ID H0WFW3_OTOGA Unreviewed; 2642 AA.
AC H0WFW3;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=Serine/threonine-protein kinase ATR {ECO:0000256|ARBA:ARBA00024420};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=ATR {ECO:0000313|Ensembl:ENSOGAP00000000152.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000000152.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000000152.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. ATM subfamily.
CC {ECO:0000256|ARBA:ARBA00010769}.
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DR EMBL; AAQR03062771; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03062772; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03062773; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03062774; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03062775; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03062776; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03062777; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03062778; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03062779; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03062780; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 30611.ENSOGAP00000000152; -.
DR Ensembl; ENSOGAT00000000171.2; ENSOGAP00000000152.2; ENSOGAG00000000171.2.
DR eggNOG; KOG0890; Eukaryota.
DR GeneTree; ENSGT00940000155714; -.
DR HOGENOM; CLU_000178_2_1_1; -.
DR InParanoid; H0WFW3; -.
DR OMA; SMYIGWC; -.
DR TreeFam; TF101183; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0070310; C:ATR-ATRIP complex; IEA:Ensembl.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0005635; C:nuclear envelope; IEA:Ensembl.
DR GO; GO:0016605; C:PML body; IEA:Ensembl.
DR GO; GO:0090734; C:site of DNA damage; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0035979; F:histone H2AXS139 kinase activity; IEA:Ensembl.
DR GO; GO:0032405; F:MutLalpha complex binding; IEA:Ensembl.
DR GO; GO:0032407; F:MutSalpha complex binding; IEA:Ensembl.
DR GO; GO:0071480; P:cellular response to gamma radiation; IEA:Ensembl.
DR GO; GO:0034644; P:cellular response to UV; IEA:Ensembl.
DR GO; GO:0000077; P:DNA damage checkpoint signaling; IEA:Ensembl.
DR GO; GO:0006302; P:double-strand break repair; IEA:Ensembl.
DR GO; GO:0097694; P:establishment of RNA localization to telomere; IEA:Ensembl.
DR GO; GO:0008156; P:negative regulation of DNA replication; IEA:Ensembl.
DR GO; GO:0051081; P:nuclear membrane disassembly; IEA:Ensembl.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0043517; P:positive regulation of DNA damage response, signal transduction by p53 class mediator; IEA:Ensembl.
DR GO; GO:1904884; P:positive regulation of telomerase catalytic core complex assembly; IEA:Ensembl.
DR GO; GO:0070198; P:protein localization to chromosome, telomeric region; IEA:Ensembl.
DR GO; GO:0090399; P:replicative senescence; IEA:Ensembl.
DR GO; GO:0009612; P:response to mechanical stimulus; IEA:Ensembl.
DR CDD; cd00892; PIKKc_ATR; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR012993; UME.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF128; SERINE_THREONINE-PROTEIN KINASE ATR; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF08064; UME; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SMART; SM00802; UME; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00023204};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1641..2186
