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Database: UniProt
Entry: H0VNP3_CAVPO
LinkDB: H0VNP3_CAVPO
Original site: H0VNP3_CAVPO 
ID   H0VNP3_CAVPO            Unreviewed;      2484 AA.
AC   H0VNP3;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 2.
DT   24-JAN-2024, entry version 72.
DE   SubName: Full=Ankyrin repeat domain 17 {ECO:0000313|Ensembl:ENSCPOP00000012078.3};
GN   Name=ANKRD17 {ECO:0000313|Ensembl:ENSCPOP00000012078.3};
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC   Cavia.
OX   NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000012078.3, ECO:0000313|Proteomes:UP000005447};
RN   [1] {ECO:0000313|Proteomes:UP000005447}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA   Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA   Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA   Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA   Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA   Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA   Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA   Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA   Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA   Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA   Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA   Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA   Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA   Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA   Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSCPOP00000012078.3}
RP   IDENTIFICATION.
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000012078.3};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
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DR   EMBL; AAKN02040166; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02040167; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02040168; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02040169; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02040170; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02040171; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 10141.ENSCPOP00000012078; -.
DR   Ensembl; ENSCPOT00000013547.3; ENSCPOP00000012078.3; ENSCPOG00000013416.4.
DR   VEuPathDB; HostDB:ENSCPOG00000013416; -.
DR   eggNOG; KOG0504; Eukaryota.
DR   eggNOG; KOG4369; Eukaryota.
DR   GeneTree; ENSGT00940000153768; -.
DR   HOGENOM; CLU_000590_0_1_1; -.
DR   InParanoid; H0VNP3; -.
DR   OMA; FGANIDH; -.
DR   TreeFam; TF328552; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   Bgee; ENSCPOG00000013416; Expressed in heart left ventricle and 12 other cell types or tissues.
DR   GO; GO:0000785; C:chromatin; IEA:Ensembl.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0001673; C:male germ cell nucleus; IEA:Ensembl.
DR   GO; GO:0031965; C:nuclear membrane; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0001955; P:blood vessel maturation; IEA:Ensembl.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:Ensembl.
DR   GO; GO:0045087; P:innate immune response; IEA:Ensembl.
DR   GO; GO:0051151; P:negative regulation of smooth muscle cell differentiation; IEA:Ensembl.
DR   GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IEA:Ensembl.
DR   GO; GO:1900087; P:positive regulation of G1/S transition of mitotic cell cycle; IEA:Ensembl.
DR   GO; GO:1900245; P:positive regulation of MDA-5 signaling pathway; IEA:Ensembl.
DR   GO; GO:1900246; P:positive regulation of RIG-I signaling pathway; IEA:Ensembl.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:Ensembl.
DR   CDD; cd22502; KH-I_ANKRD17; 1.
DR   CDD; cd22249; UDM1_RNF168_RNF169-like; 1.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 9.
DR   Gene3D; 3.30.1370.10; K Homology domain, type 1; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR047375; KH-I_ANKRD17.
DR   InterPro; IPR004087; KH_dom.
DR   InterPro; IPR004088; KH_dom_type_1.
DR   InterPro; IPR036612; KH_dom_type_1_sf.
DR   PANTHER; PTHR23206:SF1; ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 17; 1.
DR   PANTHER; PTHR23206; MASK PROTEIN; 1.
DR   Pfam; PF00023; Ank; 1.
DR   Pfam; PF12796; Ank_2; 8.
DR   Pfam; PF13637; Ank_4; 1.
DR   Pfam; PF00013; KH_1; 1.
DR   PRINTS; PR01415; ANKYRIN.
DR   SMART; SM00248; ANK; 25.
DR   SMART; SM00322; KH; 1.
DR   SUPFAM; SSF48403; Ankyrin repeat; 3.
DR   SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 20.
DR   PROSITE; PS50088; ANK_REPEAT; 20.
DR   PROSITE; PS50084; KH_TYPE_1; 1.
PE   4: Predicted;
KW   ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW   ProRule:PRU00023};
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00117}.
