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Database: UniProt
Entry: H0WBS3_CAVPO
LinkDB: H0WBS3_CAVPO
Original site: H0WBS3_CAVPO 
ID   H0WBS3_CAVPO            Unreviewed;      1213 AA.
AC   H0WBS3;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   25-OCT-2017, entry version 37.
DE   SubName: Full=Transient receptor potential cation channel subfamily M member 4 {ECO:0000313|Ensembl:ENSCPOP00000020440};
GN   Name=TRPM4 {ECO:0000313|Ensembl:ENSCPOP00000020440};
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricomorpha; Caviidae; Cavia.
OX   NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000020440};
RN   [1] {ECO:0000313|Ensembl:ENSCPOP00000020440}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000020440};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSCPOP00000020440}
RP   IDENTIFICATION.
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000020440};
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCPOP00000020440}.
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DR   EMBL; AAKN02046413; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02046414; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02046415; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02046416; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 10141.ENSCPOP00000020440; -.
DR   Ensembl; ENSCPOT00000025772; ENSCPOP00000020440; ENSCPOG00000025709.
DR   eggNOG; KOG3614; Eukaryota.
DR   eggNOG; ENOG410XR5B; LUCA.
DR   GeneTree; ENSGT00760000119127; -.
DR   InParanoid; H0WBS3; -.
DR   OMA; GQAPWSD; -.
DR   OrthoDB; EOG091G017C; -.
DR   TreeFam; TF314204; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   Bgee; ENSCPOG00000025709; -.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0034706; C:sodium channel complex; IEA:Ensembl.
DR   GO; GO:0005227; F:calcium activated cation channel activity; IEA:Ensembl.
DR   GO; GO:0005262; F:calcium channel activity; IEA:Ensembl.
DR   GO; GO:0019722; P:calcium-mediated signaling; IEA:Ensembl.
DR   GO; GO:0002407; P:dendritic cell chemotaxis; IEA:Ensembl.
DR   GO; GO:0086045; P:membrane depolarization during AV node cell action potential; IEA:Ensembl.
DR   GO; GO:0086048; P:membrane depolarization during bundle of His cell action potential; IEA:Ensembl.
DR   GO; GO:0086047; P:membrane depolarization during Purkinje myocyte cell action potential; IEA:Ensembl.
DR   GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IEA:Ensembl.
DR   GO; GO:0008284; P:positive regulation of cell proliferation; IEA:Ensembl.
DR   GO; GO:0016925; P:protein sumoylation; IEA:Ensembl.
DR   GO; GO:0086091; P:regulation of heart rate by cardiac conduction; IEA:Ensembl.
DR   GO; GO:0002724; P:regulation of T cell cytokine production; IEA:Ensembl.
DR   GO; GO:0098911; P:regulation of ventricular cardiac muscle cell action potential; IEA:Ensembl.
DR   GO; GO:0098719; P:sodium ion import across plasma membrane; IEA:Ensembl.
DR   GO; GO:0042310; P:vasoconstriction; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR029581; TRPM4.
DR   PANTHER; PTHR13800:SF6; PTHR13800:SF6; 1.
DR   Pfam; PF00520; Ion_trans; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005447};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    691    710       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    778    800       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    888    908       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    928    945       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1013   1046       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      787   1049       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   1213 AA;  135115 MW;  4A405B34ED03E742 CRC64;
     MVAPEKEQSW IPKIFRKKIC TTFIVDLSDP GPRGTLCQCG RPRNAHSSVA VEDAFGAAVV
     TVWDSNVHTT EKPTDAYGEL EFVGAGRRPS NFLRLSDRTD PATIYSLVTR TWGFRAPNLV
     VSVLGGSGGP VLQTWLQDLL RRGLVRAAQS TGAWIVAGGL HTGIGRHVGV AVRDHQTAST
     GGSKVVAMGM APWGVVRNRE TLINPKGSFP AKYRWGDPED GVEFPLDYNY SAFFLDDGTH
     CCAGGEDFRL RFESYVAQQK TGRGRWTGID IPVLLLLIDG DERMLKRIED ATQAQLPCLL
     VAGSGGAADC LAEILEDSLA PGSGGTRRGE ARDRIRRFFP KGDPEVLQAQ VERIMTRKEL
     LTVYASEDGS EEFETIVLKA LVNACRSSEA SAYLDELRLA VAWNRVDIAQ SELFRGDIQW
     RSFHLEASLM DALLNDRPDF VRLLISHGLS LGHFLTPARL AQLYSAAPAH SLIRALLDQA
     AHGVATKSPG PKGGADELRP PQVGQVLRTL LGETCAPKYP TVNARDPHTG KGCRESVSLL
     SDWATSEPSL EASFGQAPWS DLFLWALLLN RAQMAMYFWE MGSNAVSSAL GACLLLRVMA
     RQEAEAEEAA RRKELAAKFE SMGVDLFGEC YRSNEHRASR LLLRRCPLWG DATCLQLAMQ
     ADSRAFFAQD GVQSLLTQKW WGEMDSTTPT WALVLAFFCP PLIYTNLITF RKPEEEATQR
     TPDIGMDTGI NGEGPFGEDQ HSGQKGERSE QMLRAGLKGK VGCVVFDQIW RSFWGSPVTA
     FLGNVVSYLL FLLLFARVLL LDFQPGSPCA WELLLYFWAF TLLCEELRQG LGGGWGSLAS
     GGPRPGHIPL RHHLQRYLAD TWNQCDLLAL TCFLLGVGCR LTMGQYDLGR TVLCIDFMVF
     TLRLLHIFTV NKQLGPKIVI VSKMVKDVFF FLFFLGVWLV AYGVATEGLL RPQDRDLPSI
     LRRVFYRPYL QIFGQIPQED MDVAHMLLTN CSSEEGAWAQ PEGRLAGSCV SQYANWLVVL
     LLIVFLLVAN ILLLNLLIAM FSYTFGKVQG NSDLYWKAQR YSLIREFHSR PALAPPFIVI
     SHVRLLIKRL RRSRRSSIPP SPAFEHFRVR LSKEAERTLL TWESVQKESF LLARARNKRD
     SDTERLKRTS QKWVDTALKQ LGQIREYDQR LKGLEREVHH CSRVLEWVAE ALSRSAMLPP
     GGPPPPSRPG SKG
//
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