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 2294..2602
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 2610..2642
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
SQ SEQUENCE 2642 AA; 300831 MW; D770DB15B520186C CRC64;
MGEHGLELAS MIPALRELGS AAPEDYNTVV QKPRQILCQF IDRILTDVNV VALELIKKTD
SQPTSVMLLD FIQHIMKSSP LMFVNVNGSH GQNEAKSSCI EFSNWIITRL LRIAATPSCH
MLHKKICEVI CSLLFLFKSK SPSIFGVLTK ELLHLFEDLI YLHRRNAVGH VEWPVVVTRF
LSQLDEHMEY LQPAPLQFMS MQNLEFIEVT LLTVLIRIIA IVFFRRQELL LWQIGCVLLE
YGSPKIKSLA MSLLTKLFEL GGLPAQPAST FFSSFLGLLK SLVEVDTDQL KLYEEPLSKL
IKTLFPFEAE AYRNIEPVYL NMLLERLCVI FEDGVLMRLK SDLLKAALCH ILQYFLKFVP
AGYESALHVR KGYVRNICRA LVDVLGIQVD AGYLLGPLYA ALKIESMEII EEIECQTQQE
NLSSNIDGIS PKRRRLSSSL NSLKRASKQT EEIKHVDMSK KSILWSALKQ KAESLQISLE
CSSLKNPVIE TLEGIAVVLQ LTALCTIHCS HQNVACHNFK DFEHKSKKKL SIVITWMPLD
FYTRVLKSCR SLLESIQKPD LEAIIDNVVK IYDALIYMQV KSSFEDHILE ELCGMLSIPW
IYSHSDDCLK LTTFATGLLT LSQRISDSYS PQAQSRCVFL LTLLPRGIFL EWRTAVYNWA
LQSSYEVIRA SCVNGFFILL QQQNSCNRVP KILIDKVKDD SDIVKKEFAS ILGQLVCTLH
GMFYLTSSLI EPFSEHGHVD LFCKNLKATS QHECSSSRLK ASICKPFLFL LKKNTPSPVK
LAFIDNLPHL CKHLDFREDE TDVKAVLGTL LNLMEDPDKD VRVAFSGNIK HVLGSLDSED
GFIKELFVLR MKEAYTHAQI SRNNELKDTL ILTTGDIGRA AKGDLVPFAL LHLLHCLLSK
SASVSGAAYT EIRALVAAKS VKLQNFFSQY KKPICQFLVE SLHSSQMAAL PSTPFQNAEI
RKQDVAHQRE MALNTLSEIA NVFDFPDLNR FLTRTLQVLL PDLAAKASPA ASALIRTLGK
QLNVNRREIL INNFKYIFSH LVCSCSKDEL ERALHYLKNE TEIELGSLLR QDFQGLHNEL
LLRIGEHYQQ VFNGLSILAS FASSDDPYQG PRDITSPELM ANYLQPKLLG ILAFFNMQLL
SSSVGIEDKK MALNSLMSLM KLMGPKHVSS VRVKMMTTLR TGLRFKDDFP ELCCRAWDCF
VRCLDHACLG SLLSHVIVAL LPLIHIQPKE TAAIFHYLII ENRDAVQDFL HEIYFLPDHP
ELKKIKAVLQ EYRKETSEST DLQTTLQLSM KAIQHENVDV RIHALTSLKE TLYKNQEELI
KYATDSETVE PIISQLVTVL LKGCQDANSQ ARLLCGECLG ELGAIDPGRL DFSTTETQGK
DFTFVTGVED LTFAYGLLME LTRAYLAYAD NSRAQDSAAY AIQELLSIYE CREMETDGPG
HQLWKRFPEH VREILEPHLN TRYKSSQKST DWSGVKKPIY LSELGNNFAE WSASWAGYLI
TKVRHELASK IFTCCSIMMK HDFKVTIYLL PHILVYVLLG CNQEDQQEVY AEIMAVLKHD
DQHTISTQDS ASDLCQLSTQ TVFSMLDHLA QWARHKFQAL NAEKFAQSKS NRDKVNSMVA
SADHEDYQSV TRFLDLIPQD TLAVASFRSR AYTRAVMHFE SFITEKKQNI QEHLGFLQKL
YAAMHEPDGV AGVSTIRKAE PSLKEQILEH ESIGLLRDAT ACYDRAIQLE PDQIIHYHGV
VKSMLGLGQL STVITQVNGV HANRSEWTDE LNTYRVEAAW KLSQWDLVES YLAEDGKSTT
WSVRLGQLLL SAKKRDITAF YNTLKLVRTE QIVPLSAASF ERGSYQRGYE YIVRLHMLCE
LEHSTKPLFH QSPGDSSQED SLNWVARLEM TQNSYRAKEP ILALRRALLS LNKRPDYNEM
VGECWLQSAR VARKAGHHQT AYNAILNAGE SRLAELYVEK AKWLWSKGDV HQALMVLQKG
VELCFPENKT PTDNKNMLIH GRATLLVGRF MEETANFESN AIMKKYKDVT VVLPEWEDGH
FYLAKYYDKL MPMVTDNKME KQGDLIRYIV LHFGRSLQYG NQFIYQSMPR MLSLWLDFGS
KAYECEKACR CDRIQMRNDL GKINKVITEH TNYLAPYQFL TAFSQLISRI CHSHDEVFVV
LMEIIAKVFL AYPQQAMWMM TAVSKSSYPM RVNRCKEILN KAIEMKKSLE KFVGDATRLT
DKLLELCNKS VDGNSSTLSM STHFKMLKKL VEESTFSEIL IPLQSVMIPT LPSVLGAHAN
HDPFPGHWAY IAGFDDTVEI LASLQKPKKI SLKGSDGKFY IMMCKPKDDL RKDCRLMEFN
SLINKCLRKD AESRRRELHI RTYAVIPLND ECGIIEWVNN TAGLRPILTK LYKERGVYMT
GKELRQCMLP KAAALSEKLK IFREFLLPRH PPVFHEWFLR TFPDPTSWYS SRSAYCRSTA
VMSMVGYILG LGDRHGENIL FDSLTGECVH VDFNCLFNKG ETFEVPEIVP FRLTHNMVNG
MGPMGTEGLF RRACEVTLRL MRDQSEPLMS VLKTFLHDPL VEWSKPVKGH SKAQLNETGE
VVNEKAKTHV LDIEQRLQGI IKTRNRVTGL PLSIEGHVHY LIQEATDENL LCQMYLGWTP
YM
//