FT   REPEAT          208..240
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          241..273
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          274..306
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          308..340
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          341..373
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          374..406
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          407..439
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          471..503
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          504..536
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          537..569
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          571..603
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          991..1023
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          1024..1056
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          1058..1090
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          1091..1123
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          1126..1158
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          1160..1192
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          1193..1225
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          1228..1260
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          1261..1293
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   DOMAIN          1633..1703
FT                   /note="K Homology"
FT                   /evidence="ECO:0000259|SMART:SM00322"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          943..968
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1388..1409
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1427..1448
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1464..1546
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1586..1626
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1815..1904
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1920..2054
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2068..2102
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2144..2201
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2268..2328
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          716..812
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        9..23
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        943..964
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1505..1546
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1586..1616
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1853..1904
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1920..1938
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1960..2022
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2144..2183
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2314..2328
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2484 AA;  262876 MW;  811BF86AFD8AFD07 CRC64;
     KRHRTCRPPS SSESSSDSSI HSVGAAVSLL EEQEEEVFEV ESFILDQDDL ENPMLETASK
     LLLSGTADGA DLRTVDPETQ ARLEALLEAA GIGKLSTADG KAFADPEVLR RLTSSVSCAL
     DEAAAALTRM RAESTANAGQ SDNRSLAEAC SEGDVNAVRK LLIEGRSVNE HTEEGESLLC
     LACSAGYYEL AQVLLAMHAN VEDRGIKGDI TPLMAAANGG HVKIVKLLLA HKADVNAQSS
     TGNTALTYAC AGGYVDVVKV LLESGASIED HNENGHTPLM EAGSAGHVEV ARLLLENGAG
     INTHSNEFKE SALTLACYKG HLEMVRFLLE AGADQEHKTD EMHTALMEAC MDGHVEVARL
     LLDSGAQVNM PADSFESPLT LAACGGHVEL AALLIERGAS LEEVNDEGYT PLMEAAREGH
     EEMVALLLGQ GANINAQTEE TQETALTLAC CGGFLEVADF LIKAGADIEL GCSTPLMEAA
     QEGHLELVKY LLAAGANVHA TTATGDTALT YACENGHTDV ADVLLQAGAD LEHESEGGRT
     PLMKAARAGH VCTVQFLISK GANVNRTTAN NDHTVLSLAC AGGHLAVVEL LLAHGADPTH
     RLKDGSTMLI EAAKGGHTSV VCYLLDYPNN LLSAPPPDVT QLTPPSHDLN RAPRVPVQAL
     PMVVPPQEPD KPPANIATTL PIRNKAASKQ KSSSHLPANS QDVQGYITNQ SPESIVEEAQ
     GKLTELEQRI KEAIEKNAQL QSLELAHADQ LTKEKIEELN KTREEQIQKK QKILEELQKV
     ERELQLKTQQ QLKKQYLEVK AQRIQLQQQQ QQQSCQHLGL LTPVGVEEHL SEGDYARLQQ
     VDPVLLKDEP QQTAAQIGFA PIQPLAMPQA LPLAAGPLPP GSIANLTELQ GVIVGQPVLG
     QAQLAGLGQG ILTETQQGLM VASPAQTLND TLDDIMAAVS GRASAMSNTP PHSAAASMSQ
     PQTPAPSPVI SPSAMLPIYP AIDIDAQTES NHDTALTLAC AGGHEELVQT LLERGASIEH
     RDKKGFTPLI LAATAGHVGV VEILLDNGAD IEAQSERTKD TPLSLACSGG RQEVVELLLA
     RGANKEHRNV SDYTPLSLAA SGGYVNIIKI LLNAGAEINS RTGSKLGISP LMLAAMNGHT
     AAVKLLLDMG SDINAQIETN RNTALTLACF QGRTEVVSLL LDRKANVEHR AKTGLTPLME
     AASGGYAEVG RVLLDKGADV NAPPVPSSRD TALTIAADKG HYKFCELLIG RGAHIDVRNK
     KGNTPLWLAA NGGHLDVVQL LVQAGADVDA ADNRKITPLM AAFRKGHVKV VRYLVKEVNQ
     FPSDSECMRY IATITDKEML KKCHLCMESI VQAKDRQAAE ANKNASILLE ELDLEKLREE
     SRRLALAAKR EKRKEKRRKK KEEQRRKLEE IEAKNKENFE LQAAQEKEKL KAEEEPEVLT
     EPPSATTTTT IGISATWTTL AGAHGKRNNT ITTTTSKRKN RKNKITTENV QIIFDDPLPI
     SYSQPEKVNG ESKSSSTSES GDSDNMRISS CSDESSNSNS SLKSDNHSAA VAATTVTSKK
     QPSVLVTFPK EERKSISGKA SVKLSETFNE GTSSSLSTCT KSGPSPLSSP NGKLTVASPK
     RGQKREEGWK EVVRRSKKVS VPSTVISRVI GRGGCNINAI REFTGAHIDI DKQKDKTGDR
     IITIRGGTES TRQATQLINA LIKDPDKEID ELIPKSRLKS SSANSKIGSS APVTTAANSS
     LMGIKMTTVA LSSTSQTATA LTVPAISSAS THKTIKNPVN NVRPGFPVSL PLAYPPPQFA
     HALLAAQTFQ QIRPPRLPMT HFGGTFPPAQ STWGPFPVRP LSPARATNSP KPHMVPRHSN
     QNSSGSQVNS AGSLTSSPTT TTSSSASTVP GTSTNGSPSS PSVRRQLFVT VVKTSNATTT
     TVTTTASNNS TAPTNATYPM PTAKEHYPVS SPSSPSPPAQ PGGISRNSPL ECGSVSPNKG
     ASSSEQEAGS PPVVETANSR PPNSSSSGSS SVHSAQQQPP GSVSQEPRPP LPQSQVPPLE
     VRMTVPPLAT TSSAPVVVPS TAPVTYPVPQ TQMGCPQPPK VETPAARPPS HGTAAPLKNP
     APVQNSSVAV LNVNHIKRPH SVPSSVQLPS TLSTQSACQN SVHPANKPLA PNFRSVVSSQ
     STPESMLSGK SSYLPNADPL HQSDTSKAPG FRPPLQRPIP SPSGIVNMDS PYGSVTPSTH
     LGNFASNLSG GQMYGPVAPL GGAPTAANFN RQHFSPLSLL TPCSSASNSA AQSVSSGVRA
     PSPAPPSVPL GSEKPSSISQ DRKVPVPIGT ERSARIRQTG TSAPSVIGSN LSTSVGHSGI
     WSFEGIGGSQ DKVDWCNPGM GNPMIHRPMS DPGVFSQHQA MERDSTGIVT PSGTFHQHVP
     AGYMDFPKVG GMPFSVYGNA MIPPVAPIPD GPGGPIFNGP HAADPSWNSL IKMVSSSTEN
     NGPQTVWTGP WAPHMNSVHM NQLG
//
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