ID H0VTQ6_CAVPO Unreviewed; 508 AA.
AC H0VTQ6;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=Enhancer of mRNA-decapping protein 3 {ECO:0000256|ARBA:ARBA00015797};
DE AltName: Full=YjeF domain-containing protein 1 {ECO:0000256|ARBA:ARBA00032192};
GN Name=EDC3 {ECO:0000313|Ensembl:ENSCPOP00000014063.2};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000014063.2, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000014063.2}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000014063.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, P-body
CC {ECO:0000256|ARBA:ARBA00004201}.
CC -!- SIMILARITY: Belongs to the EDC3 family.
CC {ECO:0000256|ARBA:ARBA00006610}.
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DR EMBL; AAKN02050773; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02050774; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02050775; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02050776; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003463630.1; XM_003463582.3.
DR RefSeq; XP_013001075.1; XM_013145621.1.
DR RefSeq; XP_013001077.1; XM_013145623.1.
DR AlphaFoldDB; H0VTQ6; -.
DR STRING; 10141.ENSCPOP00000014063; -.
DR Ensembl; ENSCPOT00000015747.3; ENSCPOP00000014063.2; ENSCPOG00000015595.4.
DR GeneID; 100725172; -.
DR KEGG; cpoc:100725172; -.
DR CTD; 80153; -.
DR VEuPathDB; HostDB:ENSCPOG00000015595; -.
DR eggNOG; KOG2585; Eukaryota.
DR GeneTree; ENSGT00390000016435; -.
DR HOGENOM; CLU_026194_0_0_1; -.
DR InParanoid; H0VTQ6; -.
DR OMA; KNRDDEC; -.
DR OrthoDB; 4100524at2759; -.
DR TreeFam; TF324695; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000015595; Expressed in testis and 13 other cell types or tissues.
DR GO; GO:0000932; C:P-body; IEA:UniProtKB-SubCell.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0003729; F:mRNA binding; IEA:InterPro.
DR GO; GO:0031087; P:deadenylation-independent decapping of nuclear-transcribed mRNA; IEA:InterPro.
DR CDD; cd01737; LSm16_N; 1.
DR Gene3D; 2.30.30.100; -; 1.
DR Gene3D; 3.40.50.10260; YjeF N-terminal domain; 1.
DR InterPro; IPR025762; DFDF.
DR InterPro; IPR019050; FDF_dom.
DR InterPro; IPR025609; Lsm14-like_N.
DR InterPro; IPR034107; Lsm16_N.
DR InterPro; IPR047575; Sm.
DR InterPro; IPR004443; YjeF_N_dom.
DR InterPro; IPR036652; YjeF_N_dom_sf.
DR PANTHER; PTHR13612:SF0; ENHANCER OF MRNA-DECAPPING PROTEIN 3; 1.
DR PANTHER; PTHR13612; UNCHARACTERIZED; 1.
DR Pfam; PF16598; Edc3_linker; 1.
DR Pfam; PF09532; FDF; 1.
DR Pfam; PF12701; LSM14; 1.
DR Pfam; PF03853; YjeF_N; 1.
DR SMART; SM01199; FDF; 1.
DR SMART; SM01271; LSM14; 1.
DR SUPFAM; SSF64153; YjeF N-terminal domain-like; 1.
DR PROSITE; PS51512; DFDF; 1.
DR PROSITE; PS52002; SM; 1.
DR PROSITE; PS51385; YJEF_N; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT DOMAIN 1..68
FT /note="Sm"
FT /evidence="ECO:0000259|PROSITE:PS52002"
FT DOMAIN 192..228
FT /note="DFDF"
FT /evidence="ECO:0000259|PROSITE:PS51512"
FT DOMAIN 283..487
FT /note="YjeF N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51385"
FT REGION 98..191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 98..147
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 155..180
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 508 AA; 56097 MW; D88653E733D7C5FA CRC64;
MATDWLGSIV SINCGDSLGV YQGRVSAVDQ VSQTISLTRP FHNGVKCLVP EVTFRAGDIT
ELKILEIPGP GDSHHFGDPH QTELGPSAVG YQVGINQNGT GKLIKKPTSS SSAPQNIPKR
TDVKSQDVAV SPHQQQCSKS YVDRHMEPLS QSKSFRRRHN SWSSSSRHPN QATPKKSGLK
NGQMKNKDDE CFGDDIEEMP DTDFDFEGNL ALFDKAAVFE EIDTYERRTG TRCRGIPNER
PARYRHDENI LESEPIVYRR ITVPHIVSKE FCTDSGLVVP SVSYELHKKL LSVAERHGLT
LERRLEMTGV CASQMALTLL GGPNRLNPKN VHQRPTVALL CGPHVQGAQG ISCGRHLANH
DVQVILFLPN FVKMLESITN ELSLFSKTQG QQVSSLKDLP TSPVDLVINC LDCPENAFLR
DQPWYKAAVA WANQNRAPVL SIDPPVHEAE QGIDAKWSLA LGLPLPLGEH AGRVYLCDIG
IPQQVFQEVG ISYHSPFGCK FVIPLHSA
//