ID H0VMM7_CAVPO Unreviewed; 2472 AA.
AC H0VMM7;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 89.
DE RecName: Full=Neurogenic locus notch homolog protein 1 {ECO:0000256|ARBA:ARBA00019142};
GN Name=NOTCH1 {ECO:0000313|Ensembl:ENSCPOP00000011665.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000011665.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000011665.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000011665.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the NOTCH family.
CC {ECO:0000256|ARBA:ARBA00005847}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; AAKN02024169; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 10141.ENSCPOP00000011665; -.
DR Ensembl; ENSCPOT00000013083.3; ENSCPOP00000011665.3; ENSCPOG00000012958.4.
DR VEuPathDB; HostDB:ENSCPOG00000012958; -.
DR GeneTree; ENSGT00940000157157; -.
DR HOGENOM; CLU_000576_2_0_1; -.
DR InParanoid; H0VMM7; -.
DR OMA; TCHEQRD; -.
DR TreeFam; TF351641; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000012958; Expressed in zone of skin and 12 other cell types or tissues.
DR GO; GO:0005912; C:adherens junction; IEA:Ensembl.
DR GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR GO; GO:0031410; C:cytoplasmic vesicle; IEA:Ensembl.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0002193; C:MAML1-RBP-Jkappa- ICN1 complex; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0043235; C:receptor complex; IEA:Ensembl.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0031490; F:chromatin DNA binding; IEA:Ensembl.
DR GO; GO:0000987; F:cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0019899; F:enzyme binding; IEA:Ensembl.
DR GO; GO:0004857; F:enzyme inhibitor activity; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0005112; F:Notch binding; IEA:Ensembl.
DR GO; GO:0003713; F:transcription coactivator activity; IEA:Ensembl.
DR GO; GO:0140537; F:transcription regulator activator activity; IEA:Ensembl.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:Ensembl.
DR GO; GO:0003180; P:aortic valve morphogenesis; IEA:Ensembl.
DR GO; GO:1902263; P:apoptotic process involved in embryonic digit morphogenesis; IEA:Ensembl.
DR GO; GO:0060842; P:arterial endothelial cell differentiation; IEA:Ensembl.
DR GO; GO:0003162; P:atrioventricular node development; IEA:Ensembl.
DR GO; GO:0009912; P:auditory receptor cell fate commitment; IEA:Ensembl.
DR GO; GO:0007409; P:axonogenesis; IEA:Ensembl.
DR GO; GO:0048754; P:branching morphogenesis of an epithelial tube; IEA:Ensembl.
DR GO; GO:0017156; P:calcium-ion regulated exocytosis; IEA:Ensembl.
DR GO; GO:0003214; P:cardiac left ventricle morphogenesis; IEA:Ensembl.
DR GO; GO:0060379; P:cardiac muscle cell myoblast differentiation; IEA:Ensembl.
DR GO; GO:0060038; P:cardiac muscle cell proliferation; IEA:Ensembl.
DR GO; GO:0003213; P:cardiac right atrium morphogenesis; IEA:Ensembl.
DR GO; GO:0003219; P:cardiac right ventricle formation; IEA:Ensembl.
DR GO; GO:0060948; P:cardiac vascular smooth muscle cell development; IEA:Ensembl.
DR GO; GO:0003273; P:cell migration involved in endocardial cushion formation; IEA:Ensembl.
DR GO; GO:0071372; P:cellular response to follicle-stimulating hormone stimulus; IEA:Ensembl.
DR GO; GO:0071456; P:cellular response to hypoxia; IEA:Ensembl.
DR GO; GO:0071228; P:cellular response to tumor cell; IEA:Ensembl.
DR GO; GO:0035924; P:cellular response to vascular endothelial growth factor stimulus; IEA:Ensembl.
DR GO; GO:0072044; P:collecting duct development; IEA:Ensembl.
DR GO; GO:0007386; P:compartment pattern specification; IEA:Ensembl.
DR GO; GO:0060982; P:coronary artery morphogenesis; IEA:Ensembl.
