GenomeNet

Database: UniProt
Entry: H0WJV3_OTOGA
LinkDB: H0WJV3_OTOGA
Original site: H0WJV3_OTOGA 
ID   H0WJV3_OTOGA            Unreviewed;       637 AA.
AC   H0WJV3;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   24-JAN-2024, entry version 69.
DE   SubName: Full=Kallikrein B1 {ECO:0000313|Ensembl:ENSOGAP00000001800.2};
GN   Name=KLKB1 {ECO:0000313|Ensembl:ENSOGAP00000001800.2};
OS   Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC   Galagidae; Otolemur.
OX   NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000001800.2, ECO:0000313|Proteomes:UP000005225};
RN   [1] {ECO:0000313|Proteomes:UP000005225}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA   Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA   Walker B.J., Sharpe T., Hall G.;
RT   "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL   Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSOGAP00000001800.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR   EMBL; AAQR03095041; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; H0WJV3; -.
DR   STRING; 30611.ENSOGAP00000001800; -.
DR   Ensembl; ENSOGAT00000002018.2; ENSOGAP00000001800.2; ENSOGAG00000002016.2.
DR   eggNOG; KOG3627; Eukaryota.
DR   GeneTree; ENSGT00940000161669; -.
DR   HOGENOM; CLU_031604_0_0_1; -.
DR   InParanoid; H0WJV3; -.
DR   OMA; TAMYTPN; -.
DR   TreeFam; TF343687; -.
DR   Proteomes; UP000005225; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0007596; P:blood coagulation; IEA:UniProtKB-KW.
DR   GO; GO:0031639; P:plasminogen activation; IEA:Ensembl.
DR   GO; GO:0051919; P:positive regulation of fibrinolysis; IEA:Ensembl.
DR   CDD; cd01100; APPLE_Factor_XI_like; 4.
DR   CDD; cd00190; Tryp_SPc; 1.
DR   Gene3D; 3.50.4.10; Hepatocyte Growth Factor; 4.
DR   Gene3D; 2.40.10.10; Trypsin-like serine proteases; 1.
DR   InterPro; IPR000177; Apple.
DR   InterPro; IPR003609; Pan_app.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR   InterPro; IPR001314; Peptidase_S1A.
DR   InterPro; IPR001254; Trypsin_dom.
DR   InterPro; IPR018114; TRYPSIN_HIS.
DR   InterPro; IPR033116; TRYPSIN_SER.
DR   PANTHER; PTHR24253:SF64; PLASMA KALLIKREIN; 1.
DR   PANTHER; PTHR24253; TRANSMEMBRANE PROTEASE SERINE; 1.
DR   Pfam; PF00024; PAN_1; 4.
DR   Pfam; PF00089; Trypsin; 1.
DR   PRINTS; PR00005; APPLEDOMAIN.
DR   PRINTS; PR00722; CHYMOTRYPSIN.
DR   SMART; SM00223; APPLE; 4.
DR   SMART; SM00020; Tryp_SPc; 1.
DR   SUPFAM; SSF57414; Hairpin loop containing domain-like; 1.
DR   SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR   PROSITE; PS00495; APPLE; 1.
DR   PROSITE; PS50948; PAN; 3.
DR   PROSITE; PS50240; TRYPSIN_DOM; 1.
DR   PROSITE; PS00134; TRYPSIN_HIS; 1.
DR   PROSITE; PS00135; TRYPSIN_SER; 1.
PE   4: Predicted;
KW   Blood coagulation {ECO:0000256|ARBA:ARBA00023084};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Hemostasis {ECO:0000256|ARBA:ARBA00022696};
KW   Hydrolase {ECO:0000256|RuleBase:RU363034};
KW   Protease {ECO:0000256|RuleBase:RU363034};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW   Serine protease {ECO:0000256|RuleBase:RU363034};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..637
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003543616"
FT   DOMAIN          111..194
FT                   /note="Apple"
FT                   /evidence="ECO:0000259|PROSITE:PS50948"
FT   DOMAIN          201..283
FT                   /note="Apple"
FT                   /evidence="ECO:0000259|PROSITE:PS50948"
FT   DOMAIN          291..374
FT                   /note="Apple"
FT                   /evidence="ECO:0000259|PROSITE:PS50948"
FT   DOMAIN          390..625
FT                   /note="Peptidase S1"
FT                   /evidence="ECO:0000259|PROSITE:PS50240"
SQ   SEQUENCE   637 AA;  70122 MW;  26EBFB0538979FA4 CRC64;
     MISFGQTAYL MALFSTVSCG CLTQLYQNTF FRGGDLTAIY TPNALHCRTV CTLHPKCLLF
     SYLPASSTNN TGKRFGCFLK DSITGVLPRV HLMSAISGHS LKQCGHQISA CHRETYEGID
     MRGVNFNVSK VDSVEECQKW CTNNIHCQFF TYATQTFANA EYRNNCLLKH SPSGTPTSIK
     VLDNVVSGFS LKPCALSEIG CHMDLFQNLA FSDAAVARVL TPDAFVCRTI CTYHPSCLFF
     TFYTSAWNAE SQRNVCFLKT SQSGTPTSTT QENTISGYSL LTCKRTLPEP CHSKIYPGVD
     FGGEDLNVTF VSGASVCQET CTQMVRCQFF TYSLLPKDCR GQKCKCSLKL SPDGSPTSIT
     YGTQARSGYS LRLCKAGDSS VCTTKINTRI VGGTNSSWGE WPWQVSLQVQ LAGRRHLCGG
     SIIGHQWVLT AAHCFDGLPL PDIWRIYSGI LNLSDITGET PFSLIKEIII HPNYKISEGG
     HDIALLKLQA PLNYTEFQKP ICLPSQGDVN TIYTNCWVTG WGFSKEKGEI QNTLQKANIP
     LVTNEECQKR YRDYDITKQM LCAGHKEGGK DTCKGDSGGP LVCKHSGIWH LVGITSWGEG
     CGRREQPGVY TKVAEYVDWI LEKTQGSGGD ALLTASS
//
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