ID H0WMQ0_OTOGA Unreviewed; 597 AA.
AC H0WMQ0;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Cell division cycle 23 {ECO:0000313|Ensembl:ENSOGAP00000003032.2};
GN Name=CDC23 {ECO:0000313|Ensembl:ENSOGAP00000003032.2};
OS Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lorisiformes;
OC Galagidae; Otolemur.
OX NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000003032.2, ECO:0000313|Proteomes:UP000005225};
RN [1] {ECO:0000313|Proteomes:UP000005225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
RA Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
RA Walker B.J., Sharpe T., Hall G.;
RT "Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSOGAP00000003032.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAQR03009411; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03009412; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03009413; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03009414; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03009415; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03009416; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03009417; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03009418; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03009419; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAQR03009420; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003782209.1; XM_003782161.2.
DR AlphaFoldDB; H0WMQ0; -.
DR STRING; 30611.ENSOGAP00000003032; -.
DR Ensembl; ENSOGAT00000003401.2; ENSOGAP00000003032.2; ENSOGAG00000003398.2.
DR GeneID; 100963342; -.
DR KEGG; oga:100963342; -.
DR CTD; 8697; -.
DR eggNOG; KOG1155; Eukaryota.
DR GeneTree; ENSGT00950000182950; -.
DR HOGENOM; CLU_018320_3_0_1; -.
DR InParanoid; H0WMQ0; -.
DR OMA; PQYLSAW; -.
DR OrthoDB; 3131281at2759; -.
DR TreeFam; TF101055; -.
DR Proteomes; UP000005225; Unassembled WGS sequence.
DR GO; GO:0005680; C:anaphase-promoting complex; IEA:Ensembl.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007080; P:mitotic metaphase chromosome alignment; IEA:Ensembl.
DR GO; GO:0070979; P:protein K11-linked ubiquitination; IEA:Ensembl.
DR GO; GO:0030071; P:regulation of mitotic metaphase/anaphase transition; IEA:Ensembl.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR InterPro; IPR007192; APC8.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR12558; CELL DIVISION CYCLE 16,23,27; 1.
DR PANTHER; PTHR12558:SF10; CELL DIVISION CYCLE PROTEIN 23 HOMOLOG; 1.
DR Pfam; PF04049; ANAPC8; 1.
DR Pfam; PF13414; TPR_11; 1.
DR Pfam; PF13181; TPR_8; 1.
DR SMART; SM00028; TPR; 7.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS50005; TPR; 2.
PE 4: Predicted;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Reference proteome {ECO:0000313|Proteomes:UP000005225};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT DOMAIN 32..270
FT /note="Cdc23"
FT /evidence="ECO:0000259|Pfam:PF04049"
FT REPEAT 331..364
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 365..398
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
SQ SEQUENCE 597 AA; 68790 MW; C6A432903599A0E7 CRC64;
MAASTSVVPA AVTAPVVPVL STNGDFSDLR EIKKQLLLIA GLTRERGLLH SSKWSAELAF
SLPALPLAEL QPPPPVTEED AQDMDAYTLA KAYFDVKEYD RAAHFLHGCN SKKAYFLYMY
SRYLSGEKKK DDETVDSLGP LEKGQVKNEA LRELRVELSK KHQARELDGF GLYLYGVVLR
KLDLVKEAID VFVEATHVLP LHWGAWLELC NLITDKEMLK FLSLPDTWMK EFFLAHIYTE
LQLIEEALQK YQNLIDVGFS KSSYIVSQIA VAYHNIRDID KALSIFNELR KQDPYRIENM
DTFSNLLYVR SMKSELSYLA HNLCEIDKYR VETCCVIGNY YSLRSQHEKA ALYFQRALKL
NPRYLGAWTL MGHEYMEMKN TSAAIQAYRH AIEVNKRDYR AWYGLGQTYE ILKMPFYCLY
YYRRAHQLRP NDSRMLVALG ECYEKLNQLV EAKKCYWRAY AVGDVEKMAL VKLAKLHEQL
TESEQAAQCY IKYIQDIYSC GEIVEHLEES TAFRYLAQYY FKCKLWDEAS TCAQKCCAFN
DTREEGKALL RQILQLRNQG ETPSTEMPAP FFLPASLSAN NTPTRRVSPL NLSSVTP
//
