ID H0W3P2_CAVPO Unreviewed; 1733 AA.
AC H0W3P2;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Kinase non-catalytic C-lobe domain containing 1 {ECO:0000313|Ensembl:ENSCPOP00000017589.2};
GN Name=KNDC1 {ECO:0000313|Ensembl:ENSCPOP00000017589.2};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000017589.2, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000017589.2}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000017589.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAKN02002831; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02002832; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02002833; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02002834; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 10141.ENSCPOP00000017589; -.
DR Ensembl; ENSCPOT00000019837.2; ENSCPOP00000017589.2; ENSCPOG00000022244.2.
DR VEuPathDB; HostDB:ENSCPOG00000022244; -.
DR eggNOG; ENOG502QSHW; Eukaryota.
DR GeneTree; ENSGT00390000011408; -.
DR HOGENOM; CLU_003380_0_0_1; -.
DR InParanoid; H0W3P2; -.
DR OMA; CEEKMQL; -.
DR TreeFam; TF336009; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000022244; Expressed in cerebellum and 8 other cell types or tissues.
DR GO; GO:0030425; C:dendrite; IEA:Ensembl.
DR GO; GO:0032045; C:guanyl-nucleotide exchange factor complex; IEA:Ensembl.
DR GO; GO:0043025; C:neuronal cell body; IEA:Ensembl.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0021707; P:cerebellar granule cell differentiation; IEA:Ensembl.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IEA:Ensembl.
DR GO; GO:0048814; P:regulation of dendrite morphogenesis; IEA:Ensembl.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 2.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR011019; KIND_dom.
DR InterPro; IPR029899; KNDC1.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR21560:SF0; KINASE NON-CATALYTIC C-LOBE DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR21560; VERY KIND PROTEIN; 1.
DR Pfam; PF16474; KIND; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00750; KIND; 2.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS51377; KIND; 2.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 37..217
FT /note="KIND"
FT /evidence="ECO:0000259|PROSITE:PS51377"
FT DOMAIN 446..610
FT /note="KIND"
FT /evidence="ECO:0000259|PROSITE:PS51377"
FT DOMAIN 1230..1355
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 1452..1703
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 217..287
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 377..424
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 701..779
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 791..846
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 938..1050
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 239..253
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 254..272
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 385..405
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 722..737
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 743..761
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 798..812
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 938..967
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 987..1009
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1733 AA; 190412 MW; E9BAE4A54C5ED41B CRC64;
MQAMDPAAAG FYEEDVKDLD FYDFEPLPTL PEDEENVSLA DILSLRDSGL SEQEAWAVCL
ECSLSMQSVA HSAIFQTLCI TPDTLAFNTS GNVCFMEQLS DDPEGAFVPP EFDLTGNTFE
AHIYSLGATL KAALEYVTEP ELEPKLSLDL ETLLGQMQAE DPRDRPDLKS IIALCEEKMK
PMSSCRLCRS LSAIGRRVLS IESFGAFQDI SENTWKGRYA PRSVGPKRSP GDLCADPEAL
STSESQTQPP APRDPEQEAN PGPRPPPTKP LLSAPMKNGE NPSGEGLASL VLDTTSLLGE
PGRDILKRNR LRKGPEASAL CLSLTSSKNQ LTLSDFFSPD PRKFLLEGKN GLSSFRAQSK
SRLCPERELR LQREEALGSS HNIDRGPGTL GQHDTSSTDQ GPAENTPSPH PADLQDAGHE
TWTPEDTRGI LEEGRKTGST ASEQCLSLQD LLSKLGRPFR EYELWALCLA CLSALQKHTE
HPACLCLDNV LVAEDGTVLF GPPPANGSYN SFFLAPEVAE EKLVTEKASV YCVAAVLWTA
AKFSVPRDQK LALPRRLKTL LLDMARRCAP ERPSAAEAIT VCGSYLLQRG MDSRKILAHL
RVSTCKVHQE EETIGLQNAF SVVELKPCTA PAPKPSPGFL PIGTDTRLTV MPAPVPSPPS
CCEGARELPS AFTSEATHFK PIILAKDTGV PRDQLALSLG STKKLEETSE QLGGKDEGSK
ASQDLSGATS LKTPGQLAPS PELQGESLES VTESMPHSLA QECSCQPDPE PANPQEGATP
VIPISSVLAL PPEQGQDGQV PPATTLPLRP TSANQGPHHP CKPPRNNKAA EPEGPQPVTW
GPIARPADRK LCPSSVDVSS PSQKTASPSL QEAMRLIQEE FAFDGYLDNG LEALIMGEYI
YALKDLTFAT FCGAISEKFC DLYWNEQLLQ NLFKVVNGPS SPSESASEDT GSQLQSSPGS
CATSSKRPSL HGLGKEKPAA ARGNGGPCSP TTLSDIDSDT LSQGNLEVGF RPQKSIKATR
EQQPEAGVDG QGLGLEPATR TSDKDTMGQL GRPKDGTQAV SLGPAEFQSC SPGWSSAFYE
ADCFGADVYN YVRDLGRQKA GGHPEPEAQS PELEQQLIIE KRNYRKTLKF YQKLLQKEKR
NKGSDVKTML SKLRGQLEEM KSKVQFLSLV KKYLQVTYAE RWGLEPCALP VIVNIAAAPC
DTLDFSPLDE SSSLIFYNVN KHPCGGRQKK ARVLQAGTPL GLMAYLYSSD AFLEGYVQQF
LYTFRYFCTP HDFLHFLLDR ISSTLSRAHQ DPTSTFTKIY RRSLCVLQAW VEDCYTVDFT
RNAGLLERLE DFISSKILPL DGSAEHLLGL LEVGTDRRAD GTTRGTDLED PKEAEEDTRP
FNALCKRFSE DGISRKSFPW RLPRGNGLAL PHHKERQYTI ASALPKPCFF EDFYGPYAKA
NEKGPYFLTE YSTHQLFTQL TLLQQELFQK CHPVHFLNSR ALGVMDKSTA IPKTSSSESL
SAKTCSLFLP NYVQDKYLLQ LLRNADDVST WVAAEIVTSH TSKLQVNLLS KFLLIAKSCY
EQRNFATAMQ ILSGLEHLAV RQSPAWRILP AKIAEVMEEL KAVEVFLKSD SLCLMEGRRF
RAQPTLPSAH LLAMHIQQLE TGGFTMTNGA HRWSKLRNIA KVVSQVHAFQ ENPYTFSPDP
KLQAHLKQRI ARFSGADISI LAADNRANFH QIPSEKHSRK IQDKLRRMKA TFQ
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