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Database: UniProt
Entry: H0W256_CAVPO
LinkDB: H0W256_CAVPO
Original site: H0W256_CAVPO 
ID   H0W256_CAVPO            Unreviewed;       187 AA.
AC   H0W256;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   30-AUG-2017, entry version 34.
DE   SubName: Full=Hyperpolarization activated cyclic nucleotide gated potassium channel 1 {ECO:0000313|Ensembl:ENSCPOP00000017047};
GN   Name=HCN1 {ECO:0000313|Ensembl:ENSCPOP00000017047};
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricomorpha; Caviidae; Cavia.
OX   NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000017047};
RN   [1] {ECO:0000313|Ensembl:ENSCPOP00000017047}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000017047};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSCPOP00000017047}
RP   IDENTIFICATION.
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000017047};
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCPOP00000017047}.
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DR   EMBL; AAKN02031627; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02031628; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02031629; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02031630; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02031631; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02031632; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02031633; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02031634; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02031635; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02031636; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSCPOT00000023669; ENSCPOP00000017047; ENSCPOG00000014131.
DR   eggNOG; KOG0498; Eukaryota.
DR   eggNOG; ENOG410XPSE; LUCA.
DR   GeneTree; ENSGT00760000118772; -.
DR   OrthoDB; EOG091G0JQU; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   Bgee; ENSCPOG00000014131; -.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR   GO; GO:0030552; F:cAMP binding; IEA:InterPro.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR   GO; GO:0035725; P:sodium ion transmembrane transport; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR030169; K/Na_HCN1.
DR   PANTHER; PTHR10217:SF567; PTHR10217:SF567; 1.
DR   Pfam; PF00520; Ion_trans; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005447};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT   DOMAIN        2    169       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   187 AA;  21801 MW;  D938816638A7444D CRC64;
     IMMVGNLVII PVGITFFTEQ TTTPWIIFNV ASDTVFLLDL IMNFRTGTVN EDSSEIILDP
     KVIKMNYLKS WFVVDFISSI PVDYIFLIVE KGMDSEVYKT ARALRIVRFT KILSLLRLLR
     LSRLIRYIHQ WEEIFHMTYD LASAVVRIFN LIGMMLLLCH WDGCLQFLVP LLQDFPPDCW
     VSLNKMV
//
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