ID H0WJD9_OTOGA Unreviewed; 1019 AA.
AC H0WJD9;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 84.
DE SubName: Full=Signal peptide, CUB domain and EGF like domain containing 1 {ECO:0000313|Ensembl:ENSOGAP00000001613.2};
GN Name=SCUBE1 {ECO:0000313|Ensembl:ENSOGAP00000001613.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000001613.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000001613.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; AAQR03015813; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0WJD9; -.
DR STRING; 30611.ENSOGAP00000001613; -.
DR Ensembl; ENSOGAT00000001811.2; ENSOGAP00000001613.2; ENSOGAG00000001810.2.
DR eggNOG; KOG1217; Eukaryota.
DR GeneTree; ENSGT00940000153185; -.
DR HOGENOM; CLU_013079_0_0_1; -.
DR InParanoid; H0WJD9; -.
DR OMA; YQDVEGQ; -.
DR OrthoDB; 5477406at2759; -.
DR TreeFam; TF351672; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0045880; P:positive regulation of smoothened signaling pathway; IEA:Ensembl.
DR CDD; cd00041; CUB; 1.
DR CDD; cd00054; EGF_CA; 2.
DR Gene3D; 2.10.25.10; Laminin; 9.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 3.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR PANTHER; PTHR24046; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR24046:SF4; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF07645; EGF_CA; 2.
DR Pfam; PF07699; Ephrin_rec_like; 3.
DR Pfam; PF14670; FXa_inhibition; 3.
DR SMART; SM00042; CUB; 1.
DR SMART; SM00181; EGF; 10.
DR SMART; SM00179; EGF_CA; 7.
DR SMART; SM01411; Ephrin_rec_like; 3.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 5.
DR PROSITE; PS01180; CUB; 1.
DR PROSITE; PS01186; EGF_2; 3.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS01187; EGF_CA; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..1019
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003543941"
FT DOMAIN 33..73
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 353..391
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 829..941
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT REGION 493..512
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 357..367
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1019 AA; 111769 MW; 21EF305E9BB3ED58 CRC64;
MGAAAVRWHL CLLIALGTRG RLAGATGLPG AVDVDECSEG TDDCHIDAIC QNTPKSYKCL
CKPGYKGEGR QCEDIDECEN DHYNGGCVHE CINIPGNYRC TCFDGFMLAH DGHNCLDVDE
CQDNNGGCQQ ICVNAMGSYE CQCHSGFFLS DNQHTCIHRS NEGMNCMNKD HGCAHICRET
PKGGVACDCR PGFDLAQNQK DCTLTCNYGN GGCQHSCEDT DTGPMCGCHQ KYALHSDGRT
CIEKDEAAIE RSQFNATSVA DVDKRVKRRL LMETCAVNNG GCDRTCKDTA TGVRCSCPVG
FTLQPDGKTC KDINECLVNN GGCDHSCRNT VGSFECGCRK GHKLLTDERT CQDVDECSFE
RTCDHICINS PGSFQCLCDH GYTLYGTTHC GDVDECSMDN GSCGHGCVNT KGSYECVCPL
GRRLHWNRKD CVEMGKCLSR TKTSPQAQLS CSKAGGVETC FLSCPGHTLF MPDSENSYIL
SCGVPGLQGK MLQKRNGTSS GGGGPSCSDA PTTPIKQKAR FKIRDAKCHL WPHSREQTKE
TPRLPLLDNC HVTFVTLKCD SSKKKRRGRK SPSKEVSHIT AEFEVEVKME EASDTCEADC
MRKRAEQSLQ AAIRTLRRSI GRQQFYVQVS GTEYEVAQRP AKALEGQGTC ATGQMLQDSK
CGVCRPGSYF SGELGQCVPC VPGTYQDVEG QLSCTPCPSS DGLGVAGARN VSECGGQCSP
GFFSADGFKP CQACPVGMYQ PEPGRTGCFP CGGGLLTKHE GAATFQDCEA KVHCSPGHHY
NTSTHRCIRC PVGTYQPEFG QNHCITCPGN TSTDFDGSTN VTHCKNQHCG GELGDYTGYI
ESPNYPGDYP ANAECVWHIA PPPKRRILIV VPEIFLPIED ECGDVLVMRK SASPTSITTY
ETCQTYERPI AFTSRSRKLW IQFKSNEGNS GKGFQVPYVT YDEDYQQLIE DIVRDGRLYA
SENHQEILKD KKLIKALFDV LAHPQNYFKY TAQESKEMFP RSFIKLLRSK VSRFLRPYK
//
