ID H0VU90_CAVPO Unreviewed; 1702 AA.
AC H0VU90;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=SET domain containing 1A, histone lysine methyltransferase {ECO:0000313|Ensembl:ENSCPOP00000014263.1};
GN Name=SETD1A {ECO:0000313|Ensembl:ENSCPOP00000014263.1};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000014263.1, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000014263.1}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000014263.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAKN02007783; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003477932.1; XM_003477884.3.
DR RefSeq; XP_012997158.1; XM_013141704.1.
DR RefSeq; XP_012997159.1; XM_013141705.1.
DR STRING; 10141.ENSCPOP00000014263; -.
DR Ensembl; ENSCPOT00000024181.2; ENSCPOP00000014263.1; ENSCPOG00000025456.2.
DR GeneID; 100715930; -.
DR KEGG; cpoc:100715930; -.
DR CTD; 9739; -.
DR VEuPathDB; HostDB:ENSCPOG00000025456; -.
DR eggNOG; KOG1080; Eukaryota.
DR GeneTree; ENSGT00940000154575; -.
DR HOGENOM; CLU_001226_2_0_1; -.
DR InParanoid; H0VU90; -.
DR OMA; KVSRYPD; -.
DR OrthoDB; 950362at2759; -.
DR TreeFam; TF106436; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000025456; Expressed in pituitary gland and 13 other cell types or tissues.
DR GO; GO:0000785; C:chromatin; IEA:Ensembl.
DR GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR GO; GO:0048188; C:Set1C/COMPASS complex; IEA:Ensembl.
DR GO; GO:0008013; F:beta-catenin binding; IEA:Ensembl.
DR GO; GO:0042800; F:histone H3K4 methyltransferase activity; IEA:Ensembl.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0061629; F:RNA polymerase II-specific DNA-binding transcription factor binding; IEA:Ensembl.
DR GO; GO:0007420; P:brain development; IEA:Ensembl.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:1902275; P:regulation of chromatin organization; IEA:Ensembl.
DR GO; GO:1902036; P:regulation of hematopoietic stem cell differentiation; IEA:Ensembl.
DR CDD; cd12548; RRM_Set1A; 1.
DR CDD; cd19169; SET_SETD1; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR024657; COMPASS_Set1_N-SET.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR003616; Post-SET_dom.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR044570; Set1-like.
DR InterPro; IPR034467; Set1A_RRM.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR037841; SET_SETD1A/B.
DR PANTHER; PTHR45814; HISTONE-LYSINE N-METHYLTRANSFERASE SETD1; 1.
DR PANTHER; PTHR45814:SF3; HISTONE-LYSINE N-METHYLTRANSFERASE SETD1A; 1.
DR Pfam; PF11764; N-SET; 1.
DR Pfam; PF00076; RRM_1; 1.
DR Pfam; PF00856; SET; 1.
DR SMART; SM01291; N-SET; 1.
DR SMART; SM00508; PostSET; 1.
DR SMART; SM00360; RRM; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS50868; POST_SET; 1.
