ID H0VS84_CAVPO Unreviewed; 2111 AA.
AC H0VS84;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Sidekick cell adhesion molecule 1 {ECO:0000313|Ensembl:ENSCPOP00000013478.3};
GN Name=SDK1 {ECO:0000313|Ensembl:ENSCPOP00000013478.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000013478.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000013478.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000013478.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAKN02032192; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02032193; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02032194; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02032195; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02032196; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 10141.ENSCPOP00000013478; -.
DR Ensembl; ENSCPOT00000015102.3; ENSCPOP00000013478.3; ENSCPOG00000014956.4.
DR VEuPathDB; HostDB:ENSCPOG00000014956; -.
DR eggNOG; KOG0200; Eukaryota.
DR eggNOG; KOG3510; Eukaryota.
DR GeneTree; ENSGT00940000157747; -.
DR HOGENOM; CLU_001875_1_0_1; -.
DR InParanoid; H0VS84; -.
DR OMA; FMDADQR; -.
DR TreeFam; TF316846; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000014956; Expressed in zone of skin and 8 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0048148; P:behavioral response to cocaine; IEA:Ensembl.
DR GO; GO:0060998; P:regulation of dendritic spine development; IEA:Ensembl.
DR CDD; cd00063; FN3; 13.
DR CDD; cd00096; Ig; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 19.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR PANTHER; PTHR44170:SF30; FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR Pfam; PF00041; fn3; 13.
DR Pfam; PF07679; I-set; 3.
DR Pfam; PF13927; Ig_3; 3.
DR PRINTS; PR00014; FNTYPEIII.
DR SMART; SM00060; FN3; 13.
DR SMART; SM00409; IG; 6.
DR SMART; SM00408; IGc2; 5.
DR SUPFAM; SSF49265; Fibronectin type III; 7.
DR SUPFAM; SSF48726; Immunoglobulin; 5.
DR PROSITE; PS50853; FN3; 13.
DR PROSITE; PS50835; IG_LIKE; 5.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1908..1931
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 4..86
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 193..281
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 286..376
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 380..469
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 474..563
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 570..666
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 671..767
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 772..870
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 874..968
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 972..1071
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1076..1174
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1179..1276
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1280..1374
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1379..1476
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1481..1599
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1604..1700
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1701..1799
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1802..1900
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
SQ SEQUENCE 2111 AA; 231990 MW; 8BF6090389BEFCA5 CRC64;
DVAPYFKTEP GLPQIHLEGN RLVLTCLAEG SWPLEFKWMH NDSELTTYST EYKYIISSLQ
KHDAGFYRCV VRNRMGALLQ RKSEVQVAYM GNFMDTDQRK MVSQGHAAVL NLLPINSCPR
PQVTWFREGH KIIPSNRIAI TLENQLVILS TTASDAGAYY VQAVNERNGE NKTSPFIHLS
IARDMGTPEA MAPVIVVAPG NRSVVAGSSE TTLECIASAR PVEELSVHWK RNGVRLTSGL
HSFGRRLTIS NPTSTDTGLY VCEATLRGSA FEPARAKAFL SIIEPPYFTA EPESRILVEV
EETVDIMCRA MGVPLPTLQW YKDAVSINKL QNPRYQVLPS GGLRIQKLHP EDSGIFQCFA
SNEGGEIQTH TYLDVTNVAP TFIQCPADTT VTDGMTAVLR CEVSGAPKPA VTWKRGNNIL
ASGSVRIPRF MLLESGGLQI TPVFIQDAGN YTCYALNTEG SLNASATLTV WNRTSIIHPP
EDRVVIKGTT AALHCGATHD PRISLRYVWK KDNAVITPSS SSRIVVEKDG SLLISQTWSG
DIGDYTCEIV SEGGNDSRTA RLEVIELPHP PQNLLASLSP SHSHAVVLSW VRPFDGNSPV
LHYIVELSEN NSPWKVHLSD VGPEMTGITV SGLTPARTYQ FRVCAVNQVG KGQYSTETSR
LMLPEEPPSA PPKNIVASGR TNQSIMVQWQ PPPETEHNGV LHGYILRYRL AGLPGEHQQR
NITSPEVNYC LVTDLIIWTQ YEIQVAAYNG AGLGVFSRAV AEYTLQGVPT APPQNVQAEA
VNSTTVQFLW NPPPQQFING INQGYKLLAW PADVPEAVTV LTIAPDFHGI HHGYITNLKK
FTAYFTSVLC FTTPGDGPPS TPQLVWTHED KPGAVGHLSF TEILDTSLKV SWQEPLEKNG
IITGYRISWE VYGKNDSRLT HTLNSTTHEY KIRGLSSLTT YTIEVAAVTA AGMGLVTTST
ISSGVPPDLP GAPSNLVISN ISPRSATLQF RPGYDGKTSI SRWIVEGQVG AIGDEEEWVC
LYEEENEPDA QMLEIPNLTP YTHYRFRMRQ VNIVGPSPFS QSSRVIQTLQ APPDVAPTSI
TVRTASETSL RLRWVPLPDS QYNGNPESVG YRVKYWRLDL PSSALAQVVN DRLERELTIE
ELEEWTEYEL QMQAFNAIGA GPWSEVVRGR TRESVPSAAP ENVSAEAVSS TQILLTWASV
PEQDQNGLIL GYKILYRAKD LDPEPRTHVV RGNHTQSALL AGLRKFVLYE LQVLAFTRIG
NGVPSSPFIL ERTKDDAPGP PVRLVFPEVR LTSVRIVWQP PEEPNGVILG YQIAYRLASS
RPHTFTTVEV GATVRQFTAT ELAPESAYVF RLSAKTRQGW GEPLEATVIT TEKRERPAPP
RELQVPQAEV TARSLQLQWV PGSDGASPIR YFTVQVRELP GGEWQTYSSS ISHDATACAV
ERLRPFTSYK LRLKATNDIG DSNFSSETEA VTTLQDVPGE PPGSVSATPH TTSSVLIQWQ
PPRDESLNGL LQGYRIYYRE LESEAGTSPE AKMLKSPSAL RAELTAQSSF KTVNSSSTLT
TYELTHLKKY RRYEVIMTAY NVIGESPASA PVEVFVGEAA PAMAPQNIQV TPLTASQLEV
TWDPPPPESQ NGNIQGYKIY YWEAGNRNET EKMKVLFLPE PTVKLKNLTS HTKYLVSISA
FNAAGDGPRS DPRQGRTHQA APGALSFLAF SEITSTTLNV SWGEPVAANG VLQGYRVVYE
PLAPVQGVSK VVTVDVKGNW QRWLKVRDLT KGVTYFFRVQ ARTITYGPEL QANVTAGPAE
GSPGSPKDVL VTKSTSDLTL QWTEGSPGNS PTTGFVIEAR PSDEGLWDMF VKDIPRSATS
YTISLDKLRQ GVTYEFRVVA ANEAGYGEPS RPSPAVSAQV EAPFYEEWWF LLVMALSSLI
IILLVVFALV LHGQNKKYKS CGAGKSISNM EESVTLDNGG FAALELNSRH LNVKSTFLKK
NGTRSPPRPS PGGLRYSDED ICNKYNGAVL TESMSLKEKS VGTSESEASD SDYEDALPKH
SFVNHYMSDP TYYNSWKRRP PAAAPHRYEA VAGAEAAQHP HPVITTQSAG GVYTPAGPGT
RAPLTGFSSF V
//
