ID H0VZA5_CAVPO Unreviewed; 578 AA.
AC H0VZA5;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Otopetrin 1 {ECO:0000313|Ensembl:ENSCPOP00000016037.2};
GN Name=OTOP1 {ECO:0000313|Ensembl:ENSCPOP00000016037.2};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000016037.2, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000016037.2}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000016037.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the otopetrin family.
CC {ECO:0000256|ARBA:ARBA00006513}.
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DR EMBL; AAKN02048961; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0VZA5; -.
DR STRING; 10141.ENSCPOP00000016037; -.
DR Ensembl; ENSCPOT00000027919.2; ENSCPOP00000016037.2; ENSCPOG00000022370.2.
DR VEuPathDB; HostDB:ENSCPOG00000022370; -.
DR eggNOG; KOG4740; Eukaryota.
DR GeneTree; ENSGT00940000159350; -.
DR HOGENOM; CLU_032913_1_0_1; -.
DR InParanoid; H0VZA5; -.
DR OMA; GNVCMRE; -.
DR TreeFam; TF313428; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015252; F:proton channel activity; IEA:Ensembl.
DR GO; GO:0032869; P:cellular response to insulin stimulus; IEA:Ensembl.
DR GO; GO:0009590; P:detection of gravity; IEA:Ensembl.
DR GO; GO:0042472; P:inner ear morphogenesis; IEA:Ensembl.
DR GO; GO:0060336; P:negative regulation of type II interferon-mediated signaling pathway; IEA:Ensembl.
DR InterPro; IPR004878; Otopetrin.
DR PANTHER; PTHR21522; PROTON CHANNEL OTOP; 1.
DR PANTHER; PTHR21522:SF19; PROTON CHANNEL OTOP1; 1.
DR Pfam; PF03189; Otopetrin; 3.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 48..69
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 75..94
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 115..139
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 151..168
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 251..272
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 293..317
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 329..355
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 376..398
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 508..529
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 549..572
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 456..493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 456..474
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 578 AA; 63289 MW; 063A8D8799513379 CRC64;
MLEGLGASAS SAAPASASEP PACPVPRRRG AARSSVPQKL AEALSSQYGL NVFVAGLLFL
LAWAVHAVGV GKRDLLGLLT ALMLLQLLWM LWYVGRSYAQ RRLIRPKDAH AGARWLRGSV
TLFAAITVIL GCFKVGYFIG YSECLSATEG VFPVTHAVHT LLQVYLLWGH AKDIIQSFKT
LERFGVIHSV LTNLLLWANS VLNESKHQLN EHKERLITLG FGNITLELDD HSPPCNCSPA
RLCAALAQGM YYLYPFTIEY QILASTMLFV LWKNIGRSVD GARPLRTGLR LRGILAGSVL
GLGALAATLG VVAMYLVHIG RSKAKSEVAL AMFYLYAMAL LLLMGTAGLL GILIYRVDEK
SLDESKNPAR KLDTDLLVGA ASGSWLLSWG SILAMAFAET RPPYTWYNLL YSVLAIAEKY
IQNLFIIESV HREPEGLPED VCTLRVLTVY NGAASSHLGD SGEAQDTSSV GRQPGLGKEE
QVEPRSGTVA WSSASPGPLF RGSAKRRVLR NITAFLFLCN ISLWIPPAFG CRPEYDNGLE
EVVFGFEPWI IVVNLAMPFS IFYRMHAAAS LFEVYCKM
//
