ID H0WDS3_CAVPO Unreviewed; 566 AA.
AC H0WDS3;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=Coiled-coil domain-containing protein 22 {ECO:0000256|ARBA:ARBA00016694};
GN Name=CCDC22 {ECO:0000313|Ensembl:ENSCPOP00000021146.2};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000021146.2, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000021146.2}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000021146.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the CCDC22 family.
CC {ECO:0000256|ARBA:ARBA00006438}.
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DR EMBL; AAKN02053555; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02053556; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0WDS3; -.
DR STRING; 10141.ENSCPOP00000021146; -.
DR Ensembl; ENSCPOT00000020899.2; ENSCPOP00000021146.2; ENSCPOG00000024536.2.
DR VEuPathDB; HostDB:ENSCPOG00000024536; -.
DR eggNOG; KOG1937; Eukaryota.
DR GeneTree; ENSGT00390000003809; -.
DR HOGENOM; CLU_024231_1_0_1; -.
DR InParanoid; H0WDS3; -.
DR OMA; KFEQHIQ; -.
DR TreeFam; TF325575; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000024536; Expressed in thyroid gland and 11 other cell types or tissues.
DR GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR GO; GO:0097602; F:cullin family protein binding; IEA:Ensembl.
DR GO; GO:0032456; P:endocytic recycling; IEA:Ensembl.
DR GO; GO:0006893; P:Golgi to plasma membrane transport; IEA:Ensembl.
DR GO; GO:0006878; P:intracellular copper ion homeostasis; IEA:Ensembl.
DR GO; GO:0043124; P:negative regulation of canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:2000060; P:positive regulation of ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR InterPro; IPR008530; CCDC22.
DR InterPro; IPR048348; CCDC22_CC.
DR InterPro; IPR048349; CCDC22_N.
DR PANTHER; PTHR15668:SF4; COILED-COIL DOMAIN-CONTAINING PROTEIN 22; 1.
DR PANTHER; PTHR15668; JM1 PROTEIN; 1.
DR Pfam; PF05667; CCDC22_CC; 2.
DR Pfam; PF21674; CCDC22_N; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT DOMAIN 1..109
FT /note="CCDC22 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF21674"
FT DOMAIN 128..302
FT /note="CCDC22 coiled-coil"
FT /evidence="ECO:0000259|Pfam:PF05667"
FT DOMAIN 304..536
FT /note="CCDC22 coiled-coil"
FT /evidence="ECO:0000259|Pfam:PF05667"
FT REGION 216..246
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 389..463
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 219..246
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 566 AA; 63926 MW; 95245B2C0AA42848 CRC64;
MEEADRILIH SLRQAGTAVP PDVQTLRAFT TELVVEAVVR CLRVINPAVG SGLSPLLPVA
MSARFRLAMS LAQACMDLGY PLELGYQNFL YPSEPDLRDL LLFLAERLPT DTSEDADQPA
GDLAILFRAI GSQIRDQLTL PWVPPLLRTP KLQHFQGSAF QHPFHASSLV MPELSSRGEP
REFQASPLLL PVPMQVAVPA GRVASLLENH AMQLSQHVGR DRPGDDDWLR RAPRLPTQED
PRAPRQRLQK QLAEYLRQSW GPAGTSTQAR DLGELLQAWG AGARTSAPKG SRFTHSEKFT
FHLVENECRQ SELSTAEREQ ALRLKSRAVE LLPDGAANLA KLQLVVESSA QRVIHLAGQW
EKHRVPLLAE YRHLRKLQDC RELESSRRLA EIQELHQSVR AAAEEARRKE EVYKQLVSEL
ETLPRDVSRL AYTQRILEIV GNIRKQKEEI TKILSDTKEL QKEINSLSGK LDRTFAVTDE
LVFKDAKKDD AVRKAYKYLA ALHENCSQLI QTIEDTGTIM REVRDLEEQI ETEMSKKTLS
NLEKICEDYR ALRQENAGLL GRVREA
//
