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Database: UniProt
Entry: H0WCV0_CAVPO
LinkDB: H0WCV0_CAVPO
Original site: H0WCV0_CAVPO 
ID   H0WCV0_CAVPO            Unreviewed;       358 AA.
AC   H0WCV0;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 2.
DT   24-JAN-2024, entry version 59.
DE   SubName: Full=G protein-coupled receptor 62 {ECO:0000313|Ensembl:ENSCPOP00000020821.2};
GN   Name=GPR62 {ECO:0000313|Ensembl:ENSCPOP00000020821.2};
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC   Cavia.
OX   NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000020821.2, ECO:0000313|Proteomes:UP000005447};
RN   [1] {ECO:0000313|Proteomes:UP000005447}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA   Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA   Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA   Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA   Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA   Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA   Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA   Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA   Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA   Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA   Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA   Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA   Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA   Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA   Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSCPOP00000020821.2}
RP   IDENTIFICATION.
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000020821.2};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; AAKN02012956; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_003476521.1; XM_003476473.3.
DR   AlphaFoldDB; H0WCV0; -.
DR   STRING; 10141.ENSCPOP00000020821; -.
DR   Ensembl; ENSCPOT00000022608.2; ENSCPOP00000020821.2; ENSCPOG00000023691.2.
DR   GeneID; 100713769; -.
DR   KEGG; cpoc:100713769; -.
DR   CTD; 118442; -.
DR   VEuPathDB; HostDB:ENSCPOG00000023691; -.
DR   eggNOG; KOG3656; Eukaryota.
DR   GeneTree; ENSGT00950000182998; -.
DR   HOGENOM; CLU_067115_0_0_1; -.
DR   InParanoid; H0WCV0; -.
DR   OMA; HCSLYWS; -.
DR   OrthoDB; 4640465at2759; -.
DR   TreeFam; TF332667; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   Bgee; ENSCPOG00000023691; Expressed in hypothalamus and 2 other cell types or tissues.
DR   GO; GO:0005768; C:endosome; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0043235; C:receptor complex; IEA:Ensembl.
DR   GO; GO:1990763; F:arrestin family protein binding; IEA:Ensembl.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0038035; P:G protein-coupled receptor signaling in absence of ligand; IEA:Ensembl.
DR   GO; GO:0050850; P:positive regulation of calcium-mediated signaling; IEA:Ensembl.
DR   GO; GO:0043950; P:positive regulation of cAMP-mediated signaling; IEA:Ensembl.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   PANTHER; PTHR22752; G PROTEIN-COUPLED RECEPTOR; 1.
DR   PANTHER; PTHR22752:SF11; G-PROTEIN COUPLED RECEPTOR 62; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   DOMAIN          31..290
FT                   /note="G-protein coupled receptors family 1 profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50262"
FT   REGION          320..358
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   358 AA;  36741 MW;  257C213C35333352 CRC64;
     MANTTGLIAA EVAGSVGLIL AVLVEVGALL GNGALLVVVL RTPGLQDTLY LVHLCVVDLL
     AAASIMPLSL LAAPPPGLGR VRLGPGPCRA ARFLSAALLP ACTLGVAALG LARYRLIAYP
     LRPGGRPAPG LVLTAVWAAA GLLGALSLLG PPPAPPPAPA RCSVLVGGLK PFRPLWALLA
     FALPALLLLG AYGSIFLVAR RAALRPPLPM RGTRLRSDSL DSRLSFLPTL RPRLPGGKAA
     LAPGLAVGQF AACWLPYGCA CLAPAAQAAE AEAAVTWVAY SAFAAHPFLY GLLQRPVRLA
     LGRLTRRALP RVPKAWHPRA LLQRLKGPPE GPALGPSEAR QQAGGFAGGP SLSLPETT
//
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