ID H0VGZ1_CAVPO Unreviewed; 373 AA.
AC H0VGZ1;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=ELAV-like protein {ECO:0000256|RuleBase:RU361281};
GN Name=ELAVL2 {ECO:0000313|Ensembl:ENSCPOP00000009403.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000009403.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000009403.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000009403.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the RRM elav family.
CC {ECO:0000256|ARBA:ARBA00006266, ECO:0000256|RuleBase:RU361281}.
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DR EMBL; AAKN02003635; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02003636; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02003637; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0VGZ1; -.
DR Ensembl; ENSCPOT00000010566.3; ENSCPOP00000009403.3; ENSCPOG00000010472.4.
DR VEuPathDB; HostDB:ENSCPOG00000010472; -.
DR eggNOG; KOG0145; Eukaryota.
DR GeneTree; ENSGT00940000156823; -.
DR HOGENOM; CLU_026186_2_2_1; -.
DR TreeFam; TF313377; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000010472; Expressed in hypothalamus and 7 other cell types or tissues.
DR GO; GO:1990904; C:ribonucleoprotein complex; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd12771; RRM1_HuB; 1.
DR CDD; cd12775; RRM2_HuB; 1.
DR CDD; cd12654; RRM3_HuB; 1.
DR Gene3D; 3.30.70.330; -; 3.
DR InterPro; IPR006548; ELAD_HU_SF.
DR InterPro; IPR034999; HuB_RRM2.
DR InterPro; IPR034914; HuB_RRM3.
DR InterPro; IPR002343; Hud_Sxl_RNA.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR NCBIfam; TIGR01661; ELAV_HUD_SF; 1.
DR PANTHER; PTHR10352; EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G; 1.
DR Pfam; PF00076; RRM_1; 3.
DR PRINTS; PR00961; HUDSXLRNA.
DR SMART; SM00360; RRM; 3.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 2.
DR PROSITE; PS50102; RRM; 3.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00176}.
FT DOMAIN 53..131
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 139..219
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 290..368
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
SQ SEQUENCE 373 AA; 41067 MW; 2853AE0359D7CB2A CRC64;
MTKQYEVAVQ VIAAMETQLS NGPTCNNTTN GPTTINNNCS SPVDSGNTED SKTNLIVNYL
PQNMTQEELK SLFGSIGEIE SCKLVRDKIT GQSLGYGFVN YIDPKDAEKA INTLNGLRLQ
TKTIKVSYAR PSSASIRDAN LYVSGLPKTM TQKELEQLFS QYGRIITSRI LVDQVTGISR
GVGFIRFDKR IEAEEAIKGL NGQKPPGATE PITVKFANNP SQKTNQAILS QLYQSPNRRY
PGPLAQQAQR FRLDNLLNMA YGVKRFSPMT IDGMTSLAGI NIPGHPGTGW CIFVYNLAPD
ADESILWQMF GPFGAVTNVK VIRDFNTNKC KGFGFVTMTN YDEAAMAIAS LNGYRLGDRV
LQVSFKTNKT HKA
//
