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Database: UniProt
Entry: H0WJ02_OTOGA
LinkDB: H0WJ02_OTOGA
Original site: H0WJ02_OTOGA 
ID   H0WJ02_OTOGA            Unreviewed;      1436 AA.
AC   H0WJ02;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   24-JAN-2024, entry version 79.
DE   RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE            EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN   Name=YTHDC2 {ECO:0000313|Ensembl:ENSOGAP00000001441.2};
OS   Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC   Galagidae; Otolemur.
OX   NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000001441.2, ECO:0000313|Proteomes:UP000005225};
RN   [1] {ECO:0000313|Proteomes:UP000005225}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA   Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA   Walker B.J., Sharpe T., Hall G.;
RT   "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL   Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSOGAP00000001441.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC         Evidence={ECO:0000256|ARBA:ARBA00001556};
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DR   EMBL; AAQR03059537; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03059538; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03059539; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03059540; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03059541; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03059542; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03059543; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03059544; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_003788959.1; XM_003788911.1.
DR   SMR; H0WJ02; -.
DR   STRING; 30611.ENSOGAP00000001441; -.
DR   Ensembl; ENSOGAT00000001619.2; ENSOGAP00000001441.2; ENSOGAG00000001618.2.
DR   GeneID; 100948403; -.
DR   KEGG; oga:100948403; -.
DR   CTD; 64848; -.
DR   eggNOG; KOG0920; Eukaryota.
DR   eggNOG; KOG0922; Eukaryota.
DR   eggNOG; KOG1902; Eukaryota.
DR   GeneTree; ENSGT00940000155826; -.
DR   HOGENOM; CLU_001832_1_6_1; -.
DR   InParanoid; H0WJ02; -.
DR   OMA; CATQRAG; -.
DR   OrthoDB; 1095660at2759; -.
DR   TreeFam; TF318311; -.
DR   Proteomes; UP000005225; Unassembled WGS sequence.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0035770; C:ribonucleoprotein granule; IEA:Ensembl.
DR   GO; GO:0034458; F:3'-5' RNA helicase activity; IEA:Ensembl.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:1990247; F:N6-methyladenosine-containing RNA reader activity; IEA:Ensembl.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0070063; F:RNA polymerase binding; IEA:Ensembl.
DR   GO; GO:0051729; P:germline cell cycle switching, mitotic to meiotic cell cycle; IEA:Ensembl.
DR   GO; GO:0048599; P:oocyte development; IEA:Ensembl.
DR   GO; GO:0044829; P:positive regulation by host of viral genome replication; IEA:Ensembl.
DR   GO; GO:0070555; P:response to interleukin-1; IEA:Ensembl.
DR   GO; GO:0034612; P:response to tumor necrosis factor; IEA:Ensembl.
DR   GO; GO:0007286; P:spermatid development; IEA:Ensembl.
DR   CDD; cd17987; DEXHc_YTHDC2; 1.
DR   CDD; cd06007; R3H_DEXH_helicase; 1.
DR   CDD; cd18791; SF2_C_RHA; 1.
DR   CDD; cd21134; YTH; 1.
DR   Gene3D; 1.20.120.1080; -; 1.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   Gene3D; 3.10.590.10; ph1033 like domains; 1.
DR   Gene3D; 3.30.1370.50; R3H-like domain; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR048333; HA2_WH.
DR   InterPro; IPR007502; Helicase-assoc_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR034083; R3H_DEXH_helicase.
DR   InterPro; IPR001374; R3H_dom.
DR   InterPro; IPR036867; R3H_dom_sf.
DR   InterPro; IPR007275; YTH_domain.
DR   PANTHER; PTHR18934:SF213; 3'-5' RNA HELICASE YTHDC2; 1.
DR   PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF21010; HA2_C; 1.
DR   Pfam; PF04408; HA2_N; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF07717; OB_NTP_bind; 1.
DR   Pfam; PF01424; R3H; 1.
DR   Pfam; PF04146; YTH; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00847; HA2; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SMART; SM00393; R3H; 1.
DR   SUPFAM; SSF48403; Ankyrin repeat; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   SUPFAM; SSF82708; R3H domain; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51061; R3H; 1.
