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Database: UniProt
Entry: H0WL76_OTOGA
LinkDB: H0WL76_OTOGA
Original site: H0WL76_OTOGA 
ID   H0WL76_OTOGA            Unreviewed;      2152 AA.
AC   H0WL76;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   27-SEP-2017, entry version 37.
DE   RecName: Full=Voltage-dependent T-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=CACNA1I {ECO:0000313|Ensembl:ENSOGAP00000002382};
OS   Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini;
OC   Lorisiformes; Galagidae; Otolemur.
OX   NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000002382, ECO:0000313|Proteomes:UP000005225};
RN   [1] {ECO:0000313|Ensembl:ENSOGAP00000002382}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA   Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA   Walker B.J., Sharpe T., Hall G.;
RT   "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL   Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSOGAP00000002382}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. This channel gives
CC       rise to T-type calcium currents. T-type calcium channels belong to
CC       the "low-voltage activated (LVA)" group and are strongly blocked
CC       by nickel and mibefradil. A particularity of this type of channels
CC       is an opening at quite negative potentials, and a voltage-
CC       dependent inactivation. T-type channels serve pacemaking functions
CC       in both central neurons and cardiac nodal cells and support
CC       calcium signaling in secretory cells and vascular smooth muscle.
CC       They may also be involved in the modulation of firing patterns of
CC       neurons which is important for information processing as well as
CC       in cell growth processes. {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOGAP00000002382}.
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DR   EMBL; AAQR03016148; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAQR03016149; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 30611.ENSOGAP00000002382; -.
DR   Ensembl; ENSOGAT00000002662; ENSOGAP00000002382; ENSOGAG00000002655.
DR   eggNOG; KOG2302; Eukaryota.
DR   eggNOG; COG1226; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; H0WL76; -.
DR   OMA; SPSVNCT; -.
DR   OrthoDB; EOG091G02L1; -.
DR   TreeFam; TF313555; -.
DR   Proteomes; UP000005225; Unassembled WGS sequence.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0008332; F:low voltage-gated calcium channel activity; IEA:InterPro.
DR   GO; GO:0070509; P:calcium ion import; IEA:InterPro.
DR   GO; GO:0030317; P:flagellated sperm motility; IEA:InterPro.
DR   GO; GO:0019228; P:neuronal action potential; IEA:Ensembl.
DR   GO; GO:0030431; P:sleep; IEA:Ensembl.
DR   InterPro; IPR030162; CACNA1I.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR005445; VDCC_T_a1.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF258; PTHR10037:SF258; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01629; TVDCCALPHA1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005225};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   SIGNAL        1     18       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        19   2152       Voltage-dependent T-type calcium channel
FT                                subunit alpha. {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003544334.
