ID H0W2Z9_CAVPO Unreviewed; 1760 AA.
AC H0W2Z9;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Laminin subunit beta 1 {ECO:0000313|Ensembl:ENSCPOP00000017344.2};
GN Name=LAMB1 {ECO:0000313|Ensembl:ENSCPOP00000017344.2};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000017344.2, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000017344.2}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000017344.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00460}.
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DR EMBL; AAKN02032716; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02032717; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSCPOT00000013302.3; ENSCPOP00000017344.2; ENSCPOG00000013175.4.
DR VEuPathDB; HostDB:ENSCPOG00000013175; -.
DR GeneTree; ENSGT00940000156003; -.
DR HOGENOM; CLU_001560_1_0_1; -.
DR TreeFam; TF312903; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000013175; Expressed in ovary and 12 other cell types or tissues.
DR CDD; cd22300; cc_LAMB1_C; 1.
DR CDD; cd00055; EGF_Lam; 12.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.10.25.10; Laminin; 9.
DR Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 2.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR013015; Laminin_IV_B.
DR InterPro; IPR008211; Laminin_N.
DR InterPro; IPR002049; LE_dom.
DR PANTHER; PTHR10574; NETRIN/LAMININ-RELATED; 1.
DR PANTHER; PTHR10574:SF448; WING BLISTER, ISOFORM B; 1.
DR Pfam; PF00053; Laminin_EGF; 12.
DR Pfam; PF21199; LAMININ_IV_B; 1.
DR Pfam; PF00055; Laminin_N; 1.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00181; EGF; 9.
DR SMART; SM00180; EGF_Lam; 12.
DR SMART; SM00136; LamNT; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 12.
DR SUPFAM; SSF46579; Prefoldin; 1.
DR PROSITE; PS01248; EGF_LAM_1; 5.
DR PROSITE; PS50027; EGF_LAM_2; 10.
DR PROSITE; PS51116; LAMININ_IVB; 1.
DR PROSITE; PS51117; LAMININ_NTER; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00460};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292,
KW ECO:0000256|PROSITE-ProRule:PRU00460};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 30..269
FT /note="Laminin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51117"
FT DOMAIN 270..333
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 397..456
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 523..741
FT /note="Laminin IV type B"
FT /evidence="ECO:0000259|PROSITE:PS51116"
FT DOMAIN 747..794
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 795..840
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 841..890
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 891..949
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 950..1001
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1002..1057
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1058..1105
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1106..1152
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT COILED 1224..1286
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1432..1487
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1535..1748
FT /evidence="ECO:0000256|SAM:Coils"
FT DISULFID 299..308
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 427..436
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 747..759
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 749..766
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 768..777
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 795..807
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 797..814
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 816..825
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 860..869
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 920..929
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 974..983
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1002..1014
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1030..1039
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1058..1070
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1060..1077
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1079..1088
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1106..1118
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1108..1125
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1127..1136
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
SQ SEQUENCE 1760 AA; 194097 MW; 0C62647E63A4E8F6 CRC64;
LTLTPPVALC GPGGVRALDA QEPEFSYGCA EGSCYPATGD LLIGRAQKLS VTSTCGLHKP
EPYCIVSHLQ EDKKCFICNS QEPYHETLNP DSHLIENVVT TFAPNRLKIW WQSESGVENV
TIQLDLEAEF HFTHLIMTFK TFRPAAMLIE RSSDFGRTWG VYRYFAYNCE STFPGISTGP
MKKVDDVICD SRYSDIEPST EGEVIFRALD PAFKIEDPYS PRIQNLLKIT NLRIKFVKLH
TLGDNLLDSR MEIREKYYYA VYDMVVRGNC FCYGHASECA PVDGVSEDVE GMVHGHCMCR
HNTKGLNCEL CMDFYHDLPW RPAEGRNSNA CKKCNCNEHS TSCHFDMAVF LATGNVSGGV
CDDCQHNTMG RSCEQCKPFY YQHPERDVRD PNVCERCTCD PAGSQNGGIC DSYTDFSTGL
IAGQCRCKLH VEGEHCDVCK EGFYDLNAED PLGCKCKSVG RRSGNPAGPQ HWGLSNDLDG
CRPCDCDVGG ALDDSCSSES GQCSCRPHLI GRQCNEVESG YYFTTLDHYI YEAEGASLGP
GVTVVERQYI QDRIPSWTGA GFVRVPEGAY LEFFIDNIPY SMEYEILIRY EPQLPDHWEK
AIITVQRPGK IPTSSRCGNT VPDDDNQMVS LSPGSRYVVL PRPVCFEEGL NYTVRLELPQ
YTSSYSDVES PYTLIDSLVL MPYCKSLDIF TVGGTGDGVV TNSAWETFQR YRCLENSRSV
VKTPMTDVCR GIIFSISALL HQAGLACECD PQGSLSSVCD PNGGQCQCRP NVVGRTCDRC
APGTFGFGPS GCKPCDCHLQ GSVSAFCDAN TGQCPCFQGV YTRQCDRCLP GYWGFPSCQP
CQCNGHADDC DSVTGQCLRC QDYTTGHNCE RCLAGYYGDP VIGSGDHCRP CPCPDGPDSG
RQFARSCYQD PVTLQLACVC EPGYIGSRCD ECAPGFFGNP SDIGGSCQPC QCHHNIDTSD
PQACDKETGR CLKCLYHTEG AHCQLCRSGY YGDAIQQDCR KCVCNSLGTE QQHCNSSDCQ
CDQATGQCSC LPNVIGQNCD RCAPNTWQLA SGTGCQPCGC NAEHSFGPSC NEFTGQCQCM
PGFGGRTCSE CQELFWGNPD VECRACDCDP RGIETPQCNR STGQCICMEG VEGPRCDKCT
RGFSGVFPDC TPCHQCFALW DVIIAELTNR THRFLEKAKA LKISGVIGPY RETVDSVEKK
VNEIRAILAQ SPAAEPLKNI GNLFEEAEKL TKDVTEKIAQ VEGKLSDTAS QSNSTAKELD
LLQAEAESLD NTVKELAEQL EFIKNSDIRG ALDSVTKYFQ MSLEAEERVN ASTTDPNSTV
EQSALMRDRV EGLMLERESQ FREGQEDQAR LLDELAGKLQ SLDLSAAAEM TCGTPPGADC
SESECGGPNC RTEDGEKWCG GPGCGGLVTV AHNAWQKAMD FDRDVLGALA DVEQLSKMIA
EAKLKADEAK QNAQDVLLKT NATKDKVERS NEELRSLIKE IRDFLTQDSA DLDSIEAVAN
EVLKMEMPST PEQLQNLTED IREKVESLSQ VEVILQQSAA DIARAELLLE EAKKTSQSAT
DVKVTADMVK EALEEAEKAQ VAAEKAIKQA DEDIQGTQNL LTSIESETAA SEETLSNASQ
RIIELERNME ELKRKATQNS GEAEYIEKVI HAVKQSADDV KKALDDELDE KYKKVESLIA
KKTEESADAR RKAEMLQNEA KTLLAQANSK LQMLKDLERK YEDNQKYLED KAQELVRLEG
EVRSLLHDIS QQVSIYSTCL
//