DR   PROSITE; PS50882; YTH; 1.
PE   4: Predicted;
KW   ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT   DOMAIN          44..112
FT                   /note="R3H"
FT                   /evidence="ECO:0000259|PROSITE:PS51061"
FT   DOMAIN          209..375
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   REPEAT          512..544
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   DOMAIN          618..790
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
FT   DOMAIN          1294..1424
FT                   /note="YTH"
FT                   /evidence="ECO:0000259|PROSITE:PS50882"
FT   REGION          1..40
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1170..1294
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1170..1184
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1194..1208
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1238..1258
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1436 AA;  160695 MW;  2B9E2787A786C713 CRC64;
     MSRPSSVSPR PPAPGGGGGG SGGGGGGPAP CGPGGGGRAK GLKDIRIDEE VKIAVNIALE
     RFRYGEQREM EFPSSLTSTE RAFIHRLSQS LGLVSKSKGK GANRYLTVKK KDGSETAHAM
     MTCNLTHNTK HAVRSLIQRF PVTNKERTEL LPKTERGNVF AVEAENREMS KTSGRLNNGI
     PQIPVKRGES EFDSFRQSLP VFEKQEEIVK IIKENKVVLI VGETGSGKTT QIPQFLLDDC
     FKNGIPCRIF CTQPRRLAAI AVAERVAAER RERIGQTIGY QIRLESRVSP KTLLTFCTNG
     VLLRTLMAGD STLSTVTHVI VDEVHERDRF SDFLLTKLRD LLQKHPTLKL ILSSAALDVN
     LFIRYFGSCP VIYIQGRPFE VKEMFLEDIL RTTGYTNKEM LKYKKEKQRE EKQQTTLTEW
     YSAQENTFKP ESQRQRTVPN VTEEYDLLDD GGDAVFSQLT EKDVNCLEPW LIKEMDACLS
     DIWLHKDVDA FAQVFHLILT ENVSVDYRHS ETSATALMVA AGRGFASQVE QLISMGANVH
     SKASNGWMAL DWAKHFGQTE IVDLLESYSA SLEFGNLDES SLVQTNGSDL SAEDRELLKA
     YHHSFDDEKV DLDLIMHLLY NICHSCDAGA ILIFLPGYDE IVGLRDRILF DDKRFADNTH
     RYQVFMLHSN MQTSDQKKVL KNPPAGVRKI ILSTNIAETS ITVNDVVFVI DSGKVKEKSF
     DALNFVTMLK MVWISKASAI QRKGRAGRCR PGICFRLFSR LRFQNMLEFQ TPELLRMPLQ
     ELCLHTKLLA PVNCPIADFL MKAPEPPPAL IVRNAVQMLK TIDAMDAWED LTELGYHLAD
     LPVEPHLGKM VLCAVVLKCL DPILTIACTL AYRDPFVLPT QASQKRAAML CRKRFTAGTF
     SDHMALLRAF QAWQKARSDG WERAFCEKNF LSQATMEIII GMRTQLLGQL RASGFVRARG
     GGDIRDVNTN SENWAVVKAA LVAGMYPNLV HVDRENVVLT GPKEKKVRFH PTSVLSQPQY
     KKIPPANGQA AAIQALPTDW LIYDEMTRAH RIANIRCCSA VTPVTVLVFC GPARLASNAL
     QEPSSFRVDG IPNDSSDSEM EDRTTANLAA LKLDEWLNFK LEPEAASLLL QLRQKWHSLF
     LRRMRAPSKP WSQVDEATIR AIIAVLSTEE QSAGLQQPSG IGQRPRPMSS EELPLASSWR
     SNNSRKSSAD TEFSDESTAA ERVLMKSPSP ALHPPQKYKD RGILHPKRST DDRSDQSSVK
     STDSSSYPSP CASPSPPSSG KGSKSPSPRP NMPIRYFIMK SSNLRNLEIS QQKGIWSTTP
     SNERKLNRAF WESSMVYLVF SVQGSGHFQG FSRMCSEIGR EKSQEWGSAG LGGVFKVEWI
     RKESLPFQFA HHLLNPWNDN KKVQISRDGQ ELEPQVGEQL LQLWERLPLG EKTTTD
//
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