
SVVWAVTKDR KVWFRRGVNS HNPGGTSWIE MVGEMTMVNV GLNDQVWGIG AEERAVYFRQ
GVTPSELSGK TWKAIVAGRE SDRSHTGSSS SLLSAGCFFG DEVKGNSESA PSDTDTTSEA
ERSGPEHSAP QEPLDSSRDH KDNSALGPET EGTAECILEN TCPDVEGKEA AQASVTSEHP
NLASAPAELP WTNIDLKEPR KVPSHSAAGF AETVGLSSLG LFPLGLDEPF GADDHPLWAW
VSGGGCAVEA GSALKWFTVQ SGLSPSVQTL SLSISPAQTA AWRKQIFQQL TERTKRELEN
FRHYEQAVEQ SVWVKTGTLQ WWCDWKPHKW VDVRVALEQF TGHDGARDSI LFVYYIVHEE
KKYFHVFLNE VTVLVPVLNE AKHSFALYTA ERTRQRWPVR LAAATEQDMN DWLALLSLSC
CESRKIHGRP SPQAIWSVTC KGDIFVSEPS SDLEAQDHLL PCDQMFWRQM GGHLRMVEAN
SRGVVWGIGY DHTAWVYTGG YGGGCFQGLA SSTSNIYTQS DVKSICIYEN QRWNPVTGYT
SRGLPTDRYM WSDATGLQEC TKASTKPPSL QWTWVSDWYV DFSVPGGTDQ EGWQYASDFP
ASYHGYKTMK DFVRRRCWAR KCKLVTNGPW LEVAPIALGD VSIIPESPES TDGDGRSHNI
ALWAVSDKGD VLCRLGVSEL NPVGSSWLHI GTDQPFASVS IGACYQVWAV ARDGSAFYRG
SVSPSQPAGD CWYHIPSPPK QRLVQVSVGQ TSVYALDENG NLWYRAGVTP SYPQGSSWEH
VSNNVRKVSV GPLDQVWVIA NKVQGTHGLS RGTVCRRTGV QPREPKGQGW DYGIGGGWDH
ISIRANATRA SRNVSQEQKV PGPVSC
//
