ID H0WJ02_OTOGA Unreviewed; 1436 AA.
AC H0WJ02;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 24-JAN-2024, entry version 79.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN Name=YTHDC2 {ECO:0000313|Ensembl:ENSOGAP00000001441.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000001441.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000001441.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
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DR EMBL; AAQR03059537; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03059538; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03059539; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03059540; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03059541; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03059542; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03059543; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03059544; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003788959.1; XM_003788911.1.
DR SMR; H0WJ02; -.
DR STRING; 30611.ENSOGAP00000001441; -.
DR Ensembl; ENSOGAT00000001619.2; ENSOGAP00000001441.2; ENSOGAG00000001618.2.
DR GeneID; 100948403; -.
DR KEGG; oga:100948403; -.
DR CTD; 64848; -.
DR eggNOG; KOG0920; Eukaryota.
DR eggNOG; KOG0922; Eukaryota.
DR eggNOG; KOG1902; Eukaryota.
DR GeneTree; ENSGT00940000155826; -.
DR HOGENOM; CLU_001832_1_6_1; -.
DR InParanoid; H0WJ02; -.
DR OMA; CATQRAG; -.
DR OrthoDB; 1095660at2759; -.
DR TreeFam; TF318311; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0035770; C:ribonucleoprotein granule; IEA:Ensembl.
DR GO; GO:0034458; F:3'-5' RNA helicase activity; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:1990247; F:N6-methyladenosine-containing RNA reader activity; IEA:Ensembl.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0070063; F:RNA polymerase binding; IEA:Ensembl.
DR GO; GO:0051729; P:germline cell cycle switching, mitotic to meiotic cell cycle; IEA:Ensembl.
DR GO; GO:0048599; P:oocyte development; IEA:Ensembl.
DR GO; GO:0044829; P:positive regulation by host of viral genome replication; IEA:Ensembl.
DR GO; GO:0070555; P:response to interleukin-1; IEA:Ensembl.
DR GO; GO:0034612; P:response to tumor necrosis factor; IEA:Ensembl.
DR GO; GO:0007286; P:spermatid development; IEA:Ensembl.
DR CDD; cd17987; DEXHc_YTHDC2; 1.
DR CDD; cd06007; R3H_DEXH_helicase; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR CDD; cd21134; YTH; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.10.590.10; ph1033 like domains; 1.
DR Gene3D; 3.30.1370.50; R3H-like domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR034083; R3H_DEXH_helicase.
DR InterPro; IPR001374; R3H_dom.
DR InterPro; IPR036867; R3H_dom_sf.
DR InterPro; IPR007275; YTH_domain.
DR PANTHER; PTHR18934:SF213; 3'-5' RNA HELICASE YTHDC2; 1.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR Pfam; PF01424; R3H; 1.
DR Pfam; PF04146; YTH; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00393; R3H; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF82708; R3H domain; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS51061; R3H; 1.
DR PROSITE; PS50882; YTH; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT DOMAIN 44..112
FT /note="R3H"
FT /evidence="ECO:0000259|PROSITE:PS51061"
FT DOMAIN 209..375
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT REPEAT 512..544
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 618..790
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 1294..1424
FT /note="YTH"
FT /evidence="ECO:0000259|PROSITE:PS50882"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1170..1294
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1170..1184
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1194..1208
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1238..1258
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1436 AA; 160695 MW; 2B9E2787A786C713 CRC64;
MSRPSSVSPR PPAPGGGGGG SGGGGGGPAP CGPGGGGRAK GLKDIRIDEE VKIAVNIALE
RFRYGEQREM EFPSSLTSTE RAFIHRLSQS LGLVSKSKGK GANRYLTVKK KDGSETAHAM
MTCNLTHNTK HAVRSLIQRF PVTNKERTEL LPKTERGNVF AVEAENREMS KTSGRLNNGI
PQIPVKRGES EFDSFRQSLP VFEKQEEIVK IIKENKVVLI VGETGSGKTT QIPQFLLDDC
FKNGIPCRIF CTQPRRLAAI AVAERVAAER RERIGQTIGY QIRLESRVSP KTLLTFCTNG
VLLRTLMAGD STLSTVTHVI VDEVHERDRF SDFLLTKLRD LLQKHPTLKL ILSSAALDVN
LFIRYFGSCP VIYIQGRPFE VKEMFLEDIL RTTGYTNKEM LKYKKEKQRE EKQQTTLTEW
YSAQENTFKP ESQRQRTVPN VTEEYDLLDD GGDAVFSQLT EKDVNCLEPW LIKEMDACLS
DIWLHKDVDA FAQVFHLILT ENVSVDYRHS ETSATALMVA AGRGFASQVE QLISMGANVH
SKASNGWMAL DWAKHFGQTE IVDLLESYSA SLEFGNLDES SLVQTNGSDL SAEDRELLKA
YHHSFDDEKV DLDLIMHLLY NICHSCDAGA ILIFLPGYDE IVGLRDRILF DDKRFADNTH
RYQVFMLHSN MQTSDQKKVL KNPPAGVRKI ILSTNIAETS ITVNDVVFVI DSGKVKEKSF
DALNFVTMLK MVWISKASAI QRKGRAGRCR PGICFRLFSR LRFQNMLEFQ TPELLRMPLQ
ELCLHTKLLA PVNCPIADFL MKAPEPPPAL IVRNAVQMLK TIDAMDAWED LTELGYHLAD
LPVEPHLGKM VLCAVVLKCL DPILTIACTL AYRDPFVLPT QASQKRAAML CRKRFTAGTF
SDHMALLRAF QAWQKARSDG WERAFCEKNF LSQATMEIII GMRTQLLGQL RASGFVRARG
GGDIRDVNTN SENWAVVKAA LVAGMYPNLV HVDRENVVLT GPKEKKVRFH PTSVLSQPQY
KKIPPANGQA AAIQALPTDW LIYDEMTRAH RIANIRCCSA VTPVTVLVFC GPARLASNAL
QEPSSFRVDG IPNDSSDSEM EDRTTANLAA LKLDEWLNFK LEPEAASLLL QLRQKWHSLF
LRRMRAPSKP WSQVDEATIR AIIAVLSTEE QSAGLQQPSG IGQRPRPMSS EELPLASSWR
SNNSRKSSAD TEFSDESTAA ERVLMKSPSP ALHPPQKYKD RGILHPKRST DDRSDQSSVK
STDSSSYPSP CASPSPPSSG KGSKSPSPRP NMPIRYFIMK SSNLRNLEIS QQKGIWSTTP
SNERKLNRAF WESSMVYLVF SVQGSGHFQG FSRMCSEIGR EKSQEWGSAG LGGVFKVEWI
RKESLPFQFA HHLLNPWNDN KKVQISRDGQ ELEPQVGEQL LQLWERLPLG EKTTTD
//