GenomeNet

Database: UniProt
Entry: H0VQI0_CAVPO
LinkDB: H0VQI0_CAVPO
Original site: H0VQI0_CAVPO 
ID   H0VQI0_CAVPO            Unreviewed;      1520 AA.
AC   H0VQI0;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 2.
DT   31-JAN-2018, entry version 45.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN7A {ECO:0000313|Ensembl:ENSCPOP00000012802};
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricomorpha; Caviidae; Cavia.
OX   NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000012802};
RN   [1] {ECO:0000313|Ensembl:ENSCPOP00000012802}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000012802};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSCPOP00000012802}
RP   IDENTIFICATION.
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000012802};
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCPOP00000012802}.
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DR   EMBL; AAKN02005745; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02005746; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02005747; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 10141.ENSCPOP00000012802; -.
DR   Ensembl; ENSCPOT00000014352; ENSCPOP00000012802; ENSCPOG00000014210.
DR   eggNOG; ENOG410INF4; Eukaryota.
DR   eggNOG; ENOG410Y1Z2; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; H0VQI0; -.
DR   OMA; GMYNFAY; -.
DR   OrthoDB; EOG091G00FK; -.
DR   TreeFam; TF323985; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   Bgee; ENSCPOG00000014210; -.
DR   GO; GO:0097386; C:glial cell projection; IEA:Ensembl.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   GO; GO:0006936; P:muscle contraction; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   GO; GO:0055078; P:sodium ion homeostasis; IEA:Ensembl.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028812; Na_channel_a7su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   PANTHER; PTHR10037:SF14; PTHR10037:SF14; 2.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00170; NACHANNEL.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005447};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM     87    106       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    118    137       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    235    255       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    364    392       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    495    518       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    530    551       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    563    581       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    619    638       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    689    708       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    806    826       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    838    855       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    898    920       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1006   1032       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1090   1108       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1120   1138       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1145   1169       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1207   1235       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1311   1337       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      142    398       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      500    708       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      772   1037       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1089   1338       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   1520 AA;  174991 MW;  81D8D0169CE07262 CRC64;
     VMASPELKGL VPFSRKSLEL IKQHIAKKHS EENEEDDLKP NPDLNVGKKL PLLYGNLSGE
     MVSEPLEDVD PYYYNKKTFM VLNKNRTIFR FNAASIFCTL SPFSTIRGTT IKVLIHPYPF
     LLYSLMDNVL FLLLLLIQKF FCRHTLLGIY TFEILVKVIA RGIGAGPFSF LGDPWNWLDF
     SVTLFEIVTR FSSLNLTHML ESVRTLRILK IIPLNQGLKS LVGILIHCLK KLSGAIILTL
     FFLSIFSLIG MGLFMGNLKH KCLWWPQENK NETLYNRTGN PHYIPETESF YYLEGEEDAL
     LCGNRTDASQ CPEGYVCVKA GKNPDRGSSN FDNFGWAFLA LFRLMAQDYP EALYHQILYA
     SGKIYMLFFV VVTFWFAFYM ASLFIGILSM AYEEEKKAAS EKTETKATFQ QTIKALQEGN
     GAAENKSTQI EMKKRSPAFL STSVDMLEES TSGHNEELKK SRKKCPLCWY KIAKTFLIWD
     CSPCWQKLKN FVHRIIMDPF TDLFLIICII LNILFLALEH YPMSEDTWSL LFFGNMVFIG
     IFTAEMILKI IAMHPYQYFQ VGWNIFDSII VLFGLAEFYL ANIAGLGDFR QLRILGKYWP
     TFRKLMLTLS NSLMALRDII LLLFTFVFFS AVFGMRLFGE SYKECVCRID KDCRLPRWHM
     HDFFHSYLIV FRILCGEWIE TLWDCMEVAG PSSCICFYMM VILIGNLLKI KQSSSSECST
     VDIATSEEEM VNEHESHQND RRRSSPSQIS KEYKKKKIWQ NIRKTCCKIV ENSWFKCFIG
     LVTLLSTGAL AFEDIYIDQR KTIKILLEYA DMIFTYIFIL EMLLKWMAYG FKAYFCNAWH
     RLDFIVVIVF CLSLIGKTRE DLKPLTSIKF LRAIRVLSQF ERMKVVVRTL IKTTLPTLNV
     FLVCFMIWLT FSIMGVHLFA GKFYACTDQP NGEKLPVSEV LNRSQCESHL YNESLSWENA
     QLNFDNVGNG LLSLLQVATF NGWIDIVYSA IDSLDVNMQP SFESNLYMYC YFIAFVILGL
     FLPLSMLIGV IITNFNKHKI KISSNMFITA KQKKQYRWLK RLMYDDSPKP IPRPGNKLQG
     FIFDLVTSRV FNVIIMVLIC LQAIIIMMES DEQSPQMYAV IFWINSTFVI LYTAECVLKL
     ISFHCYYFTS IWNILDFMVV VFSITGLFLP LTVGYYLVPP SLVQLVLLSR IIHILRRGKG
     PKVFHDLMLP LLLSLPALMN ISLLIFLVMF IYAIFGMYNF AYVKKEAGIN DVSNFETFCS
     SMICLFQVTI FAGWDGLLNA VFNSKWSDCD PDKINPGTQV RGDCGNPSVG IFYFVSYIFI
     IWLIIVNMYI AVIMEFLSIV SKKKTRSLSE YDFRKFFQVW ERFDPDRTQY IDSCKLSDFA
     AALDPPLFMA KPNKGQLVAM DLPMAVGDRI HCLDVLLAFT KRVVGKDAGT EKTLSEIESA
     FALANPIKIT YEPITTTLKR KQETVSATII QRAYKNYRSR QNDKNTADIS ILDSGQELQD
     TKKGVCLGKV KEKSAIQSQI
//
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