DR GO; GO:0003182; P:coronary sinus valve morphogenesis; IEA:Ensembl.
DR GO; GO:0003169; P:coronary vein morphogenesis; IEA:Ensembl.
DR GO; GO:0072017; P:distal tubule development; IEA:Ensembl.
DR GO; GO:0035116; P:embryonic hindlimb morphogenesis; IEA:Ensembl.
DR GO; GO:0060956; P:endocardial cell differentiation; IEA:Ensembl.
DR GO; GO:0003160; P:endocardium morphogenesis; IEA:Ensembl.
DR GO; GO:0007492; P:endoderm development; IEA:Ensembl.
DR GO; GO:0009957; P:epidermal cell fate specification; IEA:Ensembl.
DR GO; GO:0072148; P:epithelial cell fate commitment; IEA:Ensembl.
DR GO; GO:0050673; P:epithelial cell proliferation; IEA:Ensembl.
DR GO; GO:0003198; P:epithelial to mesenchymal transition involved in endocardial cushion formation; IEA:Ensembl.
DR GO; GO:0030900; P:forebrain development; IEA:Ensembl.
DR GO; GO:0007440; P:foregut morphogenesis; IEA:Ensembl.
DR GO; GO:0072144; P:glomerular mesangial cell development; IEA:Ensembl.
DR GO; GO:0003241; P:growth involved in heart morphogenesis; IEA:Ensembl.
DR GO; GO:0031069; P:hair follicle morphogenesis; IEA:Ensembl.
DR GO; GO:0001947; P:heart looping; IEA:Ensembl.
DR GO; GO:0048873; P:homeostasis of number of cells within a tissue; IEA:Ensembl.
DR GO; GO:0006959; P:humoral immune response; IEA:Ensembl.
DR GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl.
DR GO; GO:0002437; P:inflammatory response to antigenic stimulus; IEA:Ensembl.
DR GO; GO:0002085; P:inhibition of neuroepithelial cell differentiation; IEA:Ensembl.
DR GO; GO:0097400; P:interleukin-17-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0030216; P:keratinocyte differentiation; IEA:Ensembl.
DR GO; GO:0070986; P:left/right axis specification; IEA:Ensembl.
DR GO; GO:0001889; P:liver development; IEA:Ensembl.
DR GO; GO:0030324; P:lung development; IEA:Ensembl.
DR GO; GO:0014031; P:mesenchymal cell development; IEA:Ensembl.
DR GO; GO:0003192; P:mitral valve formation; IEA:Ensembl.
DR GO; GO:2000811; P:negative regulation of anoikis; IEA:Ensembl.
DR GO; GO:0070168; P:negative regulation of biomineral tissue development; IEA:Ensembl.
DR GO; GO:0030514; P:negative regulation of BMP signaling pathway; IEA:Ensembl.
DR GO; GO:0045955; P:negative regulation of calcium ion-dependent exocytosis; IEA:Ensembl.
DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:0010614; P:negative regulation of cardiac muscle hypertrophy; IEA:Ensembl.
DR GO; GO:0060354; P:negative regulation of cell adhesion molecule production; IEA:Ensembl.
DR GO; GO:0090051; P:negative regulation of cell migration involved in sprouting angiogenesis; IEA:Ensembl.
DR GO; GO:0003252; P:negative regulation of cell proliferation involved in heart valve morphogenesis; IEA:Ensembl.
DR GO; GO:2000048; P:negative regulation of cell-cell adhesion mediated by cadherin; IEA:Ensembl.
DR GO; GO:0010812; P:negative regulation of cell-substrate adhesion; IEA:Ensembl.
DR GO; GO:0120163; P:negative regulation of cold-induced thermogenesis; IEA:Ensembl.
DR GO; GO:2001027; P:negative regulation of endothelial cell chemotaxis; IEA:Ensembl.
DR GO; GO:0050680; P:negative regulation of epithelial cell proliferation; IEA:Ensembl.
