ID H0VM83_CAVPO Unreviewed; 423 AA.
AC H0VM83;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Galactose-3-O-sulfotransferase 1 {ECO:0000313|Ensembl:ENSCPOP00000011507.3};
GN Name=GAL3ST1 {ECO:0000313|Ensembl:ENSCPOP00000011507.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000011507.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000011507.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000011507.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the galactose-3-O-sulfotransferase family.
CC {ECO:0000256|ARBA:ARBA00008124}.
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DR EMBL; AAKN02007250; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_012997429.1; XM_013141975.1.
DR AlphaFoldDB; H0VM83; -.
DR STRING; 10141.ENSCPOP00000011507; -.
DR Ensembl; ENSCPOT00000012912.3; ENSCPOP00000011507.3; ENSCPOG00000012787.4.
DR GeneID; 100735507; -.
DR CTD; 9514; -.
DR VEuPathDB; HostDB:ENSCPOG00000012787; -.
DR eggNOG; ENOG502QTXT; Eukaryota.
DR GeneTree; ENSGT00950000182923; -.
DR HOGENOM; CLU_040616_1_1_1; -.
DR InParanoid; H0VM83; -.
DR OMA; CAPKVDI; -.
DR OrthoDB; 3032344at2759; -.
DR TreeFam; TF314802; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000012787; Expressed in adult mammalian kidney and 7 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0001733; F:galactosylceramide sulfotransferase activity; IEA:Ensembl.
DR GO; GO:0006682; P:galactosylceramide biosynthetic process; IEA:Ensembl.
DR GO; GO:0046486; P:glycerolipid metabolic process; IEA:Ensembl.
DR GO; GO:0042552; P:myelination; IEA:Ensembl.
DR GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR009729; Gal-3-0_sulfotransfrase.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR14647; GALACTOSE-3-O-SULFOTRANSFERASE; 1.
DR PANTHER; PTHR14647:SF56; GALACTOSYLCERAMIDE SULFOTRANSFERASE; 1.
DR Pfam; PF06990; Gal-3-0_sulfotr; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT REGION 46..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 48..62
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 423 AA; 49074 MW; FA2973B365369588 CRC64;
MPPLPKKRWE SMAKGLVLGA LFTSFLLLLY SYAVPPLHAG LASTTPEDMA PCSPSPSESE
LVNPARGSAR ECQPQRDIVF MKTHKTASST LLNILFRFGQ KHRLKFAFPS GRNDFDYPAF
FERSLVQDYQ PGACFNIICN HMRFHYQEVR GLVPPNATFI TVLRDPARLF ESSFHYFGSV
VPLTWKLSSQ DKLAEFLQDP DRYYDPNGYN AHYLRNLLFF DLGYDSSLDP SSPQVEEHIL
EVERRFHLVL LQEYFDESLV LLKDLLCWEL EDVLYFKLNA RRDSPVPRLS GELYRRATAW
NMLDARLYRH FNASFWHKVE AFGRERMAHE VAALRSANEH MRRICIDGGQ AVDAAAIQDS
AMQPWQPLGT KSILGYNLKK SIGRRHEQLC RRMLTPEIQY LMDLGANLWV TKLWKLIRDF
LRW
//
