ID H0WJV3_OTOGA Unreviewed; 637 AA.
AC H0WJV3;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 24-JAN-2024, entry version 69.
DE SubName: Full=Kallikrein B1 {ECO:0000313|Ensembl:ENSOGAP00000001800.2};
GN Name=KLKB1 {ECO:0000313|Ensembl:ENSOGAP00000001800.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000001800.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000001800.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR EMBL; AAQR03095041; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0WJV3; -.
DR STRING; 30611.ENSOGAP00000001800; -.
DR Ensembl; ENSOGAT00000002018.2; ENSOGAP00000001800.2; ENSOGAG00000002016.2.
DR eggNOG; KOG3627; Eukaryota.
DR GeneTree; ENSGT00940000161669; -.
DR HOGENOM; CLU_031604_0_0_1; -.
DR InParanoid; H0WJV3; -.
DR OMA; TAMYTPN; -.
DR TreeFam; TF343687; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0007596; P:blood coagulation; IEA:UniProtKB-KW.
DR GO; GO:0031639; P:plasminogen activation; IEA:Ensembl.
DR GO; GO:0051919; P:positive regulation of fibrinolysis; IEA:Ensembl.
DR CDD; cd01100; APPLE_Factor_XI_like; 4.
DR CDD; cd00190; Tryp_SPc; 1.
DR Gene3D; 3.50.4.10; Hepatocyte Growth Factor; 4.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 1.
DR InterPro; IPR000177; Apple.
DR InterPro; IPR003609; Pan_app.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001314; Peptidase_S1A.
DR InterPro; IPR001254; Trypsin_dom.
DR InterPro; IPR018114; TRYPSIN_HIS.
DR InterPro; IPR033116; TRYPSIN_SER.
DR PANTHER; PTHR24253:SF64; PLASMA KALLIKREIN; 1.
DR PANTHER; PTHR24253; TRANSMEMBRANE PROTEASE SERINE; 1.
DR Pfam; PF00024; PAN_1; 4.
DR Pfam; PF00089; Trypsin; 1.
DR PRINTS; PR00005; APPLEDOMAIN.
DR PRINTS; PR00722; CHYMOTRYPSIN.
DR SMART; SM00223; APPLE; 4.
DR SMART; SM00020; Tryp_SPc; 1.
DR SUPFAM; SSF57414; Hairpin loop containing domain-like; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS00495; APPLE; 1.
DR PROSITE; PS50948; PAN; 3.
DR PROSITE; PS50240; TRYPSIN_DOM; 1.
DR PROSITE; PS00134; TRYPSIN_HIS; 1.
DR PROSITE; PS00135; TRYPSIN_SER; 1.
PE 4: Predicted;
KW Blood coagulation {ECO:0000256|ARBA:ARBA00023084};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hemostasis {ECO:0000256|ARBA:ARBA00022696};
KW Hydrolase {ECO:0000256|RuleBase:RU363034};
KW Protease {ECO:0000256|RuleBase:RU363034};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Serine protease {ECO:0000256|RuleBase:RU363034};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..637
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003543616"
FT DOMAIN 111..194
FT /note="Apple"
FT /evidence="ECO:0000259|PROSITE:PS50948"
FT DOMAIN 201..283
FT /note="Apple"
FT /evidence="ECO:0000259|PROSITE:PS50948"
FT DOMAIN 291..374
FT /note="Apple"
FT /evidence="ECO:0000259|PROSITE:PS50948"
FT DOMAIN 390..625
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|PROSITE:PS50240"
SQ SEQUENCE 637 AA; 70122 MW; 26EBFB0538979FA4 CRC64;
MISFGQTAYL MALFSTVSCG CLTQLYQNTF FRGGDLTAIY TPNALHCRTV CTLHPKCLLF
SYLPASSTNN TGKRFGCFLK DSITGVLPRV HLMSAISGHS LKQCGHQISA CHRETYEGID
MRGVNFNVSK VDSVEECQKW CTNNIHCQFF TYATQTFANA EYRNNCLLKH SPSGTPTSIK
VLDNVVSGFS LKPCALSEIG CHMDLFQNLA FSDAAVARVL TPDAFVCRTI CTYHPSCLFF
TFYTSAWNAE SQRNVCFLKT SQSGTPTSTT QENTISGYSL LTCKRTLPEP CHSKIYPGVD
FGGEDLNVTF VSGASVCQET CTQMVRCQFF TYSLLPKDCR GQKCKCSLKL SPDGSPTSIT
YGTQARSGYS LRLCKAGDSS VCTTKINTRI VGGTNSSWGE WPWQVSLQVQ LAGRRHLCGG
SIIGHQWVLT AAHCFDGLPL PDIWRIYSGI LNLSDITGET PFSLIKEIII HPNYKISEGG
HDIALLKLQA PLNYTEFQKP ICLPSQGDVN TIYTNCWVTG WGFSKEKGEI QNTLQKANIP
LVTNEECQKR YRDYDITKQM LCAGHKEGGK DTCKGDSGGP LVCKHSGIWH LVGITSWGEG
CGRREQPGVY TKVAEYVDWI LEKTQGSGGD ALLTASS
//