ID H0WKH9_OTOGA Unreviewed; 1442 AA.
AC H0WKH9;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=PH domain and leucine rich repeat protein phosphatase 1 {ECO:0000313|Ensembl:ENSOGAP00000002081.2};
GN Name=PHLPP1 {ECO:0000313|Ensembl:ENSOGAP00000002081.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000002081.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000002081.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAQR03056586; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03056587; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03056588; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03056589; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03056590; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03056591; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03056592; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03056593; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03056594; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03056595; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 30611.ENSOGAP00000002081; -.
DR Ensembl; ENSOGAT00000002332.2; ENSOGAP00000002081.2; ENSOGAG00000002330.2.
DR eggNOG; KOG0618; Eukaryota.
DR GeneTree; ENSGT00940000158137; -.
DR HOGENOM; CLU_003020_0_0_1; -.
DR InParanoid; H0WKH9; -.
DR OMA; GHNQICD; -.
DR TreeFam; TF315993; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0009649; P:entrainment of circadian clock; IEA:Ensembl.
DR GO; GO:0051898; P:negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; IEA:Ensembl.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0046328; P:regulation of JNK cascade; IEA:Ensembl.
DR GO; GO:1900744; P:regulation of p38MAPK cascade; IEA:Ensembl.
DR GO; GO:0002667; P:regulation of T cell anergy; IEA:Ensembl.
DR CDD; cd13322; PH_PHLPP-like; 1.
DR CDD; cd00143; PP2Cc; 1.
DR CDD; cd17240; RA_PHLPP1; 1.
DR Gene3D; 3.60.40.10; PPM-type phosphatase domain; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036457; PPM-type-like_dom_sf.
DR InterPro; IPR001932; PPM-type_phosphatase-like_dom.
DR PANTHER; PTHR48051; -; 1.
DR PANTHER; PTHR48051:SF37; PH DOMAIN AND LEUCINE-RICH REPEAT PROTEIN PHOSPHATASE 2; 1.
DR Pfam; PF13516; LRR_6; 2.
DR Pfam; PF13855; LRR_8; 2.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00481; PP2C; 1.
DR SMART; SM00364; LRR_BAC; 9.
DR SMART; SM00369; LRR_TYP; 9.
DR SMART; SM00332; PP2Cc; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF81606; PP2C-like; 1.
DR PROSITE; PS51450; LRR; 3.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS51746; PPM_2; 1.
PE 4: Predicted;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 266..366
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 905..1152
FT /note="PPM-type phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS51746"
FT REGION 1..164
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 176..197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1188..1240
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1378..1442
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 84..100
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1194..1224
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1398..1412
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1442 AA; 157518 MW; 5D1639DE52F720BE CRC64;
PSEPQDLEPQ PARSALAAVG GPPRAPPADL PLPGDDRGGW ARCASRVSPA PSDSSPGEPF
ARGPTSPPGT PRPLDGAAAG PASDTESFSL SPSAESVSDR LDPYSSGGGG GSSSSDELEA
DPAPAGAPSQ LRRLGRPSPG SPPGPQQKAP RGVDGPGGVA RDGPWGEKAA VTAALGGPMS
IPGRSGVAAE KAPPPPPPPT LYVQLHGETT RRLEADEKPL QIQNDYLFQL GFGELWRVQE
EGMDSEIGCL IRFYAGKPHS IGSSERIQLS GMYNVRKGKM QLPVNRWTRR QVILCGTCLI
VSSVKDSLTG KMHVLPLIGG KVEEVKKHQH CLAFSSSGPQ SQTYYICFDT FTEYLRWLRQ
VSKVASQRIS SVDLSCCSLE HLPANLFYSQ DLTHLNLKQN FLRQNPSLPA ARGLNELQRF
TKLKSLNLSN NHLGDFPLAV CSIPTLAELN VSCNALRAVP AAVGAMHNLQ TFLLDGNFLQ
SLPAELENMH QLSYLGLSFN EFTDIPEVLE KLTAVDKLCM SGNCMETLRL QALRKMPHIK
HVDLRLNTIR KLIADEVDFL QHVTQLDLRD NKLGDLDAMI FNNIEVLHCE RNQLVTLNIC
GYFLKALYAS SNELVQLDVY PVPNYLSYMD VSRNRLENVP EWVCESRKLE VLDISHNEIC
ELPARLFCNS SLRKLLAGHN QLARLPERLE RTSVEVLDVQ HNQILELPPN LLMKADSLRF
LNASANKLET LPPATLCEET NSILQELYLT NNSLTDKCVP LLTGHPHLKI LHMAYNRLQS
FPASKMAKLE ELEEIDISGN KLKAIPTTIM NCRRMHTVIA HSNCIEVFPE VMQLPEIKCV
DLSCNELSEV TLPENLPPKL QELDLTGNPR LVLDHKTLEL LNNIRCFKID QPSAGDTSGA
PAVWSHGYTE ASGVKNKLCV AALSVNNFCD NREALYGVFD GDRNVEVPYL LQCTMSDILA
EELQKTKNEE EYMVNTFIVM QRKLGTAGQK LGGAAVLCHI KHDPVDPGGS FTLTSANVGK
CQSVLCRNGK PLPLSRSYVM SCEEELKRIK QHKAIITEDG KVNGVTESTR ILGYTFLHPS
VVPRPHVQSV LLTPRDEFFI LGSKGLWDSL SIEEAVEAVR NVPDALAAAK KLCTLAQSYG
CHDSISAVVV QLSVTEDSFC CCELSASGTV PPPSPGIFPP SVNMVIKDRP SDGLGVPSSS
SGMASEISSE LSTSEMSSEV GSTASDEPPP GALNESSPAC PSEQRCMLHP LCLSNSFQRQ
LSSATFSSAF SDNGLDSDDE EPIEGVFTNG SRVEVEVDIH CSRAKEREKQ QHLLQVPAEA
SDEGIVISAN EDEPGLPRKA DFSAVGTIGR RRPNGSVAPQ ERSHNVIEVA ADAPLRKPGG
YFAAPAQPDP DDQFIIPPEL EEEVKEIMKH HQEQQQPQPQ LQPPPQRHYQ VDQLPDCYDT
PL
//
