ID H0VNP3_CAVPO Unreviewed; 2484 AA.
AC H0VNP3;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 24-JAN-2024, entry version 72.
DE SubName: Full=Ankyrin repeat domain 17 {ECO:0000313|Ensembl:ENSCPOP00000012078.3};
GN Name=ANKRD17 {ECO:0000313|Ensembl:ENSCPOP00000012078.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000012078.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000012078.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000012078.3};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
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DR EMBL; AAKN02040166; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02040167; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02040168; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02040169; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02040170; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02040171; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 10141.ENSCPOP00000012078; -.
DR Ensembl; ENSCPOT00000013547.3; ENSCPOP00000012078.3; ENSCPOG00000013416.4.
DR VEuPathDB; HostDB:ENSCPOG00000013416; -.
DR eggNOG; KOG0504; Eukaryota.
DR eggNOG; KOG4369; Eukaryota.
DR GeneTree; ENSGT00940000153768; -.
DR HOGENOM; CLU_000590_0_1_1; -.
DR InParanoid; H0VNP3; -.
DR OMA; FGANIDH; -.
DR TreeFam; TF328552; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000013416; Expressed in heart left ventricle and 12 other cell types or tissues.
DR GO; GO:0000785; C:chromatin; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0001673; C:male germ cell nucleus; IEA:Ensembl.
DR GO; GO:0031965; C:nuclear membrane; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0001955; P:blood vessel maturation; IEA:Ensembl.
DR GO; GO:0042742; P:defense response to bacterium; IEA:Ensembl.
DR GO; GO:0045087; P:innate immune response; IEA:Ensembl.
DR GO; GO:0051151; P:negative regulation of smooth muscle cell differentiation; IEA:Ensembl.
DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:1900087; P:positive regulation of G1/S transition of mitotic cell cycle; IEA:Ensembl.
DR GO; GO:1900245; P:positive regulation of MDA-5 signaling pathway; IEA:Ensembl.
DR GO; GO:1900246; P:positive regulation of RIG-I signaling pathway; IEA:Ensembl.
DR GO; GO:0006275; P:regulation of DNA replication; IEA:Ensembl.
DR CDD; cd22502; KH-I_ANKRD17; 1.
DR CDD; cd22249; UDM1_RNF168_RNF169-like; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 9.
DR Gene3D; 3.30.1370.10; K Homology domain, type 1; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR047375; KH-I_ANKRD17.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR004088; KH_dom_type_1.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR PANTHER; PTHR23206:SF1; ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 17; 1.
DR PANTHER; PTHR23206; MASK PROTEIN; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 8.
DR Pfam; PF13637; Ank_4; 1.
DR Pfam; PF00013; KH_1; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 25.
DR SMART; SM00322; KH; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 3.
DR SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 1.
DR PROSITE; PS50297; ANK_REP_REGION; 20.
DR PROSITE; PS50088; ANK_REPEAT; 20.
DR PROSITE; PS50084; KH_TYPE_1; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00117}.
FT REPEAT 208..240
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 241..273
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 274..306
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 308..340
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 341..373
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 374..406
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 407..439
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 471..503
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 504..536
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 537..569
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 571..603
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 991..1023
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1024..1056
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1058..1090
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1091..1123
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1126..1158
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1160..1192
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1193..1225
