ID H0WMJ5_OTOGA Unreviewed; 612 AA.
AC H0WMJ5;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=E3 ubiquitin-protein ligase {ECO:0000256|RuleBase:RU369081};
DE EC=2.3.2.27 {ECO:0000256|RuleBase:RU369081};
DE AltName: Full=RING-type E3 ubiquitin transferase {ECO:0000256|RuleBase:RU369081};
GN Name=RNF157 {ECO:0000313|Ensembl:ENSOGAP00000002965.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000002965.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000002965.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: E3 ubiquitin ligase. {ECO:0000256|RuleBase:RU369081}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900,
CC ECO:0000256|RuleBase:RU369081};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU369081}.
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DR EMBL; AAQR03041406; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03041407; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03041408; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0WMJ5; -.
DR STRING; 30611.ENSOGAP00000002965; -.
DR Ensembl; ENSOGAT00000003325.2; ENSOGAP00000002965.2; ENSOGAG00000003319.2.
DR eggNOG; KOG4265; Eukaryota.
DR GeneTree; ENSGT00390000009925; -.
DR HOGENOM; CLU_016631_2_0_1; -.
DR InParanoid; H0WMJ5; -.
DR OMA; EDSCPVH; -.
DR TreeFam; TF314969; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniRule.
DR CDD; cd16817; mRING-HC-C3HC5_RNF157; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR045194; MGRN1/RNF157-like.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR22996:SF1; E3 UBIQUITIN LIGASE RNF157; 1.
DR PANTHER; PTHR22996; MAHOGUNIN; 1.
DR Pfam; PF13920; zf-C3HC4_3; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|RuleBase:RU369081};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU369081};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Transferase {ECO:0000256|RuleBase:RU369081};
KW Ubl conjugation pathway {ECO:0000256|RuleBase:RU369081};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU369081};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 208..247
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 269..292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 365..536
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 586..612
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 270..292
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 373..387
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 388..471
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 612 AA; 66587 MW; 660723AB2A825D99 CRC64;
FPYAAPPPQE PVKTLRSLIN IRKDTLRLVK CAEEVKSPGE EASKAKVYYN VEFTFDTDAR
VAITIYYQAT EEFQNGIASY IPKDNSLQSE TVHYKRGVCQ QFCLPSHTVD PSEWAEEELV
FDLDREVYPL VVHAVVDEGD EYFGHCHVLL GTFEKHTDGT FCVKPLKQKQ VVDGVSYLLQ
EIYGIENKYN TQDSKVAEDE VSDNSAECVV CLSDVRDTLI LPCRHLCLCN TCADTLRYQA
NNCPICRLPF RALLQIRAMR KKLGPLSPPN FNPIISSQTS DSEEHSSSEN IPPGYEVVSL
LEALNGPLTP SPAVPPLHVL GDGHLSGMLP SYGSDGHLPP ARTLSPLDRL SDCSSQGLKL
KKSLSKSISQ NSSVVHEEED ERSCSESETQ LSQRPSAQHL TEECGVTPES ENLTLSSSGA
IDQSSCTGTP LSSTISSPEG PASSSLAQSV MSMASSQIST DTVSSMSGSY IAPGTEEEGE
ALPSSRAASR DPSEEGEGLP AESPESNFAG LPAGEQDAEG NDVMEEEDES PTQEDGQRTC
AFLGMECDNN NDFDIASVNA LDNTLCSEVC LPGTWHADDN IVSRRNTPRR RLSSSSLEDS
ENRPCVWGPL AV
//
