ID H0WMK5_OTOGA Unreviewed; 1515 AA.
AC H0WMK5;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Crystallin beta-gamma domain containing 2 {ECO:0000313|Ensembl:ENSOGAP00000002978.2};
GN Name=CRYBG2 {ECO:0000313|Ensembl:ENSOGAP00000002978.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000002978.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000002978.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the beta/gamma-crystallin family.
CC {ECO:0000256|ARBA:ARBA00009646}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAQR03155694; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03155695; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03155696; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03155697; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03155698; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03155699; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03155700; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 30611.ENSOGAP00000002978; -.
DR Ensembl; ENSOGAT00000003339.2; ENSOGAP00000002978.2; ENSOGAG00000003332.2.
DR eggNOG; ENOG502R2J7; Eukaryota.
DR GeneTree; ENSGT00940000157740; -.
DR HOGENOM; CLU_002147_0_1_1; -.
DR InParanoid; H0WMK5; -.
DR OMA; CVWYYED; -.
DR OrthoDB; 5354696at2759; -.
DR TreeFam; TF331078; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR Gene3D; 2.80.10.50; -; 1.
DR Gene3D; 2.60.20.10; Crystallins; 6.
DR InterPro; IPR001064; Beta/gamma_crystallin.
DR InterPro; IPR011024; G_crystallin-like.
DR InterPro; IPR035992; Ricin_B-like_lectins.
DR PANTHER; PTHR11818; BETA/GAMMA CRYSTALLIN; 1.
DR PANTHER; PTHR11818:SF42; RICIN B-TYPE LECTIN DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00030; Crystall; 6.
DR PRINTS; PR01367; BGCRYSTALLIN.
DR SMART; SM00247; XTALbg; 6.
DR SUPFAM; SSF49695; gamma-Crystallin-like; 3.
DR SUPFAM; SSF50370; Ricin B-like lectins; 1.
DR PROSITE; PS50915; CRYSTALLIN_BETA_GAMMA; 7.
DR PROSITE; PS50231; RICIN_B_LECTIN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 881..924
FT /note="Beta/gamma crystallin 'Greek key'"
FT /evidence="ECO:0000259|PROSITE:PS50915"
FT DOMAIN 971..1010
FT /note="Beta/gamma crystallin 'Greek key'"
FT /evidence="ECO:0000259|PROSITE:PS50915"
FT DOMAIN 1022..1067
FT /note="Beta/gamma crystallin 'Greek key'"
FT /evidence="ECO:0000259|PROSITE:PS50915"
FT DOMAIN 1068..1110
FT /note="Beta/gamma crystallin 'Greek key'"
FT /evidence="ECO:0000259|PROSITE:PS50915"
FT DOMAIN 1157..1199
FT /note="Beta/gamma crystallin 'Greek key'"
FT /evidence="ECO:0000259|PROSITE:PS50915"
FT DOMAIN 1248..1291
FT /note="Beta/gamma crystallin 'Greek key'"
FT /evidence="ECO:0000259|PROSITE:PS50915"
FT DOMAIN 1338..1379
FT /note="Beta/gamma crystallin 'Greek key'"
FT /evidence="ECO:0000259|PROSITE:PS50915"
FT REGION 65..208
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 241..282
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 326..351
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 421..448
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 461..486
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 501..557
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 662..729
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 65..91
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 97..111
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 182..196
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 332..351
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 428..448
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 520..557
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 681..698
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1515 AA; 164331 MW; 81F4CA5573561EC3 CRC64;
MEEASGPPAR AEARVVSAIL TWRQRPPAQE EIRHHFHKVS LVSGAPREEM LERSHRQDEV
NGFATWQEET GNCQGSRDGA GSKNFQSHGP VFSKKYTPPP KEKRPVGRLK EAVDQGDGSP
QPPRTEPPGL GSMAKTEFLV PLPGPREPSP HPGAGLSSGS SRSREERRVT RTVRTTMVVG
GHVDQHVNSS VTVGPSISGD ALPRGRNVAR TVRAVVVSPR PEGSPSRSQA LELLSSLMPA
EHKPPASRLP RPIAAGSRSQ GLGSTGGAAL RQPPETKTVE LKDSSALAPA GIPAGGHLPQ
NQDVPIAHPA QDQNRVLDAR AYEYPKVQEA SSPRQLPLQT SQDQAPVSSS PRLQIHDPCL
GSAHLPEQPV VPTHPRAQLT PHILPPVKRE GLTLMDSPSA TVLPMVKNKD MKVPGQPLAL
SSKEAVSGPE GLSASTSPRN KFFQDSKNVP VISPTQIEVV QGPDAPAAPS PSTKVVQGPE
SSPDIQKEVV QGIAGSLAPS LTKKETVQGP AAPVSLTPKQ GKVAQGSEGS PSLSPPQKGV
VQGSEASAAA PSSSQKVVVQ DPVVLPAPPS SVDKVSPSPG GTLAIEAEAS REFQLIPDST
EGKTCPEPSR EEDEMALAAD LEIFLDTLRS MEPPEILRTH RLPRAPRSSY LAMYATLPPI
EEDQPGPWVL GPSPQEVPAL EEKQEEEEEE EEEPENPYLS DDEKLQRKQE KAGSGPSWDL
RPARSTQASC SPLEMMKKHV AGAKGPQPEL GLELQACGKP TSRLGGSLLF GSLMPATKEA
PTLEPLGTKL SALPPHRAPG LRKVPGQLPL LCSENPERPA CSQPQEGWSP ALKTQGKLNT
RPGKVILFLE PGCQGNSREI WEDIADASGW APIASIRVVR GCWVLYEKPQ FQGQKMVLPE
GDVDLRAPGP TWTTHGFGSL RRVVRDYSIP EISLFSEEGL QGEQVKLVEA LKDLLSLEKP
LKVASATVSA GLWLLYPKPF FEGTPYILEP GEYPTSEAWC ASVGSLKPMR LGCPSVEKPG
EPKAVVYEAP GFQGCSWEVS RDIYNIQQPE DPQSPHLTSV GSLKVLGGCW VGYEKEGFRG
HQYLLEEGEY PDWSHWGGYD ELLTSLRVIR TDFGDPAVVL FEAMDFEGHG VEVSEALPDV
ELVRHGPCTQ AIHVLSGVWV AYQEVGFSGE QYVLEKGVYR NCDDWGAGNS ALASLQPVLQ
VGEHDLHFVS KIQLFSGPDF LGERISFEDD QASLPASFQP QSCRVHGGSW ILFDEKDFKG
DQHILSEGEF PTLTAMGCLA STVLGSLRKV PLYFSEPSIF LFGLQCFEGK EIELSGEVRS
LQAEGFNNHV LSVQIKGGVW VLCEHSDFRG RQWLVGSCEI TNWLTYSGTQ RIGSLYPIKQ
RRVYFRLWNA ALGGFLAVPD HVEDMKAGRV VVSNPRAGGS CIWYYEDGLL KNQVAPTMSL
QVIGPPSPGS KVVLWAESRL PRQTWSINES GHICSQMFEG QILDVKGGRG YDRDHVVLWE
LAKERVSQNW TMHVL
//
