ID   H0WIX4_OTOGA            Unreviewed;       627 AA.
AC   H0WIX4;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   27-MAR-2024, entry version 63.
DE   SubName: Full=Kelch repeat and BTB domain containing 2 {ECO:0000313|Ensembl:ENSOGAP00000001410.2};
GN   Name=KBTBD2 {ECO:0000313|Ensembl:ENSOGAP00000001410.2};
OS   Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC   Galagidae; Otolemur.
OX   NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000001410.2, ECO:0000313|Proteomes:UP000005225};
RN   [1] {ECO:0000313|Proteomes:UP000005225}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA   Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA   Walker B.J., Sharpe T., Hall G.;
RT   "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL   Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSOGAP00000001410.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; AAQR03057695; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03057696; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03057697; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; H0WIX4; -.
DR   STRING; 30611.ENSOGAP00000001410; -.
DR   Ensembl; ENSOGAT00000001586.2; ENSOGAP00000001410.2; ENSOGAG00000001585.2.
DR   eggNOG; KOG4441; Eukaryota.
DR   GeneTree; ENSGT00940000156069; -.
DR   HOGENOM; CLU_004253_14_5_1; -.
DR   InParanoid; H0WIX4; -.
DR   OMA; CEKDEWT; -.
DR   TreeFam; TF332672; -.
DR   Proteomes; UP000005225; Unassembled WGS sequence.
DR   GO; GO:0010467; P:gene expression; IEA:Ensembl.
DR   GO; GO:0006006; P:glucose metabolic process; IEA:Ensembl.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:Ensembl.
DR   GO; GO:0043491; P:phosphatidylinositol 3-kinase/protein kinase B signal transduction; IEA:Ensembl.
DR   GO; GO:0032868; P:response to insulin; IEA:Ensembl.
DR   CDD; cd18479; BACK_KBTBD2; 1.
DR   CDD; cd18270; BTB_POZ_KBTBD2_BKLHD1; 1.
DR   Gene3D; 1.25.40.420; -; 1.
DR   Gene3D; 2.120.10.80; Kelch-type beta propeller; 1.
DR   InterPro; IPR011705; BACK.
DR   InterPro; IPR017096; BTB-kelch_protein.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR030586; BTB_POZ_KBTBD2.
DR   InterPro; IPR047074; KBTBD2_BACK.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR006652; Kelch_1.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   PANTHER; PTHR24412; KELCH PROTEIN; 1.
DR   PANTHER; PTHR24412:SF192; KELCH REPEAT AND BTB DOMAIN-CONTAINING PROTEIN 2; 1.
DR   Pfam; PF07707; BACK; 1.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF01344; Kelch_1; 1.
DR   PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR   SMART; SM00875; BACK; 1.
DR   SMART; SM00225; BTB; 1.
DR   SMART; SM00612; Kelch; 4.
DR   SUPFAM; SSF117281; Kelch motif; 1.
DR   SUPFAM; SSF54695; POZ domain; 1.
DR   PROSITE; PS50097; BTB; 1.
PE   4: Predicted;
KW   Kelch repeat {ECO:0000256|ARBA:ARBA00022441};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          35..102
FT                   /note="BTB"
FT                   /evidence="ECO:0000259|PROSITE:PS50097"
SQ   SEQUENCE   627 AA;  71876 MW;  3B768EB3D12CC93F CRC64;
     WKIVMSTQDE RQINTEYAVS LLEQLKLFYE QQLFTDIVLI VEGTEFPCHK MVLATCSSYF
     RAMFMSGLSE SKQTHVHLRN VDAATLQIII TYAYTGNLAV NDRTVEQLYE TACFLQVEDV
     LQRCREYLIK KINAENCVRL LSFADLFSCE ELKQSAKRMV EHKFTAVYHQ EAFMQLSHDL
     LIDILSSDNL NVEKEETVRE AAMLWLEYNT ESRSQYLSSV LSQIRIDALS EVTQRAWFQG
     LPPNDKSVVV QGLYKSMPKF FKPRLGMTKE EMMIFIEASS ENPCSLYSSV CYSPQAEKVY
     KLCSPPADLH KVGTVVTPDN DIYIAGGQIP LKNTKTNHSK TSKLQTAFRT VNCFYWFDAQ
     QNTWFPKTPM LFVRVKPSLV CCEGYIYAIG GDSVGGELNR RTVERYDTEK DEWTMVSPLP
     CAWQWSAAVV VHDCIYVMTL NLMYCYFPRS DSWVEMAMRQ TSRSFASAAA FGDKIFYIGG
     LHIATNSGIR LPSGTVDGSS VTVEIYDVNK NEWKMAANIP AKRYSDPCVR AVVISNSLCV
     FMRETHLNER AKYVTYQYDL ELDRWSLRQH ISERVLWDLG RDFRCTVGKL YPSCLEESPW
     KPPTYLFSPD GTDDFELDGE MVALPPV
//