ID H0VK69_CAVPO Unreviewed; 493 AA.
AC H0VK69;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=Sorting nexin-30 {ECO:0000256|ARBA:ARBA00015234};
GN Name=SNX30 {ECO:0000313|Ensembl:ENSCPOP00000010679.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000010679.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000010679.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000010679.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Heterodimer; heterodimerizes with SNX4.
CC {ECO:0000256|ARBA:ARBA00038663}.
CC -!- SUBCELLULAR LOCATION: Early endosome membrane
CC {ECO:0000256|ARBA:ARBA00004469}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004469}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004469}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004125}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004125}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004125}.
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883}.
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DR EMBL; AAKN02049991; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02049992; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02049993; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003463867.2; XM_003463819.3.
DR AlphaFoldDB; H0VK69; -.
DR STRING; 10141.ENSCPOP00000010679; -.
DR Ensembl; ENSCPOT00000011988.3; ENSCPOP00000010679.3; ENSCPOG00000011873.4.
DR GeneID; 100718081; -.
DR KEGG; cpoc:100718081; -.
DR CTD; 401548; -.
DR VEuPathDB; HostDB:ENSCPOG00000011873; -.
DR eggNOG; KOG2273; Eukaryota.
DR GeneTree; ENSGT00940000158994; -.
DR InParanoid; H0VK69; -.
DR OMA; WSLHRFI; -.
DR OrthoDB; 5475877at2759; -.
DR TreeFam; TF328543; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000011873; Expressed in uterine cervix and 11 other cell types or tissues.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:2000786; P:positive regulation of autophagosome assembly; IEA:Ensembl.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd07667; BAR_SNX30; 1.
DR CDD; cd06860; PX_SNX7_30_like; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR028649; SNX30_BAR.
DR PANTHER; PTHR45949:SF1; SORTING NEXIN-30; 1.
DR PANTHER; PTHR45949; SORTING NEXIN-4; 1.
DR Pfam; PF03114; BAR; 1.
DR Pfam; PF00787; PX; 1.
DR SMART; SM00312; PX; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS50195; PX; 1.
PE 3: Inferred from homology;
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Transport {ECO:0000256|ARBA:ARBA00022927}.
FT DOMAIN 145..266
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT REGION 1..101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 493 AA; 55278 MW; 37A58D29CE94A892 CRC64;
MPLGLRAAPP SAGLPKASSD SCSTGQRAGR AFPAARRPGE GLQPLAPPPS CSHLSRPLTL
PHSPSPSRAA RVPRGWSREG WAGGGAGGEQ RPGTPSPDLL VARSFGDKDL ILPNGGTPAG
ASSPASSSSL LNRLQLDDDI DGETRDLFVT VDDPKKHVCT METYITYRIT TKSTRAEFDL
PEYSVRRRYQ DFDWLRSKLE ESQPTHLIPP LPEKFVVKGV VDRFSEEFVE TRRKALDKFL
KRITDHPVLS FNEHFNVFLT AKDLNAYRKQ GMALLTRVGE SVKHVTGGYK LRSRPLEFAA
IGEYLDTFAL KLGTIDRIAQ RIIKEEIDYL VELREYGPVY STWSALEGEL AEPLEGVSAC
IGNCSAALEE LTDDMTEDFL PVLREYILYS DSMKSVLKKR DQVQAEYEAK LEAVALRKED
RPKVPADVEK CQDRVECFNA DLKADMERWQ NNKRQDFRQL LMGLADKNIQ YYEKCLMAWE
SIIPLLQEKQ EGK
//
