ID H0WCQ4_CAVPO Unreviewed; 188 AA.
AC H0WCQ4;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=FRAT regulator of WNT signaling pathway 2 {ECO:0000313|Ensembl:ENSCPOP00000020775.2};
GN Name=FRAT2 {ECO:0000313|Ensembl:ENSCPOP00000020775.2};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000020775.2, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000020775.2}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000020775.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the GSK-3-binding protein family.
CC {ECO:0000256|ARBA:ARBA00010422}.
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DR EMBL; AAKN02002748; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0WCQ4; -.
DR STRING; 10141.ENSCPOP00000020775; -.
DR Ensembl; ENSCPOT00000000140.3; ENSCPOP00000020775.2; ENSCPOG00000000139.4.
DR VEuPathDB; HostDB:ENSCPOG00000000139; -.
DR GeneTree; ENSGT00390000007081; -.
DR HOGENOM; CLU_101225_1_0_1; -.
DR InParanoid; H0WCQ4; -.
DR OMA; TKQLCGR; -.
DR TreeFam; TF330804; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000000139; Expressed in testis and 9 other cell types or tissues.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:Ensembl.
DR InterPro; IPR008014; GSK3-bd.
DR PANTHER; PTHR35154; GBP PROTEIN; 1.
DR PANTHER; PTHR35154:SF3; GBP PROTEIN; 1.
DR Pfam; PF05350; GSK-3_bind; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT REGION 1..97
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 158..188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 56..76
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 188 AA; 20105 MW; 0AE1CD4B002C5D0A CRC64;
MPCRREEEEE AEGEEEEGSF LLLEQTVTLG GSGEVDRLGG PDRQDAAVWT RHPTARPSPG
APPGPPLQPP RPPAASLRLP RVSAEAGSRH PGVLPRPCRR EWLQGSVASR RLQQRRWTHA
AARAGSDDDP HRLLQQLVLS GNLIKEAVRR LQRAVAAVAA TSPVGTPGPD SASSGPERVA
LQTSGNVL
//
