ID H0WKD5_OTOGA Unreviewed; 529 AA.
AC H0WKD5;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Ectonucleoside triphosphate diphosphohydrolase 3 {ECO:0000313|Ensembl:ENSOGAP00000002023.2};
GN Name=ENTPD3 {ECO:0000313|Ensembl:ENSOGAP00000002023.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000002023.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000002023.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the GDA1/CD39 NTPase family.
CC {ECO:0000256|ARBA:ARBA00009283, ECO:0000256|RuleBase:RU003833}.
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DR EMBL; AAQR03111855; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03111856; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03111857; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03111858; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03111859; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003794534.1; XM_003794486.2.
DR AlphaFoldDB; H0WKD5; -.
DR STRING; 30611.ENSOGAP00000002023; -.
DR Ensembl; ENSOGAT00000002269.2; ENSOGAP00000002023.2; ENSOGAG00000002266.2.
DR GeneID; 100965533; -.
DR KEGG; oga:100965533; -.
DR CTD; 956; -.
DR eggNOG; KOG1386; Eukaryota.
DR GeneTree; ENSGT01100000263542; -.
DR HOGENOM; CLU_010246_2_3_1; -.
DR InParanoid; H0WKD5; -.
DR OMA; GNAISDM; -.
DR OrthoDB; 180318at2759; -.
DR TreeFam; TF332859; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0017110; F:nucleoside diphosphate phosphatase activity; IEA:Ensembl.
DR GO; GO:0017111; F:ribonucleoside triphosphate phosphatase activity; IEA:Ensembl.
DR GO; GO:0009134; P:nucleoside diphosphate catabolic process; IEA:Ensembl.
DR GO; GO:0009143; P:nucleoside triphosphate catabolic process; IEA:Ensembl.
DR Gene3D; 3.30.420.40; -; 1.
DR Gene3D; 3.30.420.150; Exopolyphosphatase. Domain 2; 1.
DR InterPro; IPR000407; GDA1_CD39_NTPase.
DR PANTHER; PTHR11782; ADENOSINE/GUANOSINE DIPHOSPHATASE; 1.
DR PANTHER; PTHR11782:SF38; ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 3; 1.
DR Pfam; PF01150; GDA1_CD39; 1.
DR PROSITE; PS01238; GDA1_CD39_NTPASE; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW Hydrolase {ECO:0000256|RuleBase:RU003833};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..43
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 486..510
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT ACT_SITE 182
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600407-1"
FT BINDING 222..226
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR600407-2"
SQ SEQUENCE 529 AA; 59084 MW; 773C1EB2A1D8DE1B CRC64;
MFAVLTRQPC EQAGLKALYR TPAIIGLVVL VVSVVVLVSI TLIQIHKQEV LPPGLKYGIV
LDAGSSRTTV YVYQWPAEKE NNTGVVSQIF KCSVKGSGIS SYGKNPQDVP KAFEECMQKV
KGQIPTHLHG STRVHLGATA GMRLLRLQNE TAANEVLASI QSYFKSQPFD FRGAQIISGQ
EEGVYGWITA NYLMGNFLEK NLWHMWVHPH GVETTGALDL GGASTQISFV AGENVELNTS
DITRVSLYGY TYALYTHSFQ CYGRNEAEKR FLAMLLQNST TKTYLSNPCY PRDYSTNFTM
GHVFDSLCTV SHRPASYNPD DIITFEGTGN PLLCREKVAS TFDFKTCHDP DTCSSGGVYQ
PKVKGPFVAF AGFYYTASAL NLSGSFSLDT FNSKTWNFCS QNWSQLPLLL PKFDEVYARS
YCFSANYIYH LFVNGYKFTE DTWSQIHFEK EVGNSSIAWS LGYMLNLTNQ IPAESPLIRL
PIQQPVFVGT LAFFTVAALL CLALFVYMCF LSRKMRHSEH VFNHAVDSD
//