FT   TRANSMEM     42     61       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    129    153       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    266    287       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    293    318       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    599    625       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    632    651       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    690    712       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    732    748       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    768    790       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1102   1120       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1140   1161       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1173   1199       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1237   1259       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1338   1362       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1418   1435       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1455   1474       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1553   1572       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1639   1661       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        1    329       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      568    795       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1100   1372       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1418   1671       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED     1371   1398       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2152 AA;  238040 MW;  435C19CF38E40D1F CRC64;
     WFECVSMLVI LLNCVTLGMY QPCDDMDCLS DRCKILQVFD DFIFIFFAME MVLKMVALGI
     FGKKCYLGDT WNRLDFFIVM AGMVEYSLDL QNINLSAIRT VRVLRPLKAI NRVPSMRILV
     NLLLDTLPML GNVLLLCFFV FFIFGIIGVQ LWAGLLRNRC FLEENFTIQG DVALPPYYQP
     EEDDEMPFIC SLSGDNGIMG CHEIPPLKEQ GRECCLSKDD VYDFGTGRQD LNASGLCVNW
     NRYYNVCRTG SANPHKGAIN FDNIGYAWIV IFQVITLEGW VEIMYYVMDA HSFYNFIYFI
     LLIIVGSFFM INLCLVVIAT QFSETKQREH RLMLEQRQRY LSSSTVASYA EPGDCYEEIF
     QYVCHILRKA KRRALGLYQA LQNRRQALGP GAPAPAPAKP GPHAKEPRHY NGKTKAQVAA
     GSQRGSEPAQ ALEGSLLALP AHSRTSSPPP HQLCPRHSPL DPTPHALVQP ISATLASDPA
     SCPRCQHEAG RRPSGLGSTD SGQEGSGSGG SCGGEDEADG DGAQSSEDGA SSGLEKEDEE
     EQADGPARLC GAVWRETRAK LRGIVDSKYF NRGIMMAILV NTVSMGIEHH EQASELTNVL
     EICNVVFTSM FALEMILKLA AFGLFDYLRN PYNIFDSIIV IISIWEIVGQ ADGGLSVLRT
     FRLLRVLKLV RFMPALRRQL VVLMKTMDNV ATFCMLLMLF IFIFSILGMH IFGCKFSLRT
     DTGDTVPDRK NFDSLLWAIV TVFQILTQED WNVVLYNGMA STSPWASLYF VALMTFGNYV
     LFNLLVAILV EGFQAEGDAN RSYSDEDQSS SNIEEFDKLQ EGLDISGDPK LCPVPMTPNG
     HLDPSLPLAG HLGHTGAVAP APRLSLQPDP VLVALGSRKS SVMSLGRMSY DQRSLSSSRS
     SYYGPWGRSG AWASRRSSWN SLKHKPPSAE HESLLSAERG SSTRACEAVG DEAPPRVVPL
     HAPHTHHAHH AHHGHHLAHR HRHHRRTLSL DTRDSVDLAE LVPTMGAHPR AAWRAAGPAP
     GHEDCNGRMP SIAKDVFTKM DDRRDRGDDE EEIDYTLCFR VRKMIDVYKP DWCEVRRNWS
     VYLFSPENRF RVLCQTIIAH KLFDYVVLAF IFLNCITIAL ERPQIEAGST ERIFLTVSNY
     IFTAIFVGEM TLKVVSLGLY FGEQAYLRSS WNVLDGFLVF VSIIDIVVSV ASAGGAKILG
     VLRVLRLLRT LRPLRVISRA PGLKLVVETL ISSLKPIGNI VLICCAFFII FGILGVQLFK
     GKFYHCLGVD TRNITNRSDC MAANYRWVHH KYNFDNLGQA LMSLFVLASK DGWVNIMYNG
     LDAVAVDQQP VTNHNPWMLL YFISFLLIVS FFVLNMFVGV VVENFHKCRQ HQEAEEARRR
     EEKRLRRLEK KRRKAQRLPY YATYCPTRLL IHSMCTSHYL DIFITFIICL NVVTMSLEHY
     NQPTSLETAL KYCNYMFTTV FVLEAVLKLV AFGLRRFFKD RWNQLDLAIV LLSVMGITLE
     EIEINAALPI NPTIIRIMRV LRIARVLKLL KMATGMRALL DTVVQALPQV GNLGLLFMLL
     FFIYAALGVE LFGKLVCNEE NPCEGMSRHA TFENFGMAFL TLFQVSTGDN WNGIMKDTLR
     DCTHDERSCL SSLQFVSPLY FVSFVLTAQF VLINVVVAVL MKHLDDSNKE AQEDAEMDAE
     IELEMAHSLG PSPRPPTSSP GVPGHGPGGV GSGCDAEGRL CRRCYSPAQE TLWLDSVSLI
     IKDSLEGELT IIDNLSGSVF HHYASPAGHG KCLHDQQEVQ LAETEAFSLN SDRSSSILLG
     DDLSLEDPTI CPSGHKDSKG ELDLPEPMCV GDLGECFFPL STTAISSGPE NFLCEMEAIP
     FNPVRSWLKH ESSQALPSRP FSPDASSPLL PMPPEFFHPA VSASQKGQEK GTGAESLPKI
     SLQGSWASLR SPSVNCTLLR QATGSDTSLD ASPSSSAGSL QTTLEDSLTL SDSPRRTLGP
     PAPAMGPRAG LSPAARRRLS LRGRGLFSLR GLRAHQRSHS SGGSTSPGCT HHDSMDPSDE
     EGRGGASGGG AGSEHSETLS SLSLTSLFCP PPPPPPPGLT PSRKFSSTSS LATGPGRPRA
     PTAQPRGLAR SPSWAADRSK DPPGSGLGPS GPEPQPPPGD LELGDAASKR KR
//
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