DR PROSITE; PS50102; RRM; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00176}; S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 84..172
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 1563..1680
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 1686..1702
FT /note="Post-SET"
FT /evidence="ECO:0000259|PROSITE:PS50868"
FT REGION 194..320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 333..366
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 380..485
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 505..654
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 833..853
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 893..1243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1260..1286
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1341..1413
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1466..1494
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 206..320
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 427..443
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 460..485
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 560..579
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 592..654
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 893..919
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 928..963
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 970..990
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 991..1014
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1015..1053
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1068..1088
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1113..1134
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1141..1155
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1219..1238
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1353..1369
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1398..1412
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1472..1486
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1702 AA; 185558 MW; 04C88319927D6920 CRC64;
MDQEGGGDGQ KAPSFQWRNY KLIVDPALDP ALRRPSQKVY RYDGIHFSVN DSKYIPVEDL
QDPRCHVRSK NRDFSLPVPK FKLDEFYIGQ IPLKEVTFAR LNDNVRETFL KDMCRKYGEV
EEVEILLHPR TRKHLGLARV LFTSTRGAKE TVKNLHLTSV MGNIIHAQLD IKGQQRMKYY
ELIVNGSYTP QTVPTGGKAL SEKFQGSGAA TETTESRRRS SSDTAAYPSG TAVVGTPGNG
TPCSQDTSFS SSRQDTPSSF GQFTPQSSQG TPYTSRGSTP YSQDSAYSSS TTSTSFKPRR
SENSYQDSFS RRHFSASSVP TTVSTAISAT TAATAASSSS SSSSSSSSTS SSSSSSQFRG
SDSNYPAYYE SWNRYQRHAS YPPRRATREE PSGAPFSEST AERFPPSYTS YLPPEPSRST
DQDYRPPASE APPPEPPEPG GGGGGGGPSP EREEARTSPR AASPTRSGSP APETTNESVP
FAQHSSLDSR IEMLLKEQRS KFSFLASDTE EEEENCSAGS GARDTGSEVP SGSGHGPCTP
PPAPANFEDV APTGSGEPGA TRESPKTNGQ NQASPCSSGE DMEISDDDRG GSPPPAPTPP
QQPPPPPPPP PPPPPYLASL PLGYPPHQPA YLLPPRPDGP PPPEYPPPPP PPPHIYDFVN
SLELMDRLGA QWGGMPMSFQ MQTQMLTRLH QLRQGKGLTA ASAGPPGGAF GEAFLPFPPP
QEAAYGLPYA LYTQGQEGRG AYTREAYHLP LPMAAEPLPS SSVSGEEARL PPREEAELAE
GKALPSAGTV GRVLATLVQE MKSIMQRDLN RKMVENVAFG AFDQWWESKE EKAKPFQNAA
KQQAKEEDKE KTKLKEPGML SLVDWAKSGG TTGIEAFTFG SGLRGALRLP SFKVKRKEPS
EISEASEEKR PRPSTPAEED EDDPERDKEV GEPGRPGSKP PKRDEERGKT QGKHRKSFAL
DSEGEEASQE SSSDKDEEED EEDEEDEDRE EAVDTTKKET EASDGEDEES DASSKCSLYA
DSDGENGSTS DSESSTSSSS SSSSSSSSSS SSSESSEEEE EEEQPTTIPS ASPPPREVPE
PLPAPAKEPE PETAVGSPVV PLPEQEKSPA RPAGPTEEPP PSVPQPPSEP QTGPSAPSPH
LDERPSSPIP LLPPPKKRRK TVSFSTAEEV PAPEPPPAAL PQAKSPGTVS RKVPRGAERT
IRNLPLDHAS LVKSWPEEVS RGGRNRAGGR GRSMEEEEVE PGTEVDLAVL ADLALTPARR
GLAALPPGDD SEATETSDEA DRLCPPLNHI LLEHNYALAI KPTPSTPPPR LPEPVLAPAA
LFSSPADEVL EAPEVVVAEA EEPKPQQQLQ VQQEEGEEEE EEEEESESSE SSSSSSSSDG
DGAGRRRSLR SHARRRRPPL PPPPPPPPSF EPRSEFEQMT ILYDIWNSGL DLEDMSYLRL
TYERLLQQTS GADWLNDTHW VHHTITNLST PKRKRRPQDG PREHQTGSAR SEGYYPISKK
EKDKYLDVCP VSARQLEGVD TQGTNRVLSE RRSEQRRLLS AIGTSAIMDS DLLKLNQLKF
RKKKLRFGRS RIHEWGLFAM EPIAADEMVI EYVGQNIRQM VADMREKRYV QEGIGSSYLF
RVDHDTIIDA TKCGNLARFI NHCCTPNCYA KVITIESQKK IVIYSKQPIG VDEEITYDYK
FPLEDNKIPC LCGTESCRGS LN
//
