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Database: UniProt
Entry: H0VPZ0_CAVPO
LinkDB: H0VPZ0_CAVPO
Original site: H0VPZ0_CAVPO 
ID   H0VPZ0_CAVPO            Unreviewed;      1943 AA.
AC   H0VPZ0;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 2.
DT   22-NOV-2017, entry version 45.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN10A {ECO:0000313|Ensembl:ENSCPOP00000012586};
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricomorpha; Caviidae; Cavia.
OX   NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000012586};
RN   [1] {ECO:0000313|Ensembl:ENSCPOP00000012586}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000012586};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSCPOP00000012586}
RP   IDENTIFICATION.
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000012586};
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCPOP00000012586}.
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DR   EMBL; AAKN02049254; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02049255; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02049256; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02049257; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSCPOT00000014109; ENSCPOP00000012586; ENSCPOG00000013968.
DR   GeneTree; ENSGT00830000128242; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0044325; F:ion channel binding; IEA:Ensembl.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:Ensembl.
DR   GO; GO:0086016; P:AV node cell action potential; IEA:Ensembl.
DR   GO; GO:0086043; P:bundle of His cell action potential; IEA:Ensembl.
DR   GO; GO:0060371; P:regulation of atrial cardiac muscle cell membrane depolarization; IEA:Ensembl.
DR   GO; GO:0055117; P:regulation of cardiac muscle contraction; IEA:Ensembl.
DR   GO; GO:0002027; P:regulation of heart rate; IEA:Ensembl.
DR   GO; GO:0019233; P:sensory perception of pain; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028809; Na_channel_a10su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   PANTHER; PTHR10037:SF208; PTHR10037:SF208; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005447};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
SQ   SEQUENCE   1943 AA;  218874 MW;  B8061E21C963EB33 CRC64;
     MELPFGFLET TNFRRFTPES LAEIEKQIAA LKAGKKVRDK HREQKDQKEK PRPQLDLKAC
     NQLPKFYGEL PAELIGEPLE DLDPFYKAHR TFMVLNKGRT ISRFSATRAL WLFSPFNLIR
     RTAIKVSVHS WFTLFITLTI VANCVCMTRS DLPEKIEYLF TVIYTFEALI KILARGFCLN
     EFTYLRDPWN WLDFSVITLA YVGTATDLKG FSGLRTFRVL RALKTVSVIP GLKVIVGALI
     HSVRKLADVT ILTVFCLSVF ALVGLQLFKG NLKNKCVRNG TTPQQAANCS SADYTYAIKP
     GTLDPLLCGN GTGAGLCPDG YICLKTCENP DFNYTSFDSF AWAFLSLFRL MTQDSWERLY
     QQTLRASGKM YMVFFVIVIF LGSFYLVNLI LAVVTMAYEE QNQATIAEIE AKEKTFQEAL
     ERRRKEQEVL LAMGIDTASL PSRNGSPLGS KNTSERRHRM KSRASEGSTE DNKSPQSEQY
     NQRRMSFLGL TSGRRRASHG NAFHFRAPGQ DVSFPDGIAD DGVFHGDHES RQGSLLLGRG
     AGQQGSLPRS PLPQPPNPGS RHEEEGHPTL PAIELPPGAT EVLAFDAGQK KIFLSADYLN
     EPFRAQRAMS VVSIMTSVIE ELEESERKCP PCLTSLAQKY LIWECCPTWL KLKEVLFKLV
     TDPFAELTIT LCIVVNTIFM AMEHHGMSSA FESMLQIGNI VFTIFFTAEM VFKIIAFDPY
     YYFQKKWNIF DCVIVTVSLL ELSMVKKGSL SVLRTFRLLR VFKLAKSWPT LNTLIKIIGN
     SVGALGNLTI ILAIIVFIFA LVGKQLLGEA YCTKGNILPG DEPPRWHMHD FFHSFLIVFR
     ILCGEWIENM WACMQVSEKP LCLILFLTVM VLGNLVVLNL FIALLLNSFS ADNLTTPDDD
     GEVNKLQVAL GRLQVFGRQT RRALRGFFCR LCLLAGPKVE SQLTEKPPLS SSKAENHIAA
     SGSPRAPPPP RGPSAEHNDF ITNPNLWVSV PIAEGESDLD DSEDGEQDAP NSWPGTLEGL
     LPQAERCGDH LTPRSPCSGT SSEDLAPFQA SEGEEWVRAG SRPWASVLQV MDDTSSSEGS
     TVDCPDPEEI LRKIPELADD LQEPDDCFTE GCLRYCPCCN VNITKLPWAM GWQLRKTCYR
     IVEHSWFESF IIFMILLSSG SLAFEDCYLD QKPTVKALLE YTDRVFTFIF VFEMLLKWVA
     YGFKKYFTNA WCWLDFLIVN ISLVSLTAKI LEYSDVESIK ALRTLRALRP LRALSRFEGM
     RVVVDALLGA IPSIMNVLLV CLIFWLIFSI MGVNLFAGKF GRCINQTNGD FALVNWTVVN
     NMSECENQNY TGHLFWVNVK VNFDNVMMGY LALLQVATFK GWMDIMYAAV DSREVNSQPK
     WEDNVYMYLY FVIFIIFGGF FTLNLFVGVI IDNFNQQKKK IRGQDIFMTE EQKKYYNAMK
     KLGSKKPQKP IPRPLNKYQG FVFDIVTKQA FDISIMVLIC LNMITMMVET DDQSKEKTQV
     LGKINQFFVA VFTGECVLKM FALRHYYFTN GWNVFDLIVV LLSISSLIFS AILTSIESYF
     SPTLFRVIRL ARIGRILRLI RAAKGIRTLL FALMMSLPAL FNIGLLLFLV MFIYSIFGMS
     SFPHVKEEAG IDDMFNFKTF ANSMLCLFQI TTSAGWDALL SPILNTGPPY CNGTRGDCGS
     PAVGIFFFTT YIIISFLIVV NMYIAVILEN FNAATEESTE PLSEDDFDMF YETWEKFDPE
     ATQFITFSAL SDFADTLSGP LRIPKPNRNI LIQMDLPLVP GDKIHCLDIL FAFTKKVLGE
     SGELDTLKAS MEEKFMATNL SKTSYEPIAT TLRWKQEDIS ATVIQKAYRS YVQHRSLACS
     NSSGVPRAEE EAESLPGEGF VAFMANENYA LPDKSETASA TSFPPSYDSV TRGLNDRITM
     STSSSIQNED EAMSKAVTDP GPQ
//
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