ID H0WIY3_OTOGA Unreviewed; 367 AA.
AC H0WIY3;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=choline-phosphate cytidylyltransferase {ECO:0000256|ARBA:ARBA00026101};
DE EC=2.7.7.15 {ECO:0000256|ARBA:ARBA00026101};
GN Name=PCYT1A {ECO:0000313|Ensembl:ENSOGAP00000001420.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000001420.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000001420.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Catalyzes the key rate-limiting step in the CDP-choline
CC pathway for phosphatidylcholine biosynthesis.
CC {ECO:0000256|ARBA:ARBA00025501}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=CTP + H(+) + phosphocholine = CDP-choline + diphosphate;
CC Xref=Rhea:RHEA:18997, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:37563, ChEBI:CHEBI:58779, ChEBI:CHEBI:295975;
CC EC=2.7.7.15; Evidence={ECO:0000256|ARBA:ARBA00024554};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:18998;
CC Evidence={ECO:0000256|ARBA:ARBA00024554};
CC -!- PATHWAY: Phospholipid metabolism; phosphatidylcholine biosynthesis;
CC phosphatidylcholine from phosphocholine: step 1/2.
CC {ECO:0000256|ARBA:ARBA00025706}.
CC -!- SIMILARITY: Belongs to the cytidylyltransferase family.
CC {ECO:0000256|ARBA:ARBA00010101}.
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DR EMBL; AAQR03094147; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03094148; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03094149; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03094150; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03094151; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03094152; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03094153; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003792712.1; XM_003792664.2.
DR AlphaFoldDB; H0WIY3; -.
DR STRING; 30611.ENSOGAP00000001420; -.
DR Ensembl; ENSOGAT00000001597.2; ENSOGAP00000001420.2; ENSOGAG00000001596.2.
DR GeneID; 100964062; -.
DR KEGG; oga:100964062; -.
DR CTD; 5130; -.
DR eggNOG; KOG2804; Eukaryota.
DR GeneTree; ENSGT00940000157384; -.
DR HOGENOM; CLU_034585_4_2_1; -.
DR InParanoid; H0WIY3; -.
DR OMA; IWRESKG; -.
DR OrthoDB; 5474784at2759; -.
DR TreeFam; TF106336; -.
DR UniPathway; UPA00753; UER00739.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:Ensembl.
DR GO; GO:0042587; C:glycogen granule; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0004105; F:choline-phosphate cytidylyltransferase activity; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR CDD; cd02174; CCT; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR InterPro; IPR041723; CCT.
DR InterPro; IPR004821; Cyt_trans-like.
DR InterPro; IPR045049; Pcy1-like.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR NCBIfam; TIGR00125; cyt_tran_rel; 1.
DR PANTHER; PTHR10739:SF19; CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE A; 1.
DR PANTHER; PTHR10739; CYTIDYLYLTRANSFERASE; 1.
DR Pfam; PF01467; CTP_transf_like; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Phospholipid biosynthesis {ECO:0000256|ARBA:ARBA00023209};
KW Phospholipid metabolism {ECO:0000256|ARBA:ARBA00023264};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225}.
FT DOMAIN 80..208
FT /note="Cytidyltransferase-like"
FT /evidence="ECO:0000259|Pfam:PF01467"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 313..367
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 239..266
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 7..22
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 314..350
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 367 AA; 41720 MW; AC1EDA404E0A3E55 CRC64;
MDAQSSAKVN ARKRRKEAPG PNGATEEDGI PSKVQRCAVG LRQPAPFSDE IEVDLSKPYV
RVTMEEARRG TPCERPVRVY ADGIFDLFHS GHARALMQAK NLFPNTYLIV GVCSDELTHN
FKGFTVMNEN ERYDAVQHCR YVDEVVRNAP WTLTPEFLAE HQIDFVAHDD IPYSSAGSDD
VYKHIKEAGM FAPTQRTEGI STSDIITRIV RDYDVYARRN LQRGYTAKEL NVSFINEKKY
HLQERVDKVK KKVKDVEEKS KEFVQKVEEK SIDLIQKWEE KSREFIGSFL EMFGPEGALK
HMLKEGKGRM LQAISPKQSP SSSPTRERSP SPSFRWPFSG KTSPPSSPAN LSRHKAAAYD
ISEDEED
//