DR GO; GO:0003332; P:negative regulation of extracellular matrix constituent secretion; IEA:Ensembl.
DR GO; GO:0010629; P:negative regulation of gene expression; IEA:Ensembl.
DR GO; GO:0060253; P:negative regulation of glial cell proliferation; IEA:Ensembl.
DR GO; GO:0045608; P:negative regulation of inner ear auditory receptor cell differentiation; IEA:Ensembl.
DR GO; GO:0045662; P:negative regulation of myoblast differentiation; IEA:Ensembl.
DR GO; GO:0010832; P:negative regulation of myotube differentiation; IEA:Ensembl.
DR GO; GO:0048715; P:negative regulation of oligodendrocyte differentiation; IEA:Ensembl.
DR GO; GO:0030279; P:negative regulation of ossification; IEA:Ensembl.
DR GO; GO:0045668; P:negative regulation of osteoblast differentiation; IEA:Ensembl.
DR GO; GO:0046533; P:negative regulation of photoreceptor cell differentiation; IEA:Ensembl.
DR GO; GO:2000974; P:negative regulation of pro-B cell differentiation; IEA:Ensembl.
DR GO; GO:2000737; P:negative regulation of stem cell differentiation; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0021915; P:neural tube development; IEA:Ensembl.
DR GO; GO:0061101; P:neuroendocrine cell differentiation; IEA:Ensembl.
DR GO; GO:0097150; P:neuronal stem cell population maintenance; IEA:Ensembl.
DR GO; GO:0003270; P:Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation; IEA:Ensembl.
DR GO; GO:0048709; P:oligodendrocyte differentiation; IEA:Ensembl.
DR GO; GO:0003151; P:outflow tract morphogenesis; IEA:Ensembl.
DR GO; GO:0003344; P:pericardium morphogenesis; IEA:Ensembl.
DR GO; GO:1903849; P:positive regulation of aorta morphogenesis; IEA:Ensembl.
DR GO; GO:1902339; P:positive regulation of apoptotic process involved in morphogenesis; IEA:Ensembl.
DR GO; GO:0048711; P:positive regulation of astrocyte differentiation; IEA:Ensembl.
DR GO; GO:0030513; P:positive regulation of BMP signaling pathway; IEA:Ensembl.
DR GO; GO:0060045; P:positive regulation of cardiac muscle cell proliferation; IEA:Ensembl.
DR GO; GO:0030335; P:positive regulation of cell migration; IEA:Ensembl.
DR GO; GO:0050679; P:positive regulation of epithelial cell proliferation; IEA:Ensembl.
DR GO; GO:0010718; P:positive regulation of epithelial to mesenchymal transition; IEA:Ensembl.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
DR GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR GO; GO:0045618; P:positive regulation of keratinocyte differentiation; IEA:Ensembl.
DR GO; GO:0045747; P:positive regulation of Notch signaling pathway; IEA:Ensembl.
DR GO; GO:0046579; P:positive regulation of Ras protein signal transduction; IEA:Ensembl.
DR GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; IEA:Ensembl.
DR GO; GO:0051152; P:positive regulation of smooth muscle cell differentiation; IEA:Ensembl.
DR GO; GO:0007221; P:positive regulation of transcription of Notch receptor target; IEA:Ensembl.
DR GO; GO:0045070; P:positive regulation of viral genome replication; IEA:Ensembl.
DR GO; GO:0060740; P:prostate gland epithelium morphogenesis; IEA:Ensembl.
DR GO; GO:0030163; P:protein catabolic process; IEA:Ensembl.
DR GO; GO:0006606; P:protein import into nucleus; IEA:Ensembl.
DR GO; GO:0003184; P:pulmonary valve morphogenesis; IEA:Ensembl.
DR GO; GO:0061344; P:regulation of cell adhesion involved in heart morphogenesis; IEA:Ensembl.
DR GO; GO:0060768; P:regulation of epithelial cell proliferation involved in prostate gland development; IEA:Ensembl.
DR GO; GO:1901201; P:regulation of extracellular matrix assembly; IEA:Ensembl.
