ID H0VNG9_CAVPO Unreviewed; 860 AA.
AC H0VNG9;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=A-kinase anchoring protein 1 {ECO:0000313|Ensembl:ENSCPOP00000011998.3};
GN Name=AKAP1 {ECO:0000313|Ensembl:ENSCPOP00000011998.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000011998.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000011998.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000011998.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAKN02042255; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003466871.1; XM_003466823.3.
DR AlphaFoldDB; H0VNG9; -.
DR STRING; 10141.ENSCPOP00000011998; -.
DR Ensembl; ENSCPOT00000013457.3; ENSCPOP00000011998.3; ENSCPOG00000013327.4.
DR GeneID; 100723081; -.
DR KEGG; cpoc:100723081; -.
DR CTD; 8165; -.
DR VEuPathDB; HostDB:ENSCPOG00000013327; -.
DR eggNOG; KOG2279; Eukaryota.
DR GeneTree; ENSGT00390000001360; -.
DR HOGENOM; CLU_016731_0_0_1; -.
DR InParanoid; H0VNG9; -.
DR OMA; CLTNIYT; -.
DR OrthoDB; 4118571at2759; -.
DR TreeFam; TF105401; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000013327; Expressed in testis and 13 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR GO; GO:0034237; F:protein kinase A regulatory subunit binding; IEA:Ensembl.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140374; P:antiviral innate immune response; IEA:Ensembl.
DR GO; GO:0006915; P:apoptotic process; IEA:Ensembl.
DR CDD; cd22395; KH-I_AKAP1; 1.
DR CDD; cd20407; Tudor_AKAP1; 1.
DR Gene3D; 2.30.30.140; -; 1.
DR Gene3D; 2.40.50.90; -; 1.
DR Gene3D; 3.30.1370.10; K Homology domain, type 1; 1.
DR InterPro; IPR047368; KH-I_AKAP1.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR004088; KH_dom_type_1.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR InterPro; IPR018459; RII-bd_1.
DR InterPro; IPR035437; SNase_OB-fold_sf.
DR InterPro; IPR002999; Tudor.
DR InterPro; IPR047367; Tudor_AKAP1.
DR PANTHER; PTHR22948:SF65; A-KINASE ANCHOR PROTEIN 1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR22948; TUDOR DOMAIN CONTAINING PROTEIN; 1.
DR Pfam; PF00013; KH_1; 1.
DR Pfam; PF10522; RII_binding_1; 1.
DR Pfam; PF00567; TUDOR; 1.
DR SMART; SM00322; KH; 1.
DR SMART; SM00333; TUDOR; 1.
DR SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 1.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 1.
DR PROSITE; PS50084; KH_TYPE_1; 1.
DR PROSITE; PS50304; TUDOR; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00117};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..26
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 715..774
FT /note="Tudor"
FT /evidence="ECO:0000259|PROSITE:PS50304"
FT REGION 74..128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 170..199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 275..299
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 366..435
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 456..555
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 104..126
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 179..193
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 456..505
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 860 AA; 92349 MW; E873FC5A947D5A56 CRC64;
MAVQFRSLFP LALPGMLALL GWWWFFSRKK QQVSSNKEQA ESGAVALSAG PTTKEPLPTE
EACSTVVSVP LSVTQLPRNK ESAPSKPSTE PPAPLWMHLP HHRSESSGSL QNTTDVRSQP
GTRKDNTTKV ELAVMGDKAK PVPLGCPLTF PKDLLFSQEA AEVCKQEPTL SGMPTTEKRG
AGEKAREREM GGTEGNGDAV LGETVLAKGL LPQERALDPE NGKAFGLAPS GGKIAKGSGS
LPLVVGPVRA LPKEEYPLGK LPGVLVQSAK EEATQTPWVT SGNARDKDPV GELGKEEALD
ENEKLEQAAF QIISQVILEA TEEVLATTDQ AAANQPQGRK EEENCAPVSQ ETLMGRDIIE
PTLATAGAAA SSQDTALPSP GPLAADLPPP KTYVSCLSSP LSSPTKDRKP KNSAHPISLA
PCPAPDTPLR ESLDQASSLA GDATCVTCML DKSQSVSPVT TSGQCSDSVS MSGLGDSCTE
TNSSPKDNNR TPPLPASTQP FSNGVLKGEL SDVGTEDGWS VDAEADHSGG SDANSMDSEN
CWERRKTDDL QNAQAGSNPK KVDLIIWEIE VPKHLVGRLI GKQGRYVSFL KQTSGAKIYI
STLPYTQNIQ ICHIEGSQHH VDKALNLIGK KFKELNLTNI YAPPLPSLAL PSLPMTSWLM
LPDGITVEVI VVNQVNAGHL FVQQHTHPTF HALRSLDQQM YLCYSQPGIP TLPTPVKIMV
ICAAPGVDGA WWRAQVVASY EETNEVEIRY VDYGGYKRVK VDVLRQIRSD FVTLPFQGAE
VLLDSVMPLS DDDHFSPEAD AAMSEMTGNT ALLAQVTSYS PTGLPLIQLW SVVGDEVVLI
NRSLVERGLA QWVDSYYLSL
//
