GenomeNet

Database: UniProt
Entry: H0VQI0_CAVPO
LinkDB: H0VQI0_CAVPO
Original site: H0VQI0_CAVPO 
ID   H0VQI0_CAVPO            Unreviewed;      1520 AA.
AC   H0VQI0;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 2.
DT   22-NOV-2017, entry version 43.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN7A {ECO:0000313|Ensembl:ENSCPOP00000012802};
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricomorpha; Caviidae; Cavia.
OX   NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000012802};
RN   [1] {ECO:0000313|Ensembl:ENSCPOP00000012802}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000012802};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSCPOP00000012802}
RP   IDENTIFICATION.
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000012802};
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCPOP00000012802}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AAKN02005745; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02005746; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02005747; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 10141.ENSCPOP00000012802; -.
DR   Ensembl; ENSCPOT00000014352; ENSCPOP00000012802; ENSCPOG00000014210.
DR   eggNOG; ENOG410INF4; Eukaryota.
DR   eggNOG; ENOG410Y1Z2; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; H0VQI0; -.
DR   OMA; GMYNFAY; -.
DR   OrthoDB; EOG091G00FK; -.
DR   TreeFam; TF323985; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   Bgee; ENSCPOG00000014210; -.
DR   GO; GO:0097386; C:glial cell projection; IEA:Ensembl.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   GO; GO:0006936; P:muscle contraction; IEA:InterPro.
DR   GO; GO:0055078; P:sodium ion homeostasis; IEA:Ensembl.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028812; Na_channel_a7su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   PANTHER; PTHR10037:SF14; PTHR10037:SF14; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00170; NACHANNEL.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005447};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
SQ   SEQUENCE   1520 AA;  174991 MW;  81D8D0169CE07262 CRC64;
     VMASPELKGL VPFSRKSLEL IKQHIAKKHS EENEEDDLKP NPDLNVGKKL PLLYGNLSGE
     MVSEPLEDVD PYYYNKKTFM VLNKNRTIFR FNAASIFCTL SPFSTIRGTT IKVLIHPYPF
     LLYSLMDNVL FLLLLLIQKF FCRHTLLGIY TFEILVKVIA RGIGAGPFSF LGDPWNWLDF
     SVTLFEIVTR FSSLNLTHML ESVRTLRILK IIPLNQGLKS LVGILIHCLK KLSGAIILTL
     FFLSIFSLIG MGLFMGNLKH KCLWWPQENK NETLYNRTGN PHYIPETESF YYLEGEEDAL
     LCGNRTDASQ CPEGYVCVKA GKNPDRGSSN FDNFGWAFLA LFRLMAQDYP EALYHQILYA
     SGKIYMLFFV VVTFWFAFYM ASLFIGILSM AYEEEKKAAS EKTETKATFQ QTIKALQEGN
     GAAENKSTQI EMKKRSPAFL STSVDMLEES TSGHNEELKK SRKKCPLCWY KIAKTFLIWD
     CSPCWQKLKN FVHRIIMDPF TDLFLIICII LNILFLALEH YPMSEDTWSL LFFGNMVFIG
     IFTAEMILKI IAMHPYQYFQ VGWNIFDSII VLFGLAEFYL ANIAGLGDFR QLRILGKYWP
     TFRKLMLTLS NSLMALRDII LLLFTFVFFS AVFGMRLFGE SYKECVCRID KDCRLPRWHM
     HDFFHSYLIV FRILCGEWIE TLWDCMEVAG PSSCICFYMM VILIGNLLKI KQSSSSECST
     VDIATSEEEM VNEHESHQND RRRSSPSQIS KEYKKKKIWQ NIRKTCCKIV ENSWFKCFIG
     LVTLLSTGAL AFEDIYIDQR KTIKILLEYA DMIFTYIFIL EMLLKWMAYG FKAYFCNAWH
     RLDFIVVIVF CLSLIGKTRE DLKPLTSIKF LRAIRVLSQF ERMKVVVRTL IKTTLPTLNV
     FLVCFMIWLT FSIMGVHLFA GKFYACTDQP NGEKLPVSEV LNRSQCESHL YNESLSWENA
     QLNFDNVGNG LLSLLQVATF NGWIDIVYSA IDSLDVNMQP SFESNLYMYC YFIAFVILGL
     FLPLSMLIGV IITNFNKHKI KISSNMFITA KQKKQYRWLK RLMYDDSPKP IPRPGNKLQG
     FIFDLVTSRV FNVIIMVLIC LQAIIIMMES DEQSPQMYAV IFWINSTFVI LYTAECVLKL
     ISFHCYYFTS IWNILDFMVV VFSITGLFLP LTVGYYLVPP SLVQLVLLSR IIHILRRGKG
     PKVFHDLMLP LLLSLPALMN ISLLIFLVMF IYAIFGMYNF AYVKKEAGIN DVSNFETFCS
     SMICLFQVTI FAGWDGLLNA VFNSKWSDCD PDKINPGTQV RGDCGNPSVG IFYFVSYIFI
     IWLIIVNMYI AVIMEFLSIV SKKKTRSLSE YDFRKFFQVW ERFDPDRTQY IDSCKLSDFA
     AALDPPLFMA KPNKGQLVAM DLPMAVGDRI HCLDVLLAFT KRVVGKDAGT EKTLSEIESA
     FALANPIKIT YEPITTTLKR KQETVSATII QRAYKNYRSR QNDKNTADIS ILDSGQELQD
     TKKGVCLGKV KEKSAIQSQI
//
DBGET integrated database retrieval system