DR GO; GO:0014807; P:regulation of somitogenesis; IEA:Ensembl.
DR GO; GO:0072091; P:regulation of stem cell proliferation; IEA:Ensembl.
DR GO; GO:0032495; P:response to muramyl dipeptide; IEA:Ensembl.
DR GO; GO:0042670; P:retinal cone cell differentiation; IEA:Ensembl.
DR GO; GO:0060528; P:secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development; IEA:Ensembl.
DR GO; GO:0035914; P:skeletal muscle cell differentiation; IEA:Ensembl.
DR GO; GO:0048103; P:somatic stem cell division; IEA:Ensembl.
DR GO; GO:0002040; P:sprouting angiogenesis; IEA:Ensembl.
DR GO; GO:0072538; P:T-helper 17 type immune response; IEA:Ensembl.
DR GO; GO:0006366; P:transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0035148; P:tube formation; IEA:Ensembl.
DR GO; GO:0060979; P:vasculogenesis involved in coronary vascular morphogenesis; IEA:Ensembl.
DR GO; GO:0060843; P:venous endothelial cell differentiation; IEA:Ensembl.
DR GO; GO:0060412; P:ventricular septum morphogenesis; IEA:Ensembl.
DR GO; GO:0003222; P:ventricular trabecula myocardium morphogenesis; IEA:Ensembl.
DR CDD; cd00054; EGF_CA; 27.
DR CDD; cd21702; JMTM_Notch1; 1.
DR Gene3D; 3.30.300.320; -; 1.
DR Gene3D; 3.30.70.3310; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 2.10.25.10; Laminin; 32.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR008297; Notch.
DR InterPro; IPR035993; Notch-like_dom_sf.
DR InterPro; IPR022362; Notch_1.
DR InterPro; IPR024600; Notch_C.
DR InterPro; IPR000800; Notch_dom.
DR InterPro; IPR010660; Notch_NOD_dom.
DR InterPro; IPR011656; Notch_NODP_dom.
DR PANTHER; PTHR24044:SF514; ANTERIOR PHARYNX IN EXCESS PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR24044; NOTCH LIGAND FAMILY MEMBER; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF13637; Ank_4; 1.
DR Pfam; PF00008; EGF; 17.
DR Pfam; PF07645; EGF_CA; 3.
DR Pfam; PF12661; hEGF; 7.
DR Pfam; PF06816; NOD; 1.
DR Pfam; PF07684; NODP; 1.
DR Pfam; PF00066; Notch; 3.
DR PIRSF; PIRSF002279; Notch; 3.
DR PRINTS; PR01452; LNOTCHREPEAT.
DR PRINTS; PR01983; NOTCH.
DR PRINTS; PR01984; NOTCH1.
DR SMART; SM00248; ANK; 6.
DR SMART; SM01334; DUF3454; 1.
DR SMART; SM00181; EGF; 33.
DR SMART; SM00179; EGF_CA; 30.
DR SMART; SM00004; NL; 3.
DR SMART; SM01338; NOD; 1.
DR SMART; SM01339; NODP; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 18.
DR SUPFAM; SSF57184; Growth factor receptor domain; 4.
DR SUPFAM; SSF90193; Notch domain; 3.
DR PROSITE; PS50297; ANK_REP_REGION; 4.
DR PROSITE; PS50088; ANK_REPEAT; 4.
DR PROSITE; PS00010; ASX_HYDROXYL; 19.
DR PROSITE; PS00022; EGF_1; 30.
DR PROSITE; PS01186; EGF_2; 24.
DR PROSITE; PS50026; EGF_3; 33.
DR PROSITE; PS01187; EGF_CA; 9.
