ID H0VSJ2_CAVPO Unreviewed; 958 AA.
AC H0VSJ2;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Oncostatin M receptor {ECO:0000313|Ensembl:ENSCPOP00000013600.3};
GN Name=OSMR {ECO:0000313|Ensembl:ENSCPOP00000013600.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000013600.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000013600.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000013600.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 2
CC subfamily. {ECO:0000256|ARBA:ARBA00008921}.
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DR EMBL; AAKN02031784; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_013008320.1; XM_013152866.1.
DR RefSeq; XP_013008321.1; XM_013152867.1.
DR RefSeq; XP_013008322.1; XM_013152868.1.
DR RefSeq; XP_013008323.1; XM_013152869.1.
DR AlphaFoldDB; H0VSJ2; -.
DR STRING; 10141.ENSCPOP00000013600; -.
DR Ensembl; ENSCPOT00000015233.3; ENSCPOP00000013600.3; ENSCPOG00000015086.4.
DR GeneID; 100716168; -.
DR KEGG; cpoc:100716168; -.
DR CTD; 9180; -.
DR VEuPathDB; HostDB:ENSCPOG00000015086; -.
DR eggNOG; ENOG502QWRV; Eukaryota.
DR GeneTree; ENSGT00940000160851; -.
DR HOGENOM; CLU_012673_0_0_1; -.
DR InParanoid; H0VSJ2; -.
DR OMA; GKMMQYN; -.
DR OrthoDB; 5347052at2759; -.
DR TreeFam; TF338122; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000015086; Expressed in uterine cervix and 13 other cell types or tissues.
DR GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR GO; GO:0005900; C:oncostatin-M receptor complex; IEA:Ensembl.
DR GO; GO:0019838; F:growth factor binding; IEA:Ensembl.
DR GO; GO:0004924; F:oncostatin-M receptor activity; IEA:Ensembl.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl.
DR CDD; cd00063; FN3; 4.
DR Gene3D; 2.60.40.10; Immunoglobulins; 7.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR003529; Hematopoietin_rcpt_Gp130_CS.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR048497; LIF-R-like_Ig-like.
DR InterPro; IPR040817; LIFR_D2.
DR PANTHER; PTHR23036; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR23036:SF95; ONCOSTATIN-M-SPECIFIC RECEPTOR SUBUNIT BETA; 1.
DR Pfam; PF00041; fn3; 3.
DR Pfam; PF21177; LIF-R_Ig-like; 1.
DR Pfam; PF17971; LIFR_D2; 1.
DR SMART; SM00060; FN3; 4.
DR SUPFAM; SSF49265; Fibronectin type III; 3.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS01353; HEMATOPO_REC_L_F2; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..958
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5011471457"
FT TRANSMEM 732..753
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 326..420
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 424..521
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 617..728
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
SQ SEQUENCE 958 AA; 107714 MW; A2AA1F59C03BEF80 CRC64;
MAFFAVFPAV FFLALLSWRT CQSEVLAEHL PLTPESLSVS FSSSLQRLDL QWTVHKLPYQ
ELQMVFPIEI SRTETSKVIW MGNYSTIVKR NQVLHWSWES ELPLECATHF VRIKSIVNDA
RFPELSFESN WSSWEEVHAH TPGQKPLLFP KDKLVEEGAN VTFCFNSGRK HGMSCYLEEE
LIHGEQLDSN IFTFKLTNVP FIRQEGTHVY CGVNYDLLDG TVLFVSKVLE EPKNFSCETQ
DLKTLNCTWD PGVDTSLSYD RQQQNYILFE SFSGKEKYCE HNKWCTWEIS QDLEATYNFT
LTAENYLRKR SVNSAFKPID RVHPKAPESV QFENVGATSA VVTWKIPVLG NYFTLLCQIE
LHDKEDVRRE HNVSIKVNGE FLFSELEPDT EYVVHIRCAN SKRFWKWSEW VTHTLVTAQA
APSKALDVWR IVKSSKGFHN VTLFWKPLSK SHANGKILFY NIAAKNLDNE SELKLLRIPA
PANGTELTLD QGSYQIQVTA NNSVGTSPAS EIVIAADSGN EEVEEEKING TNDGFLISWK
PQSGEVTSYI VEWCEHPQNL HCDLQWKNLG PNTTETFISS EAFTPGIRYS FRIYKLSTEK
TAYLVEKKTG YSQELAPLDS PQVAVKNLTS HSFTLSWEDY DTERQPGFIR GYYVCLKSNA
THCHPGSVKE SLPDKSTCCK HDISDPKQKT FLVKDLQPES FYEFSVSSYT SAGEGPNGTF
TKVTTPEGRS HMLIYVVLPM TLCVLLIAIT CYWKSQWVKE KCYPDIPDPY KSSILSLIKS
KENPRITIMN VKDCIPDAIE VINKSEGTKA GCMGTLKPLT GSESSKPANN YQDFPCPAAC
ISFENLTYNE SACDSGSCAY IPGPATALPC QLGLLASPDN LPNTAEDAHT NFQGDIPAGE
ISLNYVAQLA SPMSGDKDGL LINPPAPELC SEYKMQMAVP SHLSSPVPSE MAASPEPF
//
