ID H0WLM4_OTOGA Unreviewed; 532 AA.
AC H0WLM4;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Solute carrier family 29 member 4 {ECO:0000313|Ensembl:ENSOGAP00000002569.2};
GN Name=SLC29A4 {ECO:0000313|Ensembl:ENSOGAP00000002569.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000002569.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000002569.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Apical cell membrane
CC {ECO:0000256|ARBA:ARBA00004424}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004424}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
CC {ECO:0000256|ARBA:ARBA00007965}.
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DR EMBL; AAQR03119707; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003795489.1; XM_003795441.2.
DR AlphaFoldDB; H0WLM4; -.
DR STRING; 30611.ENSOGAP00000002569; -.
DR Ensembl; ENSOGAT00000002870.2; ENSOGAP00000002569.2; ENSOGAG00000002865.2.
DR GeneID; 100961974; -.
DR KEGG; oga:100961974; -.
DR CTD; 222962; -.
DR eggNOG; KOG1479; Eukaryota.
DR GeneTree; ENSGT00950000182898; -.
DR HOGENOM; CLU_021611_4_0_1; -.
DR InParanoid; H0WLM4; -.
DR OMA; ARGMNEF; -.
DR OrthoDB; 2939652at2759; -.
DR TreeFam; TF313950; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:Ensembl.
DR GO; GO:0098793; C:presynapse; IEA:GOC.
DR GO; GO:0015562; F:efflux transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0008504; F:monoamine transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0005326; F:neurotransmitter transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0005337; F:nucleoside transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0005342; F:organic acid transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0015101; F:organic cation transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0019534; F:toxin transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0032238; P:adenosine transport; IEA:Ensembl.
DR GO; GO:0090494; P:dopamine uptake; IEA:Ensembl.
DR GO; GO:0051625; P:epinephrine uptake; IEA:Ensembl.
DR GO; GO:0140115; P:export across plasma membrane; IEA:Ensembl.
DR GO; GO:0051615; P:histamine uptake; IEA:Ensembl.
DR GO; GO:0051620; P:norepinephrine uptake; IEA:Ensembl.
DR GO; GO:0051610; P:serotonin uptake; IEA:Ensembl.
DR InterPro; IPR002259; Eqnu_transpt.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR10332; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER; 1.
DR PANTHER; PTHR10332:SF89; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 4; 1.
DR Pfam; PF01733; Nucleoside_tran; 1.
DR PIRSF; PIRSF016379; ENT; 2.
DR PRINTS; PR01130; DERENTRNSPRT.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 70..90
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 110..128
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 140..161
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 233..253
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 354..376
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 388..407
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 419..441
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 453..472
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 484..508
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 532 AA; 58248 MW; 0F99CD42AA82A28D CRC64;
MGSIGSQRLK EPSVVETPDR TVAMSFSFDS HQLEAAAAEA TLGLDVRARG VPAFMDSVEE
EPVPDDRYHA IYFAMLLAGV GFLLPYNSFI TDVDHLHHKY PGTSIVFDMS LTYILVALVA
VLLNNVLVER LDLHTRITAG YLLALGPLLF ISICDVWLQL FSRDQAYAIN LAAVGTVAFG
CTVQQSSFYG YTGMLPKRYT QGVMTGESTA GVMISLSRIL TKLLLPDERA STLIFFLVSV
GLELLCFLLH LLVRRSRFVL YYAARPRDSR RGCRAGPGRS SGYRVHHDVA AEDIHFEHQA
PALATSGSPK DSPVHEVTGS GGAYMRFDVP QPRVQQSWPT FRALLLHRYV VARVIWADML
SIAVTYFITL CLFPGLESEI RHCMLGEWLP ILIMAVFNLS DFVGKILAAL PVAWRDTHLL
ACSCLRVVFI PLFILCVYPS GMPALRHPAW PCVFSLLMGV SNGYFGSVPM ILAASKVGPK
QRELAGNTMT VSYMSGLTLG SAVAYFTYSL TRDAHGSCLL TSAANGSASA GL
//