DR PROSITE; PS50258; LNR; 3.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Angiogenesis {ECO:0000256|ARBA:ARBA00022657};
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Calcium {ECO:0000256|PIRSR:PIRSR002279-1};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR002279-2};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR002279-1};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..2472
FT /note="Neurogenic locus notch homolog protein 1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5011977246"
FT DOMAIN 24..61
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 62..102
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 105..142
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 143..179
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 181..219
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 221..258
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 260..296
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 298..336
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 338..374
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 375..413
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 451..487
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 489..525
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 527..562
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 564..600
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 614..649
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 651..687
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 689..724
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 726..762
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 764..800
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 802..840
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 842..878
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 880..916
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 918..954
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 956..992
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 994..1030
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1032..1068
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1081..1116
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1118..1156
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1181..1225
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1227..1265
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1267..1306
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1308..1344
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1347..1386
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1409..1449
FT /note="LNR"
FT /evidence="ECO:0000259|PROSITE:PS50258"
FT DOMAIN 1450..1491
FT /note="LNR"
FT /evidence="ECO:0000259|PROSITE:PS50258"
FT DOMAIN 1492..1531
FT /note="LNR"
FT /evidence="ECO:0000259|PROSITE:PS50258"
FT REPEAT 1878..1910
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1945..1977
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1978..2010
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 2011..2043
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 1593..1616
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2105..2146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2294..2345
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2376..2472
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2121..2138
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2294..2308
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2309..2328
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2376..2423
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2431..2466
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 436
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT DISULFID 51..60
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 92..101
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 132..141
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 169..178
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 209..218
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 248..257
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 286..295
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 326..335
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 364..373
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 384..401
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 403..412
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 460..475
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 477..486
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2,
