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Database: UniProt
Entry: H0WBS3_CAVPO
LinkDB: H0WBS3_CAVPO
Original site: H0WBS3_CAVPO 
ID   H0WBS3_CAVPO            Unreviewed;      1138 AA.
AC   H0WBS3;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 2.
DT   20-DEC-2017, entry version 39.
DE   SubName: Full=Transient receptor potential cation channel subfamily M member 4 {ECO:0000313|Ensembl:ENSCPOP00000020440};
GN   Name=TRPM4 {ECO:0000313|Ensembl:ENSCPOP00000020440};
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricomorpha; Caviidae; Cavia.
OX   NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000020440};
RN   [1] {ECO:0000313|Ensembl:ENSCPOP00000020440}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000020440};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSCPOP00000020440}
RP   IDENTIFICATION.
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000020440};
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCPOP00000020440}.
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DR   EMBL; AAKN02046413; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02046414; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02046415; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAKN02046416; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 10141.ENSCPOP00000020440; -.
DR   Ensembl; ENSCPOT00000025772; ENSCPOP00000020440; ENSCPOG00000025709.
DR   eggNOG; KOG3614; Eukaryota.
DR   eggNOG; ENOG410XR5B; LUCA.
DR   GeneTree; ENSGT00760000119127; -.
DR   InParanoid; H0WBS3; -.
DR   OMA; GQAPWSD; -.
DR   OrthoDB; EOG091G017C; -.
DR   TreeFam; TF314204; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   Bgee; ENSCPOG00000025709; -.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0034706; C:sodium channel complex; IEA:Ensembl.
DR   GO; GO:0005227; F:calcium activated cation channel activity; IEA:Ensembl.
DR   GO; GO:0005262; F:calcium channel activity; IEA:Ensembl.
DR   GO; GO:0019722; P:calcium-mediated signaling; IEA:Ensembl.
DR   GO; GO:0002407; P:dendritic cell chemotaxis; IEA:Ensembl.
DR   GO; GO:0086045; P:membrane depolarization during AV node cell action potential; IEA:Ensembl.
DR   GO; GO:0086048; P:membrane depolarization during bundle of His cell action potential; IEA:Ensembl.
DR   GO; GO:0086047; P:membrane depolarization during Purkinje myocyte cell action potential; IEA:Ensembl.
DR   GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IEA:Ensembl.
DR   GO; GO:0008284; P:positive regulation of cell proliferation; IEA:Ensembl.
DR   GO; GO:0016925; P:protein sumoylation; IEA:Ensembl.
DR   GO; GO:0086091; P:regulation of heart rate by cardiac conduction; IEA:Ensembl.
DR   GO; GO:0002724; P:regulation of T cell cytokine production; IEA:Ensembl.
DR   GO; GO:0098911; P:regulation of ventricular cardiac muscle cell action potential; IEA:Ensembl.
DR   GO; GO:0098719; P:sodium ion import across plasma membrane; IEA:Ensembl.
DR   GO; GO:0042310; P:vasoconstriction; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR029581; TRPM4.
DR   PANTHER; PTHR13800:SF6; PTHR13800:SF6; 1.
DR   Pfam; PF00520; Ion_trans; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005447};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    645    664       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    704    727       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    815    835       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    855    872       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    940    973       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      714    976       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED     1059   1079       {ECO:0000256|SAM:Coils}.
FT   COILED     1083   1103       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1138 AA;  126657 MW;  5BAEA24D4270CEF0 CRC64;
     MVPFIPPPPC SNPQRLGGTL CQCGRPRNAH SSVAVEDAFG AAVVTVWDSN VHTTEKPTDA
     YGELEFVGAG RRPSNFLRLS DRTDPATIYS LVTRTWGFRA PNLVVSVLGG SGGPVLQTWL
     QDLLRRGLVR AAQSTGAWIV AGGLHTGIGR HVGVAVRDHQ TASTGGSKVV AMGMAPWGVV
     RNRETLINPK GSFPDGVEFP LDYNYSAFFL SYVAQQKTGR TGIDIPVLLL LIDGDERMLK
     RIEDATQAQL PCLLVAGSGG AADCLAEILE DSLAPGSGGT RRGEARDRIR RFFPKGDPEV
     LQAQVERIMT RKELLTVYAS EDGSEEFETI VLKALVNACR SSEASAYLDE LRLAVAWNRV
     DIAQSELFRG DIQWRSFHLE ASLMDALLND RPDFVRLLIS HGLSLGHFLT PARLAQLYSA
     APAHSLIRAL LDQAAHGVAT KSPGPKGGAD ELRPPQVGQV LRTLLGETCA PKYPTVNARD
     PHTGKGCRES VSLLSDWATS EPSLEASFGQ APWSDLFLWA LLLNRAQMAM YFWEMGSNAV
     SSALGACLLL RVMARQEAEA EEAARRKELA AKFESMGVDL FGECYRSNEH RASRLLLRRC
     PLWGDATCLQ LAMQADSRAF FAQDGVQSLL TQKWWGEMDS TTPTWALVLA FFCPPLIYTN
     LITFRKPEEE ATQRTPDIGM DTGINGEGPF GERRGIWRRT LERWVTAFLG NVVSYLLFLL
     LFARVLLLDF QPGSPCAWEL LLYFWAFTLL CEELRQGLGG GWGSLASGGP RPGHIPLRHH
     LQRYLADTWN QCDLLALTCF LLGVGCRLTM GQYDLGRTVL CIDFMVFTLR LLHIFTVNKQ
     LGPKIVIVSK MVKDVFFFLF FLGVWLVAYG VATEGLLRPQ DRDLPSILRR VFYRPYLQIF
     GQIPQEDMDV AHMLLTNCSS EEGAWAQPEG RLAGSCVSQY ANWLVVLLLI VFLLVANILL
     LNLLIAMFSY TFGKVQGNSD LYWKAQRYSL IREFHSRPAL APPFIVISHV RLLIKRLRRS
     RRSSIPPSPA FEHFRVRLSK EAERTLLTWE SVQKESFLLA RARNKRDSDT ERLKRTSQKV
     DTALKQLGQI REYDQRLKGL EREVHHCSRV LEWVAEALSR SAMLPPGGPP PPSRPGSK
//
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