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Database: UniProt
Entry: H0VQI0_CAVPO
LinkDB: H0VQI0_CAVPO
Original site: H0VQI0_CAVPO 
ID   H0VQI0_CAVPO            Unreviewed;      1700 AA.
AC   H0VQI0;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   30-AUG-2017, entry version 41.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN7A {ECO:0000313|Ensembl:ENSCPOP00000012802};
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricomorpha; Caviidae; Cavia.
OX   NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000012802};
RN   [1] {ECO:0000313|Ensembl:ENSCPOP00000012802}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000012802};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSCPOP00000012802}
RP   IDENTIFICATION.
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000012802};
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCPOP00000012802}.
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DR   EMBL; AAKN02005745; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02005746; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02005747; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 10141.ENSCPOP00000012802; -.
DR   Ensembl; ENSCPOT00000014352; ENSCPOP00000012802; ENSCPOG00000014210.
DR   eggNOG; ENOG410INF4; Eukaryota.
DR   eggNOG; ENOG410Y1Z2; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; H0VQI0; -.
DR   OMA; GMYNFAY; -.
DR   OrthoDB; EOG091G00FK; -.
DR   TreeFam; TF323985; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   Bgee; ENSCPOG00000014210; -.
DR   GO; GO:0097386; C:glial cell projection; IEA:Ensembl.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   GO; GO:0006936; P:muscle contraction; IEA:InterPro.
DR   GO; GO:0055078; P:sodium ion homeostasis; IEA:Ensembl.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028812; Na_channel_a7su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   PANTHER; PTHR10037:SF269; PTHR10037:SF269; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00170; NACHANNEL.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005447};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    240    262       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    380    400       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    531    549       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    561    584       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    596    620       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    641    669       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    731    751       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    992   1011       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1017   1034       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1077   1099       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1185   1211       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1270   1288       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1300   1318       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1325   1349       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1387   1415       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1491   1517       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      122    406       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      531    745       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      951   1217       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1269   1518       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   1700 AA;  194810 MW;  C417EBEFFC308D26 CRC64;
     VMASPELKGL VPFSRKSLEL IKQHIAKKHS EENEEDDLKP NPDLNVGKKL PLLYGNLSGE
     MVSEPLEDVD PYYYNKKYNT FMVLNKNRTI FRFNAASIFC TLSPFSTIRG TTIKVLIHPP
     TLFQLLILIS VLTDCILMTM INGPEWEPAV EHTLLGIYTF EILVKVIARG IGAGPFSFLG
     DPWNWLDFSV TLFEIVTRFS SLNLTHMLES VRTLRILKII PLNQGLKSLV GILIHCLKKL
     SGAIILTLFF LSIFSLIGMG LFMGNLKHKC LWWPQENKNE TLYNRTGNPH YIPETESFYY
     LEGEEDALLC GNRTDASQCP EGYVCVKAGK NPDRGSSNFD NFGWAFLALF RLMAQDYPEA
     LYHQLIYSFK KFYKIVSIKI IFWFATDMAS LFIGILSMAY EEEKKAASEK TETKATFQQT
     IKALQEGNGA AELTFIWFLS TRFCDKYIPH FCVPDNKSTQ IEMKKRSPAF LSTSVDMLEE
     STSGHNSELK KSRKKCPLCW YKIAKTFLIW DCSPCWQKLK NFVHRIIMDP FTDLFLIICI
     ILNILFLALE HYPMSEDTWS LLFFGNMFVF ALHTAEMILK IIAMHPYQYF QVGWNIFDSI
     IVLFGLAEFY LANIAGLGDF RQLRILRIFK LGKYWPTFRK LMLTLSNSLM ALRDIILLLF
     TFVFFSAVFG MRLFGESYKE CVCRIDKDCR LPRWHMHDFF HSYLIVFRIL CGEWIETLWD
     CMEVAGPSSC ICFYMMVILI GNLLLRCPVM GLNNPETSSS AGPDQLKCGW SNTRCVVLVY
     NLITPSSIGI ILRNNTFTRL TLCQNCFCII SQPISDSSLY QIFGTSTVLK HFEQNSSCIC
     TYVHMSTYTS LIPSPSVSES VPASGESDIE YADNKKTIPS VLNFSSKNEK IKQSSSSECS
     TVDIATSEEE MVNEHERLKH LITDRRRSSP SQISKEFWQN IRKTCCKIVE NSWFKCFIGL
     VTLLSTGALA FEDIYIDQRK TIKILLEYAD MIFTYIFILE MLLKWMAYGF KAYFCNAWHR
     LDFIVVIVFC LSLIGKTRED LKPLTSIKFL RAIRVLSQFE RMKVVVRTLI KTTLPTLNVF
     LVCFMIWLTF SIMGVHLFAG KFYACTDQPN GEKLPVSEVL NRSQCESHLY NESLSWENAQ
     LNFDNVGNGL LSLLQVATFN GWIDIVYSAI DSLDVDMQPS FESNLYMYCY FIAFVILGLF
     LPLSMLIGVI ITNFNKHKIK QGGSNMFITA KQKKQYRWLK RLMYDDSPKP IPRPGNKLQG
     FIFDLVTSRV FNVIIMVLIC LQAIIIMMES DEQSPQMYAV IFWINSTFVI LYTAECVLKL
     ISFHCYYFTS IWNILDFMVV VFSITGLFLP LTVGYYLVPP SLVQLVLLSR IIHILRRGKG
     PKVFHDLMLP LLLSLPALMN ISLLIFLVMF IYAIFGMYNF AYVKKEAGIN DVSNFETFCS
     SMICLFQVTI FAGWDGLLNA VFNSKWSDCD PDKINPGTQV RGDCGNPSVG IFYFVSYIFI
     IWLIIVNMYI AVIMEFLSIV SKKKTRSLSE YDFRKFFQVW ERFDPDRTQY IDSCKLSDFA
     AALDPPLFMA KPNKGQLVAM DLPMAVGDRI HCLDVLLAFT KRVVGKDAGT EKTLSEIESA
     FALANPIKIT YEPITTTLKR KQETVSATII QRAYKNYRSR QNDKNTADIS ILDSGQELQD
     TKKGVCLGKV KEKSAIQSQI
//
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