FT ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 515..524
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 531..541
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 552..561
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 618..628
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 639..648
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 677..686
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 693..703
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 714..723
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 752..761
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 790..799
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 811..828
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 830..839
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 868..877
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 906..915
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 944..953
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 982..991
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1020..1029
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1058..1067
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1106..1115
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1127..1144
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1215..1224
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1236..1253
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1255..1264
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1296..1305
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1334..1343
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1357..1374
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1376..1385
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2472 AA; 264718 MW; 18C0E2297B2A89FE CRC64;
MLRAPGAPCW CRLLLYADLS PAFPGLRCSQ PGTCENGGRC EVLNGTEACI CSGDFVGQRC
QDPNPCLSAP CKNAGTCHMV DQGGTVDYTC SCSLGFSGPL CLTPLDNACL SGPCRNGGTC
DLLTLTEYKC RCPPGWSGKS CQQADPCASN PCANGGHCLP FESTYICGCR PGFHGSTCRQ
DVNECSQTPG LCRNGGTCHN EVGSYRCACR PTHMGSNCEL PYVPCSPSPC QNGGTCRPTG
ETTHECACLP GFTGQNCEDN VDDCPGNSCR NGGACVDGVN TYNCRCPPEW TGQFCTEDVD
ECQLMPNACQ NGGTCHNTQG GYNCVCVNGW TGEDCSENID DCASAACFNG ATCHDRVASF
YCECPHGRTG LLCHLNDACI SNPCNEGSNC DTNPVNGKAI CTCPSGYTGP ACSQDVDECA
LGRFPCRAHA RDAGGSWWPG EARVPCAAPH WHLPTGANPC EHAGKCINTL GSFECQCLQG
YSGPRCEIDV NECISNPCQN DATCLDQIGE FQCICMPGYT GIHCEVDINE CDPDPCHYGS
CKDGVAAFTC LCQPGYTGHH CETNINECAS QPCRHGGTCQ DRDNAYLCLC LKGTTGVHLG
SRAGRYQRPN CEINLDDCAS SPCDAGTCLD KIDGYECACE PGYTGSMCNI NIDECAGSPC
HNGGTCEDGI NSFTCRCPEG YHDPTCLSEV NECSSNPCIH GSCQDSLNGY WCDCDSGWSG
TNCDINNNEC ESNPCVNGGT CRDMTSGYVC TCREGFSGPN CQTNINECAS NPCLNQGTCI
DDVAGYKCNC LLPYTGTTCE VVLAPCAPSP CKNSGVCRES EDYESFSCIC PSGWQGQTCE
VDINECVKSP CRHGASCQNT NGDYRCHCQA GYTGRDCETD VDDCRPNPCH NGGSCTDGVN
TAFCDCLPGF QGAFCEEDIN ECASSPCRNG ANCTDCVDSY TCTCPAGFNG IHCENNTPDC
TESSCFNGGT CVDGINSFTC LCPPGFTGSY CQHDINECDS RPCLNGGTCQ DSYGTYKCTC
PQGYTGLNCQ NLVRWCDSSP CKNGGQCWQT STLYRCECHS GWTGLYCDVP SVSCKVAAQQ
RDIDVAYLCQ HGGLCVDAGN THHCRCQAGY TGSYCEEEVD ECSPSPCQNG ATCTDYLGGY
SCKCSCPRGT QGEPPLPADM GQRKPHVPDR GSPVGVHCEI NVDDCSPLHD LASRSPKCFN
NGTCVDQVGG YTCTCPPGFV GERCEGDVNE CLSNPCDARG TQNCVQRVND FHCECRAGHT
GRRCESVIDG CKGKPCRNGG VCAVATNTAR GFICRCPAGF EGATCENDAR TCGSLRCLNG
GTCISGPRSP TCLCLGAFTG PECQFPASSP CMGDNPCYNQ GTCEPTAESP FYRCLCPAKF
NGLQCHILDY SFVGGAGRDI PPPEVEEACE LPECQEDAGN KVCSLQCNNH ACGWDGGDCS
LNFNDPWKNC SQSLQCWKYF SDGRCDSQCN SAGCLFDGFD CQHAEGQCNP LYDQYCKDHF
SDGHCDQGCN SAECEWDGLD CAEHVPERLA AGTLVVVVLL PPEQLRNNSF HFLRELSRVL
HTNVVFKRDA QGQQMIFPYY GREEELRKHP IKRSAPGWAT PGSLLGQAGP GRQRRELDPM
DIRGSIVYLE IDNRQCVQLS SQCFQSATDV AAFLGALASL GSLNIPYKIE AVQSETVEPP
PPSQLHLMYL IGAAFVLLFF VGCGVLLSRK RRRQHGQLWF PEGFKVSEAS KKKRREPLGE
DSVGLKPLKN VSDGALMDDN QNEWGDEDLE AKKFRFEEPV VLPDLDDQTD HRQWTQQHLD
AADLRVSAMA PTPPQGEVDA DCMDVNVRGP DGFTPLMIAS CSGGGLETGN SEEEEDAPAV
ISDFIYQGAS LHNQTDRTGE TALHLAARYS RSDAAKRLLE ASADANIQDN MGRTPLHAAV
SADAQGVFQI LIRNRATDLD ARMHDGTTPL ILAARLAVEG MLEDLINSHA DVNAVDDLGK
SALHWAAAVN NVDAALVLLK NGANKDMQNN KEETPLFLAA REGSYETAKV LLDHFANRDI
TDHMDRLPRD IAQERMHHDI VRLLDEYNLV RSPQLHNAAL GSTPTLSPTL CSPNGYLGNL
KPAMQGKKAR KPSTKGLACG SKEAKDLKAR RKKSQDGKGC LLDSSSMLSP VDSLESPHGY
LSDVASPPLL PSPFQPSPSL PLSHLPGMPD AHLGINHLNV TAKPEMAPGP PRLSHLPVAS
STSTVLGASS SGAVNFTVGT AAGLNGQCDW LSRLQNGMVS GQYNPLRGAV APGTLSTQGL
PSTRLATQPH LVQAQQVPQV QQQNLQVQPP NLQPPPNIQQ PQSLQPQLPP SQPHLGVGSV
ANGHLGRSFM GGEPSQADVQ PLGPNSLTVH TILPQEGQNL PTSMPSSLVP PMTTAQFLTP
PSQHSYSSSP VDNTPSHQLQ VPEHPFLTPS PESPDQWSSS SPHSNISDWS EGISSPPTSM
QSQITHIPEA FK
//
