ID H0VL72_CAVPO Unreviewed; 797 AA.
AC H0VL72;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=E3 ubiquitin-protein ligase RNF10 {ECO:0000256|ARBA:ARBA00035131};
DE AltName: Full=RING finger protein 10 {ECO:0000256|ARBA:ARBA00035390};
GN Name=RNF10 {ECO:0000313|Ensembl:ENSCPOP00000011094.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000011094.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000011094.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000011094.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the RNF10 family.
CC {ECO:0000256|ARBA:ARBA00008117}.
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DR EMBL; AAKN02007154; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02007155; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02007156; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0VL72; -.
DR STRING; 10141.ENSCPOP00000011094; -.
DR Ensembl; ENSCPOT00000012448.3; ENSCPOP00000011094.3; ENSCPOG00000012331.4.
DR VEuPathDB; HostDB:ENSCPOG00000012331; -.
DR eggNOG; KOG2164; Eukaryota.
DR GeneTree; ENSGT00390000001731; -.
DR HOGENOM; CLU_018206_0_0_1; -.
DR InParanoid; H0VL72; -.
DR OMA; PKQELWP; -.
DR TreeFam; TF323455; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000012331; Expressed in testis and 13 other cell types or tissues.
DR GO; GO:0022626; C:cytosolic ribosome; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:Ensembl.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0051865; P:protein autoubiquitination; IEA:Ensembl.
DR GO; GO:0006513; P:protein monoubiquitination; IEA:Ensembl.
DR GO; GO:1990116; P:ribosome-associated ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR CDD; cd16536; RING-HC_RNF10; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR039739; MAG2/RNF10.
DR InterPro; IPR027370; Znf-RING_euk.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR12983; RING FINGER 10 FAMILY MEMBER; 1.
DR PANTHER; PTHR12983:SF9; RING FINGER PROTEIN 10; 1.
DR Pfam; PF13445; zf-RING_UBOX; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 222..263
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 55..112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 582..604
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 639..658
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 718..747
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 762..797
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..35
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 70..108
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 797 AA; 88881 MW; C3FAF8B43A50C453 CRC64;
MPQSSPNAAA TASDMDKNSG SNNSSASSGS SKGNSRPAPI LILLCFLFSD GKNSNGSKRY
NRKREPSYPK NENFSNQSRR SNAQKSKTFN KMPPQRGGGS SKLFSSSFNG GRRDEVAEAQ
RAEFSPAQFS GPKKINLNHL LNFTFEPRGQ AGHFEGSGHG SWGKRNKWGH KPFNKELFLQ
ANCQFVVSED QDYTAHFADP DTLVNWDFVE QVRICSHEVP SCPICLYPPT AAKITRCGHI
FCWACILHYL SLSEKTWSKC PICYSSVHKK DLKSVVATES RQYVVGDTIT MQLMKREKGV
LVALPKSKWM NVDHPIHLGD EQHSQYSKLL LASKEQVLHR VVLEEKVALE RQLAEEKHTP
ESCFIEAAIQ ELKTREEALS GLAESRKEVP GVVSALEQLV LMAPLAKEPV FRPRKQGVLE
YLSAFDEETV EVCSVDSPRP LALPLVEEEE VVSEPEPEAD DNLGEGTICI ETSQQEPVTK
PGFTHLSSSP CYYFYQAEDG QHMFLHPINV RCLVREYGSL EQSPEKISAT VVEIAGYSMS
EDVRQRHRYL SHLPLTCEFS LCELALQPPV VSKETLEMFS DDIEKRKRQR QKKAREERRR
ERRIEMEENK KQGKYPEVHI PLENLQQFPA FNSYTCSSDS ALGPTSTEGH GSLSLSTLSR
SPGSHADFLL TPLSPTASQG SPSFCVGSLE EDSPFPSFAQ MLRVGKAKAD VWPKTALKKD
ENSLVPPAPV DSDGESDNSD RVPVPSFQNS FSQAIEAAFM KLDTPATSDP LSEEKGGKKR
KKQKQKLLFS TSVVHTK
//
