GenomeNet

Database: UniProt
Entry: H0VPZ0_CAVPO
LinkDB: H0VPZ0_CAVPO
Original site: H0VPZ0_CAVPO 
ID   H0VPZ0_CAVPO            Unreviewed;      1942 AA.
AC   H0VPZ0;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   27-SEP-2017, entry version 43.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN10A {ECO:0000313|Ensembl:ENSCPOP00000012586};
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricomorpha; Caviidae; Cavia.
OX   NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000012586};
RN   [1] {ECO:0000313|Ensembl:ENSCPOP00000012586}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000012586};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSCPOP00000012586}
RP   IDENTIFICATION.
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000012586};
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCPOP00000012586}.
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DR   EMBL; AAKN02049254; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02049255; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02049256; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02049257; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSCPOT00000014109; ENSCPOP00000012586; ENSCPOG00000013968.
DR   GeneTree; ENSGT00830000128242; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0044325; F:ion channel binding; IEA:Ensembl.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:Ensembl.
DR   GO; GO:0086016; P:AV node cell action potential; IEA:Ensembl.
DR   GO; GO:0086043; P:bundle of His cell action potential; IEA:Ensembl.
DR   GO; GO:0060371; P:regulation of atrial cardiac muscle cell membrane depolarization; IEA:Ensembl.
DR   GO; GO:0055117; P:regulation of cardiac muscle contraction; IEA:Ensembl.
DR   GO; GO:0002027; P:regulation of heart rate; IEA:Ensembl.
DR   GO; GO:0019233; P:sensory perception of pain; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028809; Na_channel_a10su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   PANTHER; PTHR10037:SF263; PTHR10037:SF263; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005447};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    128    146       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    158    177       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    189    210       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    222    243       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    249    268       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    371    398       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    694    715       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    782    802       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    863    886       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1145   1163       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1184   1200       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1212   1231       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1276   1296       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1349   1367       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1387   1410       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1533   1552       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1588   1616       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1684   1707       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      129    404       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      664    890       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      900   1139       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1143   1418       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1468   1717       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      406    429       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1942 AA;  218697 MW;  8D6A02FCBF744332 CRC64;
     MELPFGFLET TNFRRFTPES LAEIEKQIAA LKAGKKVRDK HREQKDQKEK PRPQLDLKAC
     NQLPKFYGEL PAELIGEPLE DLDPFYKAHR TFMVLNKGRT ISRFSATRAL WLFSPFNLIR
     RTAIKVSVHS WFTLFITLTI VANCVCMTRS DLPEKIEYLF TVIYTFEALI KILARGFCLN
     EFTYLRDPWN WLDFSVITLA YVGTATDLKG FSGLRTFRVL RALKTVSVIP GLKVIVGALI
     HSVRKLADVT ILTVFCLSVF ALVGLQLFKG NLKNKCVRNG TTPQQAANCS SADYTYAIKP
     GTLDPLLCGN GTGAGLCPDG YICLKTCENP DFNYTSFDSF AWAFLSLFRL MTQDSWERLY
     QQTLRASGKM YMVFFVIVIF LGSFYLVNLI LAVVTMAYEE QNQATIAEIE AKEKTFQEAL
     ERRRKEQEVL LAMGIDTASL PSRNGSPLGS KNTSERRHRM KSRASEGSTE DNKSPQSEQY
     NQRRMSFLGL TSGRRRASHG NAFHFRAPGQ DVSFPDGIAD DGVFHGDHES RQGSLLLGRG
     AGQQGSLPRS PLPQPPNPGS RHEEEGHPTL PAIELPPGAT EVLAFDAGQK KIFLSADYLN
     EPFRAQRAMS VVSIMTSVIE ELEESERKCP PCLTSLAQKY LIWECCPTWL KLKEVLFKLV
     TDPFAELTIT LCIVVNTIFM AMEHHGMSSA FESMLQIGNI VFTIFFTAEM VFKIIAFDPY
     YYFQKKWNIF DCVIVTVSLL ELSMVKKGSL SVLRTFRLLR VFKLAKSWPT LNTLIKIIGN
     SVGALGNLTI ILAIIVFIFA LVGKQLLGEA YCTKGNILPG DEPPRWHMHD FFHSFLIVFR
     ILCGEWIENM WACMQVSEKP LCLILFLTVM VLGNLVVLNL FIALLLNSFS ADNLTTPDDD
     GEVNKLQVAL GRLQVFGRQT RRALRGFFCR LCLLAGPKVE SQLTEKPPLS SSKAENHIAA
     SGSPRAPPPP RGPSAEHNDF ITNPNLWVSV PIAEGESDLD DSEDGEQDAP NSWPGTLEGL
     QEQLPQAERC GDHLTPRSPC SGTSSEDLAP FQGGKRKGDN GAPPDRTQVM DDTSSSEGST
     VDCPDPEEIL RKIPELADDL QEPDDCFTEG CLRYCPCCNV NITKLPWAMG WQLRKTCYRI
     VEHSWFESFI IFMILLSSGS LAFEDCYLDQ KPTVKALLEY TDRVFTFIFV FEMLLKWVAY
     GFKKYFTNAW CWLDFLIVNI SLVSLTAKIL EYSDVESIKA LRTLRALRPL RALSRFEGMR
     VVVDALLGAI PSIMNVLLVC LIFWLIFSIM GVNLFAGKFG RCINQTNGDF ALVNWTVVNN
     MSECENQNYT GHLFWVNVKV NFDNVMMGYL ALLQVATFKG WMDIMYAAVD SREVNSQPKW
     EDNVYMYLYF VIFIIFGGFF TLNLFVGVII DNFNQQKKKI RGQDIFMTEE QKKYYNAMKK
     LGSKKPQKPI PRPLNKYQGF VFDIVTKQAF DISIMVLICL NMITMMVETD DQSKEKTQVL
     GKINQFFVAV FTGECVLKMF ALRHYYFTNG WNVFDLIVVL LSISSLIFSA ILTSIESYFS
     PTLFRVIRLA RIGRILRLIR AAKGIRTLLF ALMMSLPALF NIGLLLFLVM FIYSIFGMSS
     FPHVKEEAGI DDMFNFKTFA NSMLCLFQIT TSAGWDALLS PILNTGPPYC NGTRGDCGSP
     AVGIFFFTTY IIISFLIVVN MYIAVILENF NAATEESTEP LSEDDFDMFY ETWEKFDPEA
     TQFITFSALS DFADTLSGPL RIPKPNRNIL IQMDLPLVPG DKIHCLDILF AFTKKVLGES
     GELDTLKASM EEKFMATNLS KTSYEPIATT LRWKQEDISA TVIQKAYRSY VQHRSLACSN
     SSGVPRAEEE AESLPGEGFV AFMANENYAL PDKSETASAT SFPPSYDSVT RGLNDRITMS
     TSSSIQNEDE AMSKAVTDPG PQ
//
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