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1228..1260
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1261..1293
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 1633..1703
FT /note="K Homology"
FT /evidence="ECO:0000259|SMART:SM00322"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 943..968
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1388..1409
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1427..1448
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1464..1546
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1586..1626
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1815..1904
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1920..2054
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2068..2102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2144..2201
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2268..2328
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 716..812
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 9..23
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 943..964
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1505..1546
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1586..1616
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1853..1904
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1920..1938
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1960..2022
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2144..2183
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2314..2328
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2484 AA; 262876 MW; 811BF86AFD8AFD07 CRC64;
KRHRTCRPPS SSESSSDSSI HSVGAAVSLL EEQEEEVFEV ESFILDQDDL ENPMLETASK
LLLSGTADGA DLRTVDPETQ ARLEALLEAA GIGKLSTADG KAFADPEVLR RLTSSVSCAL
DEAAAALTRM RAESTANAGQ SDNRSLAEAC SEGDVNAVRK LLIEGRSVNE HTEEGESLLC
LACSAGYYEL AQVLLAMHAN VEDRGIKGDI TPLMAAANGG HVKIVKLLLA HKADVNAQSS
TGNTALTYAC AGGYVDVVKV LLESGASIED HNENGHTPLM EAGSAGHVEV ARLLLENGAG
INTHSNEFKE SALTLACYKG HLEMVRFLLE AGADQEHKTD EMHTALMEAC MDGHVEVARL
LLDSGAQVNM PADSFESPLT LAACGGHVEL AALLIERGAS LEEVNDEGYT PLMEAAREGH
EEMVALLLGQ GANINAQTEE TQETALTLAC CGGFLEVADF LIKAGADIEL GCSTPLMEAA
QEGHLELVKY LLAAGANVHA TTATGDTALT YACENGHTDV ADVLLQAGAD LEHESEGGRT
PLMKAARAGH VCTVQFLISK GANVNRTTAN NDHTVLSLAC AGGHLAVVEL LLAHGADPTH
RLKDGSTMLI EAAKGGHTSV VCYLLDYPNN LLSAPPPDVT QLTPPSHDLN RAPRVPVQAL
PMVVPPQEPD KPPANIATTL PIRNKAASKQ KSSSHLPANS QDVQGYITNQ SPESIVEEAQ
GKLTELEQRI KEAIEKNAQL QSLELAHADQ LTKEKIEELN KTREEQIQKK QKILEELQKV
ERELQLKTQQ QLKKQYLEVK AQRIQLQQQQ QQQSCQHLGL LTPVGVEEHL SEGDYARLQQ
VDPVLLKDEP QQTAAQIGFA PIQPLAMPQA LPLAAGPLPP GSIANLTELQ GVIVGQPVLG
QAQLAGLGQG ILTETQQGLM VASPAQTLND TLDDIMAAVS GRASAMSNTP PHSAAASMSQ
PQTPAPSPVI SPSAMLPIYP AIDIDAQTES NHDTALTLAC AGGHEELVQT LLERGASIEH
RDKKGFTPLI LAATAGHVGV VEILLDNGAD IEAQSERTKD TPLSLACSGG RQEVVELLLA
RGANKEHRNV SDYTPLSLAA SGGYVNIIKI LLNAGAEINS RTGSKLGISP LMLAAMNGHT
AAVKLLLDMG SDINAQIETN RNTALTLACF QGRTEVVSLL LDRKANVEHR AKTGLTPLME
AASGGYAEVG RVLLDKGADV NAPPVPSSRD TALTIAADKG HYKFCELLIG RGAHIDVRNK
KGNTPLWLAA NGGHLDVVQL LVQAGADVDA ADNRKITPLM AAFRKGHVKV VRYLVKEVNQ
FPSDSECMRY IATITDKEML KKCHLCMESI VQAKDRQAAE ANKNASILLE ELDLEKLREE
SRRLALAAKR EKRKEKRRKK KEEQRRKLEE IEAKNKENFE LQAAQEKEKL KAEEEPEVLT
EPPSATTTTT IGISATWTTL AGAHGKRNNT ITTTTSKRKN RKNKITTENV QIIFDDPLPI
SYSQPEKVNG ESKSSSTSES GDSDNMRISS CSDESSNSNS SLKSDNHSAA VAATTVTSKK
QPSVLVTFPK EERKSISGKA SVKLSETFNE GTSSSLSTCT KSGPSPLSSP NGKLTVASPK
RGQKREEGWK EVVRRSKKVS VPSTVISRVI GRGGCNINAI REFTGAHIDI DKQKDKTGDR
IITIRGGTES TRQATQLINA LIKDPDKEID ELIPKSRLKS SSANSKIGSS APVTTAANSS
LMGIKMTTVA LSSTSQTATA LTVPAISSAS THKTIKNPVN NVRPGFPVSL PLAYPPPQFA
HALLAAQTFQ QIRPPRLPMT HFGGTFPPAQ STWGPFPVRP LSPARATNSP KPHMVPRHSN
QNSSGSQVNS AGSLTSSPTT TTSSSASTVP GTSTNGSPSS PSVRRQLFVT VVKTSNATTT
TVTTTASNNS TAPTNATYPM PTAKEHYPVS SPSSPSPPAQ PGGISRNSPL ECGSVSPNKG
ASSSEQEAGS PPVVETANSR PPNSSSSGSS SVHSAQQQPP GSVSQEPRPP LPQSQVPPLE
VRMTVPPLAT TSSAPVVVPS TAPVTYPVPQ TQMGCPQPPK VETPAARPPS HGTAAPLKNP
APVQNSSVAV LNVNHIKRPH SVPSSVQLPS TLSTQSACQN SVHPANKPLA PNFRSVVSSQ
STPESMLSGK SSYLPNADPL HQSDTSKAPG FRPPLQRPIP SPSGIVNMDS PYGSVTPSTH
LGNFASNLSG GQMYGPVAPL GGAPTAANFN RQHFSPLSLL TPCSSASNSA AQSVSSGVRA
PSPAPPSVPL GSEKPSSISQ DRKVPVPIGT ERSARIRQTG TSAPSVIGSN LSTSVGHSGI
WSFEGIGGSQ DKVDWCNPGM GNPMIHRPMS DPGVFSQHQA MERDSTGIVT PSGTFHQHVP
AGYMDFPKVG GMPFSVYGNA MIPPVAPIPD GPGGPIFNGP HAADPSWNSL IKMVSSSTEN
NGPQTVWTGP WAPHMNSVHM NQLG
//